دورية أكاديمية
Donovanosis and squamous cell carcinoma: The relationship conundrum!
| العنوان: | Donovanosis and squamous cell carcinoma: The relationship conundrum! |
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| المؤلفون: | Arora AK; 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Kumaran MS; 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Narang T; 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Saikia UN; 2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Handa S; 1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. |
| المصدر: | International journal of STD & AIDS [Int J STD AIDS] 2017 Mar; Vol. 28 (4), pp. 411-414. Date of Electronic Publication: 2016 Aug 20. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Dec. 2012- : London : Sage Original Publication: London, U.K. : Royal Society of Medicine Services, c1990- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell/*diagnostic imaging , Doxycycline/*administration & dosage , Granuloma Inguinale/*diagnosis , Granuloma Inguinale/*diagnostic imaging , Ulcer/*diagnostic imaging, Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/therapeutic use ; Biopsy ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/pathology ; Granuloma Inguinale/drug therapy ; Granuloma Inguinale/pathology ; Humans ; Male ; Penis/pathology ; Ulcer/drug therapy ; Ulcer/pathology |
| مستخلص: | Donovanosis is a rare, chronic and indolent sexually transmitted infection caused by Klebsiella granulomatis. The ulcers in donovanosis rarely undergo malignant transformation, which is usually seen in longstanding ulcers. We present a case of a 32-year-old male who presented with a two-month history of rapidly progressive, large, foul-smelling ulcers over the groin, distal penile shaft and scrotum. Crushed tissue smears from ulcers revealed basophilic intracellular and extracellular Donovan bodies. Fine needle aspiration cytology from inguinal lymph nodes and biopsy from the ulcers revealed well-differentiated squamous cell carcinoma. The current case aims to alert clinicians that donovanosis is a rare but possible cause of cutaneous malignancy. Nonetheless, the pathogenesis of malignant transformation in donovanosis needs further research. |
| فهرسة مساهمة: | Keywords: Donovan bodies; Donovanosis; granuloma inguinale; malignancy; squamous cell carcinoma |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) N12000U13O (Doxycycline) |
| تواريخ الأحداث: | Date Created: 20160819 Date Completed: 20180314 Latest Revision: 20180321 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/0956462416665996 |
| PMID: | 27535727 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1758-1052 |
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| DOI: | 10.1177/0956462416665996 |