دورية أكاديمية
[Protective effects of high-dose ulinastatin on vital organs in patients receiving total arch replacement for type A aortic dissection].
| العنوان: | [Protective effects of high-dose ulinastatin on vital organs in patients receiving total arch replacement for type A aortic dissection]. |
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| المؤلفون: | Wang XY; Department of Cardiovascular Surgery, the Military General Hospital of Guangzhou Command(affiliated hospital of the Second military medical university), Guangzhou, China 510010. E-mail: 37680138@qq.com., Dong WP, Tong G, Bi SH, Zhang B, Lu H, Wang XW, Zhang WD |
| المصدر: | Nan fang yi ke da xue xue bao = Journal of Southern Medical University [Nan Fang Yi Ke Da Xue Xue Bao] 2016 Aug 20; Vol. 36 (8), pp. 1085-9. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Nanfang yi ke da xue xue bao bian ji bu Country of Publication: China NLM ID: 101266132 Publication Model: Print Cited Medium: Print ISSN: 1673-4254 (Print) Linking ISSN: 16734254 NLM ISO Abbreviation: Nan Fang Yi Ke Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou : Nanfang yi ke da xue xue bao bian ji bu, 2005- |
| مواضيع طبية MeSH: | Aortic Dissection/*surgery , Aortic Aneurysm, Thoracic/*surgery , Glycoproteins/*therapeutic use , Protective Agents/*therapeutic use, Aorta, Thoracic/surgery ; Body Temperature ; Brain/drug effects ; Cardiopulmonary Bypass ; Cerebrovascular Circulation ; Humans ; Incidence ; Lactic Acid/blood ; Lung/drug effects ; Perfusion ; Phosphopyruvate Hydratase/blood ; Postoperative Period ; S100 Proteins/blood ; Time Factors |
| مستخلص: | Objective: To investigate the protective effects of high-dose ulinastatin on the vital organs in patients undergoing total arch replacement for type A aortic dissection. Methods: Between September 2014 and March 2016, 66 patients with type A aortic dissection underwent total arch replacement at our center. Thirty-six of the patients received ulinastatin treatment at 300 000 U/8 h from admission to 3 days postoperatively and at 300 000 U/2 h during cardiopulmonary bypass surgery (UTI group), and the other 30 patients did not receive perioperative ulinastatin treatment (control group). The surgical data and blood biochemistry profiles on days 1, 3, and 5 postoperatively were compared between the two groups, and the postoperative ICU stay, re-operation for bleeding, ventilation for over 7 days, ultrafiltration for postoperative renal failure, tracheotomy, incidences of pulmonary and neurological complications and hospital death were also compared. Results: s The operating time, cardiopulmonary bypass time, ACP time, cardiac arrest time, the lowest rectal temperature and frequency of bilateral and unilateral antegrade selective cerebral perfusion were similar between the two groups (P>0.05). Compared with those in the control group, patients in UTI group had lower lactate, S-100 and neuron specific enolase levels on the first postoperative day and higher OI on the 1st, 3rd, and 5th postoperative days (P<0.05), but serum creatinine, blood urea nitrogen, total bilirubin, and alanine aminotransferase levels were comparable between the two groups (P>0.05). No significant differences were found in the frequency of re-operation for bleeding, ultrafiltration for renal failure, tracheotomy, neurological complications or hospital death after the operation between the two groups, but the patients in UTI group had a shorter ICU time, a less frequent long-term ventilation and a lower incidence of pulmonary infection (P<0.05). Conclusion: High-dose ulinastatin offers protection on pulmonary function and lowers the specific brain injury markers in patients with type A aortic dissection after total arch replacement, but its protective effects on brain is uncertain. |
| المشرفين على المادة: | 0 (Glycoproteins) 0 (Protective Agents) 0 (S100 Proteins) 33X04XA5AT (Lactic Acid) EC 4.2.1.11 (Phosphopyruvate Hydratase) OR3S9IF86U (urinastatin) |
| تواريخ الأحداث: | Date Created: 20160901 Date Completed: 20171107 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| PMID: | 27578577 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1673-4254 |
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