دورية أكاديمية
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Contributions of the Central Extended Amygdala to Fear and Anxiety.

التفاصيل البيبلوغرافية
العنوان: Contributions of the Central Extended Amygdala to Fear and Anxiety.
المؤلفون: Shackman AJ; Department of Psychology, Neuroscience and Cognitive Science Program, and Maryland Neuroimaging Center, University of Maryland, College Park, Maryland 20742, and shackman@umd.edu fox.drew@gmail.com., Fox AS; Department of Psychology and California National Primate Research Center, University of California, Davis, California 95616 shackman@umd.edu fox.drew@gmail.com.
المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2016 Aug 03; Vol. 36 (31), pp. 8050-63.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
أسماء مطبوعة: Publication: Washington, DC : Society for Neuroscience
Original Publication: [Baltimore, Md.] : The Society, c1981-
مواضيع طبية MeSH: Anxiety/*physiopathology , Anxiety/*psychology , Basolateral Nuclear Complex/*physiopathology , Central Amygdaloid Nucleus/*physiopathology , Fear/*psychology , Nerve Net/*physiopathology, Animals ; Evidence-Based Medicine ; Expressed Emotion ; Humans ; Models, Neurological ; Primates
مستخلص: It is widely thought that phasic and sustained responses to threat reflect dissociable circuits centered on the central nucleus of the amygdala (Ce) and the bed nucleus of the stria terminalis (BST), the two major subdivisions of the central extended amygdala. Early versions of this hypothesis remain highly influential and have been incorporated into the National Institute of Mental Health Research Research Domain Criteria framework. However, new observations encourage a different perspective. Anatomical studies show that the Ce and BST form a tightly interconnected unit, where different kinds of threat-relevant information can be integrated and used to assemble states of fear and anxiety. Imaging studies in humans and monkeys show that the Ce and BST exhibit similar functional profiles. Both regions are sensitive to a range of aversive challenges, including uncertain or temporally remote threat; both covary with concurrent signs and symptoms of fear and anxiety; both show phasic responses to short-lived threat; and both show heightened activity during sustained exposure to diffusely threatening contexts. Mechanistic studies demonstrate that both regions can control the expression of fear and anxiety during sustained exposure to diffuse threat. These observations compel a reconsideration of the central extended amygdala's contributions to fear and anxiety and its role in neuropsychiatric disease.
(Copyright © 2016 the authors 0270-6474/16/368050-14$15.00/0.)
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معلومات مُعتمدة: R01 MH107444 United States MH NIMH NIH HHS; R21 DA040717 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: affective neuroscience; fMRI; fear and anxiety; mood and anxiety disorders; neuroimaging; nonhuman primates
تواريخ الأحداث: Date Created: 20160805 Date Completed: 20170710 Latest Revision: 20240327
رمز التحديث: 20240327
مُعرف محوري في PubMed: PMC4971357
DOI: 10.1523/JNEUROSCI.0982-16.2016
PMID: 27488625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-2401
DOI:10.1523/JNEUROSCI.0982-16.2016