دورية أكاديمية
Targeted Quantitative Screening of Chromosome 18 Encoded Proteome in Plasma Samples of Astronaut Candidates.
| العنوان: | Targeted Quantitative Screening of Chromosome 18 Encoded Proteome in Plasma Samples of Astronaut Candidates. |
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| المؤلفون: | Kopylov AT; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Ilgisonis EV; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Moysa AA; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Tikhonova OV; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Zavialova MG; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Novikova SE; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Lisitsa AV; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Ponomarenko EA; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Moshkovskii SA; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Markin AA; Institute of Medico-Biological Problems, Russian Academy of Sciences , 123007, Moscow, Russia., Grigoriev AI; Institute of Medico-Biological Problems, Russian Academy of Sciences , 123007, Moscow, Russia., Zgoda VG; Institute of Biomedical Chemistry , 119121, Moscow, Russia., Archakov AI; Institute of Biomedical Chemistry , 119121, Moscow, Russia. |
| المصدر: | Journal of proteome research [J Proteome Res] 2016 Nov 04; Vol. 15 (11), pp. 4039-4046. Date of Electronic Publication: 2016 Aug 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society, c2002- |
| مواضيع طبية MeSH: | Astronauts* , Chromosomes, Human, Pair 18*, Plasma/*chemistry , Proteome/*analysis, Adenosine Triphosphatases/analysis ; Adult ; Healthy Volunteers ; Humans ; Middle Aged ; Prealbumin/analysis ; Young Adult |
| مستخلص: | This work was aimed at estimating the concentrations of proteins encoded by human chromosome 18 (Chr 18) in plasma samples of 54 healthy male volunteers (aged 20-47). These young persons have been certified by the medical evaluation board as healthy subjects ready for space flight training. Over 260 stable isotope-labeled peptide standards (SIS) were synthesized to perform the measurements of proteins encoded by Chr 18. Selected reaction monitoring (SRM) with SIS allowed an estimate of the levels of 84 of 276 proteins encoded by Chr 18. These proteins were quantified in whole and depleted plasma samples. Concentration of the proteins detected varied from 10 -6 M (transthyretin, P02766) to 10 -11 M (P4-ATPase, O43861). A minor part of the proteins (mostly representing intracellular proteins) was characterized by extremely high inter individual variations. The results provide a background for studies of a potential biomarker in plasma among proteins encoded by Chr 18. The SRM raw data are available in ProteomeXchange repository (PXD004374). |
| فهرسة مساهمة: | Keywords: C-HPP; human chromosome 18 (Chr 18); plasma proteome; selected reaction monitoring (SRM); targeted proteomics |
| المشرفين على المادة: | 0 (Prealbumin) 0 (Proteome) EC 3.6.1.- (Adenosine Triphosphatases) |
| تواريخ الأحداث: | Date Created: 20160727 Date Completed: 20171005 Latest Revision: 20180403 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/acs.jproteome.6b00384 |
| PMID: | 27457493 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1535-3907 |
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| DOI: | 10.1021/acs.jproteome.6b00384 |