دورية أكاديمية
Gestational length assignment based on last menstrual period, first trimester crown-rump length, ovulation, and implantation timing.
| العنوان: | Gestational length assignment based on last menstrual period, first trimester crown-rump length, ovulation, and implantation timing. |
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| المؤلفون: | Mahendru AA; Fetal Medicine Department, Nottingham University Hospitals NHS Trust, Nottingham, UK.; Department of Fetal Medicine, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK., Wilhelm-Benartzi CS; ICTU-Cancer Clinical Trials Unit, Department of Surgery and Cancer, Imperial College London, London, UK., Wilkinson IB; Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Box 98, Cambridge, CB20QQ, UK., McEniery CM; Division of Experimental Medicine and Immunotherapeutics, Addenbrooke's Hospital, University of Cambridge, Box 98, Cambridge, CB20QQ, UK., Johnson S; SPD Development Company Ltd., Bedford, UK., Lees C; Department of Fetal Medicine, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK. christoph.lees@imperial.nhs.uk.; Department of Surgery and Cancer, Institute of Developmental and Reproductive Biology, Imperial College London, London, W12 0HS, UK. christoph.lees@imperial.nhs.uk.; Department of Development and Regeneration, University Hospitals Leuven, KU Leuven, Campus Gasthuisberg, 3000, Leuven, Belgium. christoph.lees@imperial.nhs.uk. |
| المصدر: | Archives of gynecology and obstetrics [Arch Gynecol Obstet] 2016 Oct; Vol. 294 (4), pp. 867-76. Date of Electronic Publication: 2016 Jul 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8710213 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0711 (Electronic) Linking ISSN: 09320067 NLM ISO Abbreviation: Arch Gynecol Obstet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: München : Springer International, c1987- |
| مواضيع طبية MeSH: | Gestational Age*, Embryo Implantation/*physiology , Ovulation/*physiology , Ultrasonography, Prenatal/*methods, Adult ; Crown-Rump Length ; Female ; Humans ; Menstruation ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies |
| مستخلص: | Purpose: Understanding the natural length of human pregnancy is central to clinical care. However, variability in the reference methods to assign gestational age (GA) confound our understanding of pregnancy length. Assignation from ultrasound measurement of fetal crown-rump length (CRL) has superseded that based on last menstrual period (LMP). Our aim was to estimate gestational length based on LMP, ultrasound CRL, and implantation that were known, compared to pregnancy duration assigned by day of ovulation. Methods: Prospective study in 143 women trying to conceive. In 71 ongoing pregnancies, gestational length was estimated from LMP, CRL at 10-14 weeks, ovulation, and implantation day. For each method of GA assignment, the distribution in observed gestational length was derived and both agreement and correlation between the methods determined. Results: Median ovulation and implantation days were 16 and 27, respectively. The gestational length based on LMP, CRL, implantation, and ovulation was similar: 279, 278, 276.5 and 276.5 days, respectively. The distributions for observed gestational length were widest where GA was assigned from CRL and LMP and narrowest when assigned from implantation and ovulation day. The strongest correlation for gestational length assessment was between ovulation and implantation (r = 0.98) and weakest between CRL and LMP (r = 0.88). Conclusions: The most accurate method of predicting gestational length is ovulation day, and this agrees closely with implantation day. Prediction of gestational length from CRL and known LMP are both inferior to ovulation and implantation day. This information could have important implications on the routine assignment of gestational age. Competing Interests: CCL has research collaborations with Samsung Medison, Swiss Precision Diagnostics GmbH, Bedford, and Toshiba (UK), and receives occasional honoraria and travel grants which support research projects within the department. SJ is an employee of SPD Development Company Ltd. Ethical approval The study received ethical approval from the local Research Ethics Committee, and written consent was obtained at the time of recruitment. Sources of funding support AAM is supported by Cambridge Fetal Care and FSF funding from the University of Cambridge. IBW and CMM are both British Heart Foundation Fellows, and are supported by the Cambridge Biomedical Research Centre (NIHR). CWB is supported by Cancer Research UK program A6689. Role of Sponsor Cambridge University Hospital NHS Trust acted as a sponsor for this study. SJ is an employee of SPD Development Company Ltd. CCL is supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. |
| References: | Ultrasound Obstet Gynecol. 2012 Dec;40(6):630-5. (PMID: 22858888) Paediatr Perinat Epidemiol. 2007 Sep;21 Suppl 2:86-96. (PMID: 17803622) Ultrasound Obstet Gynecol. 2008 Apr;31(4):388-96. (PMID: 18348183) Ultrasound Obstet Gynecol. 2014 Jul;44(1):31-7. (PMID: 24448754) Br J Obstet Gynaecol. 1975 Sep;82(9):702-10. (PMID: 1182090) Hum Reprod. 1992 May;7(5):701-10. (PMID: 1639991) Paediatr Perinat Epidemiol. 2000 Jul;14(3):263-7. (PMID: 10949219) Hum Reprod. 2013 Oct;28(10):2848-55. (PMID: 23922246) Obstet Gynecol. 2009 Feb;113(2 Pt 1):451-61. (PMID: 19155920) Hum Reprod. 2000 Dec;15(12 ):2478-82. (PMID: 11098014) Int J Gynaecol Obstet. 2013 Dec;123(3):189-95. (PMID: 24079475) Acta Obstet Gynecol Scand. 1990;69(3):197-207. (PMID: 2220340) BMJ. 2000 Nov 18;321(7271):1259-62. (PMID: 11082086) Geburtshilfe Frauenheilkd. 2014 Jul;74(7):661-669. (PMID: 25100881) Am J Obstet Gynecol. 2004 Sep;191(3):975-8. (PMID: 15467575) Epidemiology. 1995 Sep;6(5):547-50. (PMID: 8562634) Br J Obstet Gynaecol. 1991 Jan;98(1):108-9. (PMID: 1998620) Lancet. 2011 May 28;377(9780):1812-4. (PMID: 21621710) Ultrasound Obstet Gynecol. 2010 Jun;35(6):650-5. (PMID: 20512816) JAMA. 2010 Feb 10;303(6):527-34. (PMID: 20145229) Eur J Obstet Gynecol Reprod Biol. 1989 Mar;30(3):253-6. (PMID: 2653891) Contraception. 2004 Oct;70(4):289-92. (PMID: 15451332) Biometrics. 1982 Jun;38(2):397-406. (PMID: 7115870) Br J Obstet Gynaecol. 1984 Jul;91(7):685-9. (PMID: 6743610) N Engl J Med. 1995 Dec 7;333(23):1517-21. (PMID: 7477165) Curr Med Res Opin. 2011 Feb;27(2):393-401. (PMID: 21175374) Fertil Steril. 1982 Jun;37(6):773-8. (PMID: 7115557) N Engl J Med. 1999 Jun 10;340(23):1796-9. (PMID: 10362823) Clin Exp Obstet Gynecol. 1994;21(2):108-18. (PMID: 8070114) Ultrasound Obstet Gynecol. 2012 Aug;40(2):135-9. (PMID: 22262465) Radiology. 1992 Feb;182(2):501-5. (PMID: 1732970) Obstet Gynecol. 1996 Jan;87(1):13-7. (PMID: 8532248) Curr Med Res Opin. 2009 Mar;25(3):741-8. (PMID: 19196217) |
| معلومات مُعتمدة: | 15954 United Kingdom CRUK_ Cancer Research UK; FS/12/8/29377 United Kingdom BHF_ British Heart Foundation |
| فهرسة مساهمة: | Keywords: CRL; Estimated date of delivery; Pregnancy dating; Ultrasound |
| تواريخ الأحداث: | Date Created: 20160730 Date Completed: 20170913 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC5018029 |
| DOI: | 10.1007/s00404-016-4153-3 |
| PMID: | 27469987 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0711 |
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| DOI: | 10.1007/s00404-016-4153-3 |