دورية أكاديمية
Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice.
| العنوان: | Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice. |
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| المؤلفون: | Siqueira CM; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Federal Institute of Rio de Janeiro, Brazil., Motta PD; Paulista University, São Paulo, Brazil., Cardoso TN; Paulista University, São Paulo, Brazil., de Paula Coelho C; Paulista University, São Paulo, Brazil; University of Santo Amaro, São Paulo, Brazil., Popi AF; Federal University of São Paulo, São Paulo, Brazil., Couceiro JN; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Bonamin LV; Paulista University, São Paulo, Brazil; University of Santo Amaro, São Paulo, Brazil., Holandino C; Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: cholandino@gmail.com. |
| المصدر: | Homeopathy : the journal of the Faculty of Homeopathy [Homeopathy] 2016 Aug; Vol. 105 (3), pp. 257-264. Date of Electronic Publication: 2016 May 04. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 101140517 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4245 (Electronic) Linking ISSN: 14754916 NLM ISO Abbreviation: Homeopathy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart, Germany : Thieme Original Publication: Edinburgh : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Behavior, Animal* , Influenza A Virus, H3N2 Subtype*, Inflammation/*therapy , Orthomyxoviridae Infections/*therapy , Thymic Factor, Circulating/*chemistry, Animals ; B-Lymphocytes/immunology ; Hemagglutinin Glycoproteins, Influenza Virus/immunology ; Homeopathy ; Male ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/immunology ; Random Allocation ; T-Lymphocyte Subsets/immunology |
| مستخلص: | Background: Influenza affects thousands of people worldwide every year, motivating the development of new therapies. In this work, the effects of two homeopathic preparations (influenza biotherapies and thymulin) were chosen following two different rationales: isotherapy and endo-isotherapy models. The homeopathic effects were evaluated individually considering the inflammatory and behavioral responses against influenza virus antigen were studied in BALB/c mice. Methods: Male adult mice were treated orally and blindly for 21 days with highly diluted influenza virus or with thymulin, and were divided in two sets of experiments. The first series of experiments aimed to describe their behavior, using an open field (OF) device. In the second series, mice were challenged subcutaneously with influenza hemagglutinin antigen (7 μg/200 μl) at day 21. At day 42, behavior and inflammation response were evaluated. Results: No behavioral changes were seen in OF tests at any time point after treatments. Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge, varying according to treatment. Conclusion: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations. (Copyright © 2016 The Faculty of Homeopathy. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Behavior; Homeopathy; Immunology; Influenza hemagglutinin antigen; Influenza virus; Thymulin |
| المشرفين على المادة: | 0 (Hemagglutinin Glycoproteins, Influenza Virus) 9H198D04WL (Thymic Factor, Circulating) |
| تواريخ الأحداث: | Date Created: 20160731 Date Completed: 20170417 Latest Revision: 20180305 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.homp.2016.04.002 |
| PMID: | 27473547 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-4245 |
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| DOI: | 10.1016/j.homp.2016.04.002 |