دورية أكاديمية
Evaluation of Bone Mineral Density in Patients with Type 1 Gaucher Disease in Argentina.
| العنوان: | Evaluation of Bone Mineral Density in Patients with Type 1 Gaucher Disease in Argentina. |
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| المؤلفون: | Larroudé MS; Departamento de Densitometría ósea, Centro de Diagnóstico E. Rossi, Buenos Aires, Argentina; Departamento de Densitometría ósea, Hospital Cesar Milstein, Buenos Aires, Argentina. Electronic address: mlarroude@cdrossi.com., Aguilar G; Departamento de Densitometría ósea, Centro de Diagnóstico E. Rossi, Buenos Aires, Argentina., Rossi I; Departamento de Densitometría ósea, Centro de Diagnóstico E. Rossi, Buenos Aires, Argentina., Drelichman G; Hospital de Niños 'Ricardo Gutiérrez,' CABA, Buenos Aires, Argentina., Fernandez Escobar N; Hospital de Niños 'Ricardo Gutiérrez,' CABA, Buenos Aires, Argentina., Basack N; Hospital de Niños 'Ricardo Gutiérrez,' CABA, Buenos Aires, Argentina., Slago M; Department of Hematology, Laboratorio de Neuroquímica 'Dr. N.A. Chamoles,' Buenos Aires, Argentina., Schenone A; Department of Hematology, Laboratorio de Neuroquímica 'Dr. N.A. Chamoles,' Buenos Aires, Argentina., Fynn A; Department of Hematology, Hospital de Niños 'Sor María Ludovica,' La Plata, Argentina., Cuello MF; Department of Hematology, Hospital de Niños 'Sor María Ludovica,' La Plata, Argentina., Fernandez R; Department of Hematology, Hospital de Niños 'Sor María Ludovica,' La Plata, Argentina., Ruiz A; Department of Hematology, Hospital CEpsi Eva Perón, Santiago del Estero, Argentina., Reichel P; Department of Hematology, Hospital CEpsi Eva Perón, Santiago del Estero, Argentina., Guelbert N; Department of Hematology, Hospital Provincial de Niños 'Santa Trinidad,' Córdoba, Argentina., Robledo H; Department of Hematology, Hospital Provincial de Niños 'Santa Trinidad,' Córdoba, Argentina., Watman N; Hospital Ramos Mejía, CABA, Buenos Aires, Argentina., Bolesina M; Hospital Ramos Mejía, CABA, Buenos Aires, Argentina., Elena G; Hospital de Niños Pedro de Elizalde, CABA, Buenos Aires, Argentina., Veber SE; Hospital de Niños Pedro de Elizalde, CABA, Buenos Aires, Argentina., Pujal G; Department of Hematology, Hospital 'Dr. Julio C. Perrando,' Chaco, Argentina., Galvan G; Department of Hematology, Hospital 'Dr. Julio C. Perrando,' Chaco, Argentina., Chain JJ; Department of Hematology, Hospital del Niño Jesús, Tucumán, Argentina., Arizo A; Department of Hematology, Hospital Iturraspe, Santa Fe, Argentina., Bietti J; Department of Hematology, Hospital Iturraspe, Santa Fe, Argentina., Aznar M; Department of Hematology, Instituto Médico Platense, La Plata, Argentina., Dragosky M; Department of Hematology, Hospital de Oncología 'M. Curie,' Buenos Aires, Argentina., Marquez M; Department of Hematology, Hospital de Oncología 'M. Curie,' Buenos Aires, Argentina., Feldman L; Clínica Modelo de Tandil, Pcia, Buenos Aires, Argentina., Muller K; Clínica Modelo de Tandil, Pcia, Buenos Aires, Argentina., Zirone S; Department of Hematology, Clínica del Niño del Rosario, Santa Fe, Argentina., Buchovsky G; Department of Hematology, Hospital Escuela de Corrientes, Corrientes, Argentina., Lanza V; Hospital Materno Infantil de Mar del Plata, Pcia, Buenos Aires, Argentina., Fernandez I; Hospital de Del Viso, Pcia, Buenos Aires, Argentina., Jaureguiberry R; Department of Hematology, Hospital de San Martín, La Plata, Argentina., Barbieri MA; Hospital Alemán, CABA, Buenos Aires, Argentina., Maro A; Hospital Alemán, CABA, Buenos Aires, Argentina., Zarate G; Hospital Pirovano, CABA, Buenos Aires, Argentina., Fernandez G; Hospital Pirovano, CABA, Buenos Aires, Argentina., Rapetti M; Hospital de Niños de San Justo, Pcia, Buenos Aires, Argentina., Degano A; Sanatorio General Sarmiento, Pcia, Buenos Aires, Argentina., Kantor G; Hospital Durand, CABA, Buenos Aires, Argentina., Albina A; Consultorio Particular, Mar Del Plata, Prov, Buenos Aires, Argentina., Alvarez Bollea M; Department of Hematology, Sanatorio Allende de Córdoba, Córdoba, Argentina., Arrocena H; Hospital Centenario, Gualeguychu, Entre Ríos, Argentina., Bacciedoni V; Department of Hematology, Hospital Lagomaggiore, Mendoza, Argentina., Del Rio F; Department of Hematology, Hospital Lagomaggiore, Mendoza, Argentina. |
| المصدر: | Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2016 Oct; Vol. 19 (4), pp. 444-449. Date of Electronic Publication: 2016 Aug 26. |
| نوع المنشور: | Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9808212 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1094-6950 (Print) Linking ISSN: 10946950 NLM ISO Abbreviation: J Clin Densitom Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Totowa, NJ : Humana Press, c1998- |
| مواضيع طبية MeSH: | Absorptiometry, Photon*/methods, Gaucher Disease/*complications , Osteoporosis/*complications , Osteoporosis/*diagnostic imaging, Adolescent ; Adult ; Aged ; Argentina/epidemiology ; Bone Density ; Bone Diseases, Metabolic/complications ; Bone Diseases, Metabolic/diagnostic imaging ; Bone Diseases, Metabolic/epidemiology ; Child ; Female ; Femur Neck/diagnostic imaging ; Gaucher Disease/epidemiology ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Male ; Middle Aged ; Osteoporosis/epidemiology ; Young Adult |
| مستخلص: | The purpose of this study was to evaluate the frequency of osteoporosis (OP) in patients with Gaucher disease (GD) in Argentina. GD patients from 28 centers were consecutively included from April 2012 to 2014. Bone mineral density (BMD) was determined by dual X-ray absorptiometry in the lumbar spine and the femoral neck or the total proximal femur for patients ≥20 yr of age, and by whole-body scan in the lumbar spine in patients <20 yr of age. In children, mineral density was calculated using the chronological age and Z height. OP diagnosis was determined following adult and pediatric official position of the International Society for Clinical Densitometry. A total of 116 patients were included, of which 62 (53.5%) were women. The median age was 25.8 yr. All patients received enzyme replacement therapy, with a median time of 9.4 yr. Normal BMD was found in 89 patients (76.7%), whereas low bone mass (LBM) or osteopenia was found in 15 patients (13%) and OP in 12 patients (10.3%). The analysis of the pediatric population revealed that 4 patients (9.3%) had LBM and 3 (7%) had OP (Z-score ≤ -2 + fractures height-adjusted by Z), whereas in the adult population (n = 73), 11 patients (15%) had LBM or osteopenia and 9 (12.3%) had OP. Bone marrow infiltration and the presence of fractures were significantly correlated with the presence of OP (p = 0.04 and <0.001, respectively). This is the first study in Argentina and in the region describing the frequency of OP or LBM in GD patients treated with imiglucerase using the official position of the International Society for Clinical Densitometry. (Copyright © 2016 International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Argentina; Gaucher disease; bone mineral density; osteoporosis |
| تواريخ الأحداث: | Date Created: 20160831 Date Completed: 20180126 Latest Revision: 20180830 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jocd.2016.07.003 |
| PMID: | 27574779 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1094-6950 |
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| DOI: | 10.1016/j.jocd.2016.07.003 |