دورية أكاديمية
Anti-Inflammatory and Anti-Oxidant Effects of p-Chloro-phenyl-selenoesterol on TNBS-Induced Inflammatory Bowel Disease in Mice.
| العنوان: | Anti-Inflammatory and Anti-Oxidant Effects of p-Chloro-phenyl-selenoesterol on TNBS-Induced Inflammatory Bowel Disease in Mice. |
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| المؤلفون: | Zarzecki MS; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., Bortolotto VC; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., Poetini MR; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., Araujo SM; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., de Paula MT; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., Roman SS; Universidade Regional Integrada, Campus Erechim, CEP 99700-000, Rio Grande do Sul, Brazil., Spiazzi C; Universidade Federal do Pampa, Campus Uruguaiana, CEP 97508-000, Rio Grande do Sul, Brazil., Cibin FW; Universidade Federal do Pampa, Campus Uruguaiana, CEP 97508-000, Rio Grande do Sul, Brazil., Rodrigues OE; Universidade Federal de Santa Maria, Campus Santa Maria, CEP 97105-900, Rio Grande do Sul, Brazil., Jesse CR; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil., Prigol M; Universidade Federal do Pampa, Campus Itaqui, CEP 97650-000, Rio Grande do Sul, Brazil. |
| المصدر: | Journal of cellular biochemistry [J Cell Biochem] 2017 Apr; Vol. 118 (4), pp. 709-717. Date of Electronic Publication: 2016 Dec 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8205768 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4644 (Electronic) Linking ISSN: 07302312 NLM ISO Abbreviation: J Cell Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004>- : Hoboken, NJ : Wiley-Liss Original Publication: New York : Liss, c1982- |
| مواضيع طبية MeSH: | Anti-Inflammatory Agents/*pharmacology , Antioxidants/*pharmacology , Inflammatory Bowel Diseases/*drug therapy , Organoselenium Compounds/*pharmacology, Animals ; Cytokines/biosynthesis ; Disease Models, Animal ; Female ; Inflammation Mediators/metabolism ; Inflammatory Bowel Diseases/metabolism ; Inflammatory Bowel Diseases/pathology ; Mice ; Oxidative Stress/drug effects ; Peroxidase/metabolism ; Trinitrobenzenesulfonic Acid/toxicity |
| مستخلص: | This study aims to investigate the protective effect of p-chloro-phenyl-selenoesterol [PCS; 0,2 mg/kg; 10 ml/kg i.g.) in colitis induced by 2,4,6-trinitrobenzene sulfonic acid [TNBS; 2 mg/100 µl 50% ethanol; intrarectally) in mice. Several parameters including weight, length, histological analyses determination, thiobarbituric acid reactive species, reactive species levels, superoxide dismutase, catalase, and myeloperoxidase (MPO) activity of colon were evaluated. The serum levels of tumor necrosis factor alpha [TNF-α) and interleukin 6 [IL-6) were also assessed. Treatment with PCS reduced the clinical and histopathologic severity of TNBS-induced colitis, characterized by colon length reduction and increased colon weight and microscopic intestinal inflammation. The therapeutic effects of PCS in this model were associated with significant decrease in proinflammatory cytokines TNF-α and IL-6 and decrease in MPO activity. Furthermore, combined with improvements in inflammatory parameters, treatment with the PCS was able to decrease oxidative stress and to prevent the decrease in antioxidant defenses in animals with TNBS-induced colitis. This finding suggests that PCS can improve experimental colitis in mice and it could be a potential therapeutic agent for the treatment of patients with IBD. J. Cell. Biochem. 118: 709-717, 2017. © 2016 Wiley Periodicals, Inc. (© 2016 Wiley Periodicals, Inc.) |
| فهرسة مساهمة: | Keywords: IBD; INFLAMMATION; KEYWORDS; OXIDATIVE STRESS; SELENIUM |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antioxidants) 0 (Cytokines) 0 (Inflammation Mediators) 0 (Organoselenium Compounds) 0 (p-chloro-phenyl-selenoesterol) 8T3HQG2ZC4 (Trinitrobenzenesulfonic Acid) EC 1.11.1.7 (Peroxidase) |
| تواريخ الأحداث: | Date Created: 20160807 Date Completed: 20171103 Latest Revision: 20220321 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1002/jcb.25670 |
| PMID: | 27496677 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1097-4644 |
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| DOI: | 10.1002/jcb.25670 |