دورية أكاديمية
Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis.
| العنوان: | Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis. |
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| المؤلفون: | Amm HM; Institute of Oral Health Research, University of Alabama at Birmingham School of Dentistry, Birmingham, AL 35294, USA., MacDougall M; Institute of Oral Health Research, University of Alabama at Birmingham School of Dentistry, Birmingham, AL 35294, USA. |
| المصدر: | Current oral health reports [Curr Oral Health Rep] 2016 Jun; Vol. 3 (2), pp. 82-92. Date of Electronic Publication: 2016 Mar 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Publishing AG Country of Publication: Switzerland NLM ID: 101626542 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2196-3002 (Print) NLM ISO Abbreviation: Curr Oral Health Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Switzerland] : Springer International Publishing AG, [2014]- |
| مستخلص: | Several molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. In this review, we focus on two of the most common odontogenic tumor subtypes: ameloblastoma and keratocystic odontogenic tumors. We highlight gene expression and protein immunohistological findings and known genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor, Wnt and Akt signaling pathways relevant to these tumors. These various pathways are explored to potentially target odontogenic tumors cells and prevent growth and recurrence of disease. Through an understanding of these signaling pathways and their crosstalk, molecular diagnostics may emerge as well as the ability to exploit identified molecular differences to develop novel molecular therapeutics for the treatment of odontogenic tumors. |
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| معلومات مُعتمدة: | K99 DE023826 United States DE NIDCR NIH HHS; T90 DE022736 United States DE NIDCR NIH HHS |
| فهرسة مساهمة: | Keywords: BRAF; ameloblastoma; epidermal growth factor receptor; hedgehog; odontogenic tumors |
| تواريخ الأحداث: | Date Created: 20160823 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC4988688 |
| DOI: | 10.1007/s40496-016-0085-z |
| PMID: | 27547697 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2196-3002 |
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| DOI: | 10.1007/s40496-016-0085-z |