دورية أكاديمية
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Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans.

التفاصيل البيبلوغرافية
العنوان: Mechanosensory Neuron Aging: Differential Trajectories with Lifespan-Extending Alaskan Berry and Fungal Treatments in Caenorhabditis elegans.
المؤلفون: Scerbak C; Institute of Arctic Biology, University of Alaska FairbanksFairbanks, AK, USA; Department of Biology and Wildlife, University of Alaska FairbanksFairbanks, AK, USA; Department of Biology, Earlham CollegeRichmond, IN, USA., Vayndorf EM; Institute of Arctic Biology, University of Alaska Fairbanks Fairbanks, AK, USA., Hernandez A; Department of Biology and Wildlife, University of Alaska Fairbanks Fairbanks, AK, USA., McGill C; Chemistry Department, University of Alaska Anchorage Anchorage, AK, USA., Taylor BE; Institute of Arctic Biology, University of Alaska FairbanksFairbanks, AK, USA; Department of Biology and Wildlife, University of Alaska FairbanksFairbanks, AK, USA.
المصدر: Frontiers in aging neuroscience [Front Aging Neurosci] 2016 Jul 18; Vol. 8, pp. 173. Date of Electronic Publication: 2016 Jul 18 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Many nutritional interventions that increase lifespan are also proposed to postpone age-related declines in motor and cognitive function. Potential sources of anti-aging compounds are the plants and fungi that have adapted to extreme environments. We studied the effects of four commonly consumed and culturally relevant Interior Alaska berry and fungus species (bog blueberry, lowbush cranberry, crowberry, and chaga) on the decline in overall health and neuron function and changes in touch receptor neuron morphology associated with aging. We observed increased wild-type Caenorhabditis elegans lifespan and improved markers of healthspan upon treatment with Alaskan blueberry, lowbush cranberry, and chaga extracts. Interestingly, although all three treatments increased lifespan, they differentially affected the development of aberrant morphologies in touch receptor neurons. Blueberry treatments decreased anterior mechanosensory neuron (ALM) aberrations (i.e., extended outgrowths and abnormal cell bodies) while lowbush cranberry treatment increased posterior mechanosensory neuron (PLM) aberrations, namely process branching. Chaga treatment both decreased ALM aberrations (i.e., extended outgrowths) and increased PLM aberrations (i.e., process branching and loops). These results support the large body of knowledge positing that there are multiple cellular strategies and mechanisms for promoting health with age. Importantly, these results also demonstrate that although an accumulation of abnormal neuron morphologies is associated with aging and decreased health, not all of these morphologies are detrimental to neuronal and organismal health.
التعليقات: Erratum in: Front Aging Neurosci. 2017 May 23;9:158. (PMID: 28539886)
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معلومات مُعتمدة: TL4 GM118992 United States GM NIGMS NIH HHS; P40 OD010440 United States OD NIH HHS; UL1 GM118991 United States GM NIGMS NIH HHS; RL5 GM118990 United States GM NIGMS NIH HHS; P20 GM103395 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: C. elegans neuron aging; blueberry; chaga; crowberry; lowbush cranberry; mechanosensory neuron; neuron morphology; nutrition
تواريخ الأحداث: Date Created: 20160804 Date Completed: 20160803 Latest Revision: 20231111
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4947587
DOI: 10.3389/fnagi.2016.00173
PMID: 27486399
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-4365
DOI:10.3389/fnagi.2016.00173