Impact of Hepatitis C Virus/Schistosoma mansoni Coinfection on the Circulating Levels of HCV-NS4 Protein and Extracellular-Matrix Deposition in Patients with Different Hepatic Fibrosis Stages.

التفاصيل البيبلوغرافية
العنوان:	Impact of Hepatitis C Virus/Schistosoma mansoni Coinfection on the Circulating Levels of HCV-NS4 Protein and Extracellular-Matrix Deposition in Patients with Different Hepatic Fibrosis Stages.
المؤلفون:	Attallah AM; Biotechnology Research Center, New Damietta, Egypt. amattallah@hotmail.com., Abdallah SO; Faculty of Science, Cairo University, Giza, Egypt., Albannan MS; Biotechnology Research Center, New Damietta, Egypt., Omran MM; Faculty of Science, Helwan University, Cairo, Egypt., Attallah AA; Biotechnology Research Center, New Damietta, Egypt., Farid K; Faculty of Medicine, Mansoura University, Mansoura, Egypt.
المصدر:	The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2016 Nov 02; Vol. 95 (5), pp. 1044-1050. Date of Electronic Publication: 2016 Aug 15.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE
أسماء مطبوعة:	Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore.
مواضيع طبية MeSH:	Coinfection/parasitology , Coinfection/virology , Extracellular Matrix Proteins/metabolism , Liver Cirrhosis/parasitology , Liver Cirrhosis/virology , Viral Nonstructural Proteins/blood, Adult ; Alanine Transaminase/blood ; Alkaline Phosphatase/blood ; Animals ; Aspartate Aminotransferases/blood ; Cohort Studies ; Collagen Type III/genetics ; Collagen Type III/metabolism ; Disease Progression ; Egypt ; Extracellular Matrix Proteins/genetics ; Female ; Hepacivirus/isolation & purification ; Humans ; Logistic Models ; Male ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 1/metabolism ; Middle Aged ; Risk Factors ; Schistosoma mansoni/isolation & purification
مستخلص:	Hepatitis C virus (HCV)/Schistosoma mansoni coinfection is common in Egypt and other developing countries. This study aimed to investigate the influence of HCV/S. mansoni coinfection on the concentration of HCV-nonstructural protein-4 (NS4) in addition to collagen III and matrix metalloproteinase-1 (MMP-1) in different hepatic fibrosis stages. We found that coinfected patients (N = 186) showed significantly (P < 0.05, Mann-Whitney U test) higher concentrations of HCV-NS4, collagen III, and collagen III/MMP-1 ratio (CMR) than those with HCV monoinfection (N = 104) in different fibrosis stages. Conversely, coinfected patients showed significantly lower concentrations of MMP-1 when compared with HCV monoinfection. The elevated levels of CMR in case of HCV monoinfection yielded an estimated odds ratio of 1.8 and 2.6 for developing significant fibrosis (F2-F4) and cirrhosis (F4), respectively. HCV/S. mansoni coinfection increased the risk for developing F2-F4 and F4 several fold yielding an estimated odds ratio of 11.1 and 5.2, respectively. This means that coinfected patients have a 6-fold and 2-fold increased risk of developing F2-F4 and F4, respectively, over HCV-monoinfected patients. Thus, elevated levels of HCV-NS4 and CMR in HCV/S. mansoni coinfection suggest increased susceptibility of coinfected patients, compared with those with HCV monoinfection, for accelerating hepatic fibrosis progression. (© The American Society of Tropical Medicine and Hygiene.)
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المشرفين على المادة:	0 (Collagen Type III) 0 (Extracellular Matrix Proteins) 0 (NS4 protein, hepatitis C virus) 0 (Viral Nonstructural Proteins) EC 2.6.1.1 (Aspartate Aminotransferases) EC 2.6.1.2 (Alanine Transaminase) EC 3.1.3.1 (Alkaline Phosphatase) EC 3.4.24.7 (MMP1 protein, human) EC 3.4.24.7 (Matrix Metalloproteinase 1)
تواريخ الأحداث:	Date Created: 20160817 Date Completed: 20170601 Latest Revision: 20240601
رمز التحديث:	20240601
مُعرف محوري في PubMed:	PMC5094215
DOI:	10.4269/ajtmh.16-0129
PMID:	27527625
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1476-1645
DOI:	10.4269/ajtmh.16-0129