دورية أكاديمية
Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population.
| العنوان: | Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population. |
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| المؤلفون: | Santos-Cortez RL; Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA santosco@bcm.edu., Reyes-Quintos MR; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Tantoco ML; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Abbe I; Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Llanes EG; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Ajami NJ; Alkek Center for Metagenomics and Microbiome Research (CMMR), Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Hutchinson DS; Alkek Center for Metagenomics and Microbiome Research (CMMR), Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Petrosino JF; Alkek Center for Metagenomics and Microbiome Research (CMMR), Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA., Padilla CD; Institute of Human Genetics, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Pediatrics, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines.; Philippine Genome Center, University of the Philippines Diliman, Quezon City, Philippines., Villarta RL Jr; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Gloria-Cruz TL; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Chan AL; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Cutiongco-de la Paz EM; Institute of Human Genetics, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Pediatrics, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines.; Philippine Genome Center, University of the Philippines Diliman, Quezon City, Philippines., Chiong CM; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines., Leal SM; Center for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA., Abes GT; Philippine National Ear Institute, University of the Philippines Manila-National Institutes of Health, Manila, Philippines.; Department of Otorhinolaryngology, University of the Philippines College of Medicine-Philippine General Hospital, Manila, Philippines. |
| المصدر: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery [Otolaryngol Head Neck Surg] 2016 Nov; Vol. 155 (5), pp. 856-862. Date of Electronic Publication: 2016 Aug 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8508176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6817 (Electronic) Linking ISSN: 01945998 NLM ISO Abbreviation: Otolaryngol Head Neck Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Oxford] : Wiley Original Publication: [Rochester, Minn.] : The Academy, [c1981- |
| مواضيع طبية MeSH: | Environmental Exposure/*adverse effects , Otitis Media/*epidemiology , Otitis Media/*genetics , alpha-Macroglobulins/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Microbiota ; Otitis Media/microbiology ; Otoscopy ; Philippines/epidemiology ; Prevalence ; Risk Factors |
| مستخلص: | Objective: To identify genetic and environmental risk factors for otitis media in an indigenous Filipino population. Study Design: Cross-sectional study. Setting: Indigenous Filipino community. Subjects and Methods: Clinical history and information on breastfeeding, tobacco smoke exposure, and swimming were obtained from community members. Heads of households were interviewed for family history and personal beliefs on ear health. Height and weight were measured. Otoscopic findings were described for the presence and character of perforation or discharge. An A2ML1 duplication variant that confers otitis media susceptibility was Sanger sequenced in all DNA samples. Co-occurrence of middle ear bacteria detected by 16S rRNA gene sequencing was determined according to A2ML1 genotype and social cluster. Results: The indigenous Filipino population has a ~50% prevalence of otitis media. Young age was associated with otitis media (4 age strata; P = .004); however, age was nonsignificant as a bistratal or continuous variable. There was no association between otitis media and sex, body mass index, breastfeeding, tobacco exposure, or deep swimming. In multivariate analyses, A2ML1 genotype is the strongest predictor of otitis media, with an odds ratio of 3.7 (95% confidence interval: 1.3-10.8; P = .005). When otitis media diagnoses were plotted across ages, otitis media was observed within the first year of life, and chronic otitis media persisted up to adulthood, particularly in A2ML1-variant carriers. Conclusion: Among indigenous Filipinos, A2ML1 genotype is the primary risk factor for otitis media and main determinant of disease progression, although age, the middle ear microbiome, and social clusters might modulate the effect of the A2ML1 genotype. Competing Interests: Competing interests: None. Sponsorships: None. Funding source: This study was funded by grants from the University of the Philippines Manila – National Institutes of Health (to G.T.A.); the Albert and Margaret Alkek Foundation (to J.F.P.); the National Institute on Deafness and Other Communication Disorders at the United States National Institutes of Health (grants R01 DC011651 and R01 DC003594 to S.M.L. and R01 DC015004 to R.L.P.S.C.); and the National Organization for Hearing Research, Action for Hearing Loss and the Hearing Health Foundation (to R.L.P.S.C.). (© American Academy of Otolaryngology—Head and Neck Surgery Foundation 2016.) |
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| معلومات مُعتمدة: | R01 DC003594 United States DC NIDCD NIH HHS; R01 DC011651 United States DC NIDCD NIH HHS; R01 DC015004 United States DC NIDCD NIH HHS |
| فهرسة مساهمة: | Keywords: A2ML1; Philippines; indigenous population; microbiome; middle ear; otitis media |
| المشرفين على المادة: | 0 (A2ML1 protein, human) 0 (alpha-Macroglobulins) |
| تواريخ الأحداث: | Date Created: 20160804 Date Completed: 20170720 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5093071 |
| DOI: | 10.1177/0194599816661703 |
| PMID: | 27484237 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-6817 |
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| DOI: | 10.1177/0194599816661703 |