دورية أكاديمية
Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease.
| العنوان: | Value of 18F-FDG PET/CT in diagnosing chronic Q fever in patients with central vascular disease. |
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| المؤلفون: | Hagenaars JC; Department of Surgery, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands., Wever PC, Vlake AW, Renders NH, van Petersen AS, Hilbink M, de Jager-Leclercq MG, Moll FL, Koning OH, Hoekstra CJ |
| المصدر: | The Netherlands journal of medicine [Neth J Med] 2016 Aug; Vol. 74 (7), pp. 301-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Van Zuiden Communications Country of Publication: Netherlands NLM ID: 0356133 Publication Model: Print Cited Medium: Internet ISSN: 1872-9061 (Electronic) Linking ISSN: 03002977 NLM ISO Abbreviation: Neth J Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Alphen aan de Rijn, The Netherlands : Van Zuiden Communications Original Publication: Haarlem, Bohn |
| مواضيع طبية MeSH: | Aortic Aneurysm, Abdominal/*diagnostic imaging , Aortic Diseases/*diagnostic imaging , Blood Vessel Prosthesis/*microbiology , Iliac Artery/*diagnostic imaging , Prosthesis-Related Infections/*diagnostic imaging , Q Fever/*diagnostic imaging, Aortic Aneurysm, Abdominal/microbiology ; Aortic Diseases/diagnosis ; Aortic Diseases/microbiology ; Coxiella burnetii/genetics ; DNA, Bacterial/analysis ; Fluorodeoxyglucose F18 ; Humans ; Iliac Artery/microbiology ; Iliac Artery/surgery ; Polymerase Chain Reaction ; Positron Emission Tomography Computed Tomography ; Prospective Studies ; Prosthesis-Related Infections/diagnosis ; Prosthesis-Related Infections/microbiology ; Q Fever/diagnosis ; Radiopharmaceuticals ; Retrospective Studies ; Sensitivity and Specificity ; Vascular Diseases/diagnosis ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/microbiology |
| مستخلص: | Background: The aim of this study is to describe the value of 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in diagnosing chronic Q fever in patients with central vascular disease and the added value of 18F-FDG PET/CT in the diagnostic combination strategy as described in the Dutch consensus guideline for diagnosing chronic Q fever. Methods: 18F-FDG PET/CT was performed in patients with an abdominal aortic aneurysm or aorto-iliac reconstruction and chronic Q fever, diagnosed by serology and positive PCR for Coxiella burnetii DNA in blood and/or tissue (PCR-positive study group). Patients with an abdominal aortic aneurysm or aorto-iliac reconstruction without clinical and serological findings indicating Q fever infection served as a control group. Patients with a serological profile of chronic Q fever and a negative PCR in blood were included in additional analyses (PCR-negative study group). Results: Thirteen patients were evaluated in the PCR-positive study group and 22 patients in the control group. 18F-FDG PET/CT indicated vascular infection in 6/13 patients in the PCR-positive study group and 2/22 patients in the control group. 18F-FDG PET/CT demonstrated a sensitivity of 46% (95% CI: 23-71%), specificity of 91% (95% CI: 71-99%), positive predictive value of 75% (95% CI:41-93%) and negative predictive value of 74% (95% CI: 55-87%). In the PCR-negative study group, 18F-FDG PET/CT was positive in 10/20 patients (50%). Conclusion: The combination of 18F-FDG PET/CT, as an imaging tool for identifying a focus of infection, and Q fever serology is a valid diagnostic strategy for diagnosing chronic Q fever in patients with central vascular disease. |
| المشرفين على المادة: | 0 (DNA, Bacterial) 0 (Radiopharmaceuticals) 0Z5B2CJX4D (Fluorodeoxyglucose F18) |
| تواريخ الأحداث: | Date Created: 20160831 Date Completed: 20170810 Latest Revision: 20170817 |
| رمز التحديث: | 20240829 |
| PMID: | 27571945 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1872-9061 |
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