دورية أكاديمية
أعرض في EDS

Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.

التفاصيل البيبلوغرافية
العنوان: Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.
المؤلفون: Jaszczak JS; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908., Wolpe JB; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908., Bhandari R; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908., Jaszczak RG; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908., Halme A; Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 ajh6a@virginia.edu.
المصدر: Genetics [Genetics] 2016 Oct; Vol. 204 (2), pp. 703-709. Date of Electronic Publication: 2016 Aug 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Austin, Tex. [etc.]
مواضيع طبية MeSH: Drosophila Proteins/*genetics , Imaginal Discs/*growth & development , Intercellular Signaling Peptides and Proteins/*genetics , RNA-Binding Proteins/*genetics , Receptors, G-Protein-Coupled/*genetics, Animals ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Ecdysone/genetics ; Ecdysone/metabolism ; Gene Expression Regulation, Developmental ; Imaginal Discs/metabolism ; Larva/growth & development ; Neurons/metabolism ; Regeneration/genetics ; Signal Transduction
مستخلص: Damage to Drosophila melanogaster imaginal discs activates a regeneration checkpoint that (1) extends larval development and (2) coordinates the regeneration of the damaged disc with the growth of undamaged discs. These two systemic responses to damage are both mediated by Dilp8, a member of the insulin/insulin-like growth factor/relaxin family of peptide hormones, which is released by regenerating imaginal discs. Growth coordination between regenerating and undamaged imaginal discs is dependent on Dilp8 activation of nitric oxide synthase (NOS) in the prothoracic gland (PG), which slows the growth of undamaged discs by limiting ecdysone synthesis. Here we demonstrate that the Drosophila relaxin receptor homolog Lgr3, a leucine-rich repeat-containing G-protein-coupled receptor, is required for Dilp8-dependent growth coordination and developmental delay during the regeneration checkpoint. Lgr3 regulates these responses to damage via distinct mechanisms in different tissues. Using tissue-specific RNA-interference disruption of Lgr3 expression, we show that Lgr3 functions in the PG upstream of NOS, and is necessary for NOS activation and growth coordination during the regeneration checkpoint. When Lgr3 is depleted from neurons, imaginal disc damage no longer produces either developmental delay or growth inhibition. To reconcile these discrete tissue requirements for Lgr3 during regenerative growth coordination, we demonstrate that Lgr3 activity in both the CNS and PG is necessary for NOS activation in the PG following damage. Together, these results identify new roles for a relaxin receptor in mediating damage signaling to regulate growth and developmental timing.
(Copyright © 2016 by the Genetics Society of America.)
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معلومات مُعتمدة: R01 GM099803 United States GM NIGMS NIH HHS; T32 GM008136 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: Lgr3; checkpoint; growth coordination; regeneration
المشرفين على المادة: 0 (Drosophila Proteins)
0 (Intercellular Signaling Peptides and Proteins)
0 (Lgr3 protein, Drosophila)
0 (RNA-Binding Proteins)
0 (Receptors, G-Protein-Coupled)
0 (insulin-like peptide 8, Drosophila)
142661-95-8 (nos protein, Drosophila)
3604-87-3 (Ecdysone)
تواريخ الأحداث: Date Created: 20160826 Date Completed: 20170523 Latest Revision: 20190523
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5068856
DOI: 10.1534/genetics.116.193706
PMID: 27558136
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-2631
DOI:10.1534/genetics.116.193706