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Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil.

التفاصيل البيبلوغرافية
العنوان: Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil.
المؤلفون: Souto AC; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Bonfietti LX; Institute Adolfo Lutz, São Paulo, Brazil., Ferreira-Paim K; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity, Sydney Medical School-Westmead Hospital, The University of Sydney, The Westmead Institute for Medical Research, Sydney, Australia.; Infectious Disease Department, Triângulo Mineiro Federal University, Uberaba, Brazil., Trilles L; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity, Sydney Medical School-Westmead Hospital, The University of Sydney, The Westmead Institute for Medical Research, Sydney, Australia., Martins M; Institute Adolfo Lutz, São Paulo, Brazil., Ribeiro-Alves M; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Pham CD; Centers for Disease Control and Prevention, Atlanta, United States of America., Martins L; University of Piauí State, Teresina, Brazil., Dos Santos W; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity, Sydney Medical School-Westmead Hospital, The University of Sydney, The Westmead Institute for Medical Research, Sydney, Australia.; Federal University of Pará, Belém, Brazil., Chang M; Federal University of Mato Grosso do Sul, Campo Grande, Brazil., Brito-Santos F; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Santos DC; Institute Adolfo Lutz, São Paulo, Brazil., Fortes S; Biodiversity Research Center, Federal University of Roraima, Boa Vista, Brazil., Lockhart SR; Centers for Disease Control and Prevention, Atlanta, United States of America., Wanke B; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Melhem MS; Institute Adolfo Lutz, São Paulo, Brazil., Lazéra MS; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Meyer W; Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Marie Bashir Institute for Emerging Infectious Diseases and Biosecurity, Sydney Medical School-Westmead Hospital, The University of Sydney, The Westmead Institute for Medical Research, Sydney, Australia.
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Aug 16; Vol. 10 (8), pp. e0004885. Date of Electronic Publication: 2016 Aug 16 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Genetic Variation*, Cryptococcus gattii/*genetics, Biological Evolution ; Brazil/epidemiology ; Cryptococcosis/epidemiology ; Cryptococcosis/microbiology ; Cryptococcus gattii/classification ; Cryptococcus gattii/isolation & purification ; Cryptococcus neoformans/classification ; Cryptococcus neoformans/genetics ; Genotype ; Humans ; Multilocus Sequence Typing ; Mycological Typing Techniques ; North America/epidemiology ; Phylogeography ; Rainforest ; Recombination, Genetic ; South America/epidemiology
مستخلص: Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adaptation to temperate regions was crucial in the species evolution and highlighted the importance of this pathogenic yeast in the context of disease. Cryptococcus gattii molecular type VGII has come to the forefront in connection with an on-going emergence in the Pacific North West of North America. Taking into account that previous work pointed towards South America as an origin of this species, the present work aimed to assess the genetic diversity within the Brazilian C. gattii VGII population in order to gain new insights into its origin and global dispersal from the South American continent using the ISHAM consensus MLST typing scheme. Our results corroborate the finding that the Brazilian C. gattii VGII population is highly diverse. The diversity is likely due to recombination generated from sexual reproduction, as evidenced by the presence of both mating types in clinical and environmental samples. The data presented herein strongly supports the emergence of highly virulent strains from ancestors in the Northern regions of Brazil, Amazonia and the Northeast. Numerous genotypes represent a link between Brazil and other parts of the world reinforcing South America as the most likely origin of the C. gattii VGII subtypes and their subsequent global spread, including their dispersal into North America, where they caused a major emergence.
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تواريخ الأحداث: Date Created: 20160817 Date Completed: 20170719 Latest Revision: 20201209
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC4986980
DOI: 10.1371/journal.pntd.0004885
PMID: 27529479
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0004885