دورية أكاديمية
أعرض في EDS

Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats.

التفاصيل البيبلوغرافية
العنوان: Association of exercise training and angiotensin-converting enzyme 2 activator improves baroreflex sensitivity of spontaneously hypertensive rats.
المؤلفون: Lopes PR; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Moreira MC; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Marques SM; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Pinto IS; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Macedo LM; Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Silva CC; Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Freiria-Oliveira AH; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Rebelo AC; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Reis AA; Departamento de Bioquímica e Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Rosa DA; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Ferreira-Neto ML; Faculdade de Educação Física, Universidade Federal de Uberlândia, Uberlândia, MG, Brasil., Castro CH; Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil., Pedrino GR; Centro de Pesquisas em Neurociência e Fisiologia Cardiovascular, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brasil.
المصدر: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas [Braz J Med Biol Res] 2016 Aug 01; Vol. 49 (9), pp. e5349. Date of Electronic Publication: 2016 Aug 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Associação Brasileira de Divulgação Científica Country of Publication: Brazil NLM ID: 8112917 Publication Model: Electronic Cited Medium: Internet ISSN: 1414-431X (Electronic) Linking ISSN: 0100879X NLM ISO Abbreviation: Braz J Med Biol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [SP, Brasil : Associação Brasileira de Divulgação Científica, 1981-
مواضيع طبية MeSH: Baroreflex/*drug effects , Diminazene/*analogs & derivatives , Hypertension/*drug therapy , Peptidyl-Dipeptidase A/*pharmacology , Physical Conditioning, Animal/*physiology, Angiotensin-Converting Enzyme 2 ; Animals ; Blood Pressure/physiology ; Diminazene/agonists ; Diminazene/pharmacology ; Heart Rate/physiology ; Hypertension/physiopathology ; Male ; Rats ; Rats, Inbred SHR ; Signal Transduction/drug effects
مستخلص: The present study sought to determine cardiovascular effects of aerobic training associated with diminazene aceturate (DIZE), an activator of the angiotensin converting enzyme 2, in spontaneously hypertensive rats (SHRs). Male SHRs (280-350 g) were either subjected to exercise training or not (sedentary group). The trained group was subjected to 8 weeks of aerobic training on a treadmill (five times a week, lasting 60 min at an intensity of 50-60% of maximum aerobic speed). In the last 15 days of the experimental protocol, these groups were redistributed into four groups: i) sedentary SHRs with daily treatment of 1 mg/kg DIZE (S+D1); ii) trained SHRs with daily treatment of 1 mg/kg DIZE (T+D1); iii) sedentary SHRs with daily treatment of vehicle (S+V); and iv) trained SHRs with daily treatment of vehicle (T+V). After treatment, SHRs were anesthetized and subjected to artery and femoral vein cannulation prior to the implantation of ECG electrode. After 24 h, mean arterial pressure (MAP) and heart rate (HR) were recorded; the baroreflex sensitivity and the effect of double autonomic blockade (DAB) were evaluated in non-anesthetized SHRs. DIZE treatment improved baroreflex sensitivity in the T+D1 group as compared with the T+V and S+D1 groups. The intrinsic heart rate (IHR) and MAP were reduced in T+D1 group as compared with T+V and S+D1 groups. Hence, we conclude that the association of exercise training with DIZE treatment improved baroreflex function and cardiovascular regulation.
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المشرفين على المادة: EC 3.4.15.1 (Peptidyl-Dipeptidase A)
EC 3.4.17.23 (Ace2 protein, rat)
EC 3.4.17.23 (Angiotensin-Converting Enzyme 2)
JI8SAD85NO (diminazene aceturate)
Y5G36EEA5Z (Diminazene)
تواريخ الأحداث: Date Created: 20160818 Date Completed: 20170405 Latest Revision: 20201209
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC4988479
DOI: 10.1590/1414-431X20165349
PMID: 27533767
قاعدة البيانات: MEDLINE
الوصف
تدمد:1414-431X
DOI:10.1590/1414-431X20165349