دورية أكاديمية
أعرض في EDS

Cycloid psychoses in the psychosis spectrum: evidence for biochemical differences with schizophrenia.

التفاصيل البيبلوغرافية
العنوان: Cycloid psychoses in the psychosis spectrum: evidence for biochemical differences with schizophrenia.
المؤلفون: van de Kerkhof NW; Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray; Department of Psychiatry., Fekkes D; Department of Psychiatry; Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Heijden FM; Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray., Hoogendijk WJ; Department of Psychiatry., Stöber G; Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany., Egger JI; Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray; Behavioural Science Institute; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands., Verhoeven WM; Vincent van Gogh Institute for Psychiatry, Centre of Excellence for Neuropsychiatry, Venray; Department of Psychiatry.
المصدر: Neuropsychiatric disease and treatment [Neuropsychiatr Dis Treat] 2016 Aug 02; Vol. 12, pp. 1927-33. Date of Electronic Publication: 2016 Aug 02 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101240304 Publication Model: eCollection Cited Medium: Print ISSN: 1176-6328 (Print) Linking ISSN: 11766328 NLM ISO Abbreviation: Neuropsychiatr Dis Treat Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Albany, Auckland, N.Z. : Dove Medical Press, c2005-
مستخلص: Cycloid psychoses (CP) differ from schizophrenia regarding symptom profile, course, and prognosis and over many decades they were thought to be a separate entity within the psychosis spectrum. As to schizophrenia, research into the pathophysiology has focused on dopamine, brain-derived neurotrophic factor, and glutamate signaling in which, concerning the latter, the N-methyl-d-aspartate receptor plays a crucial role. The present study aims to determine whether CP can biochemically be delineated from schizophrenia. Eighty patients referred for psychotic disorders were assessed with the Comprehensive Assessment of Symptoms and History, and (both at inclusion and after 6 weeks of antipsychotic treatment) with the Positive and Negative Syndrome Scale and Clinical Global Impression. From 58 completers, 33 patients were diagnosed with schizophrenia and ten with CP according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and Leonhard criteria, respectively. Fifteen patients were diagnosed with other disorders within the psychosis spectrum. At both time points, blood levels of the dopamine metabolite homovanillic acid, brain-derived neurotrophic factor, and amino acids related to glutamate neurotransmission were measured and compared with a matched control sample. Patients with CP showed a significantly better response to antipsychotic treatment as compared to patients with schizophrenia. In CP, glycine levels were elevated and tryptophan levels were lowered as compared to schizophrenia. Glutamate levels were increased in both patient groups as compared to controls. These results, showing marked differences in both treatment outcome and glutamate-related variable parameters, may point at better neuroplasticity in CP, necessitating demarcation of this subgroup within the psychosis spectrum.
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فهرسة مساهمة: Keywords: cycloid psychoses; glutamate; glycine; neuroplasticity; schizophrenia; tryptophan
تواريخ الأحداث: Date Created: 20160819 Date Completed: 20160818 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC4977096
DOI: 10.2147/NDT.S101317
PMID: 27536115
قاعدة البيانات: MEDLINE
الوصف
تدمد:1176-6328
DOI:10.2147/NDT.S101317