دورية أكاديمية
أعرض في EDS

Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines.

التفاصيل البيبلوغرافية
العنوان: Cross-Linking Mast Cell Specific Gangliosides Stimulates the Release of Newly Formed Lipid Mediators and Newly Synthesized Cytokines.
المؤلفون: Filho EG; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil., da Silva EZ; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil., Zanotto CZ; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil., Oliver C; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil., Jamur MC; Department of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirão Preto Medical School, University of São Paulo, Avenida Bandeirantes 3900, 14049-900 Ribeirão Preto, SP, Brazil.
المصدر: Mediators of inflammation [Mediators Inflamm] 2016; Vol. 2016, pp. 9160540. Date of Electronic Publication: 2016 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 9209001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1466-1861 (Electronic) Linking ISSN: 09629351 NLM ISO Abbreviation: Mediators Inflamm Subsets: MEDLINE
أسماء مطبوعة: Publication: 2005- : Sylvania, OH : Hindawi Pub. Corp.
Original Publication: Oxford, UK : Rapid Communications of Oxford Ltd., c1992-
مواضيع طبية MeSH: Cytokines/*metabolism , Gangliosides/*metabolism , Mast Cells/*metabolism, Animals ; Cell Line ; Group IV Phospholipases A2/metabolism ; Immunoblotting ; Interleukin-4/metabolism ; Interleukin-6/metabolism ; Leukotrienes/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Mitogen-Activated Protein Kinase 8/metabolism ; Mitogen-Activated Protein Kinase 9/metabolism ; NF-kappa B/metabolism ; NFATC Transcription Factors/metabolism ; Phosphorylation ; Prostaglandins D/metabolism ; Prostaglandins E/metabolism ; Rats ; Tumor Necrosis Factor-alpha/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism
مستخلص: Mast cells are immunoregulatory cells that participate in inflammatory processes. Cross-linking mast cell specific GD1b derived gangliosides by mAbAA4 results in partial activation of mast cells without the release of preformed mediators. The present study examines the release of newly formed and newly synthesized mediators following ganglioside cross-linking. Cross-linking the gangliosides with mAbAA4 released the newly formed lipid mediators, prostaglandins D2 and E2, without release of leukotrienes B4 and C4. The effect of cross-linking these gangliosides on the activation of enzymes in the arachidonate cascade was then investigated. Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2. Translocation of 5-lipoxygenase from the cytosol to the nucleus was not induced by ganglioside cross-linking. Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-α. The effect of cross-linking the gangliosides on the MAP kinase pathway was then investigated. Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFκB and NFAT in a Syk-dependent manner. Therefore, cross-linking the mast cell specific GD1b derived gangliosides results in the activation of signaling pathways that culminate with the release of newly formed and newly synthesized mediators.
References: J Histochem Cytochem. 2014 Oct;62(10):698-738. (PMID: 25062998)
Int Immunol. 1996 May;8(5):731-6. (PMID: 8671661)
J Biol Chem. 1994 Feb 18;269(7):5249-54. (PMID: 8106508)
Cell Calcium. 2007 Aug;42(2):145-56. (PMID: 17572487)
Front Immunol. 2016 Jan 06;6:620. (PMID: 26779180)
J Biol Chem. 1986 Sep 5;261(25):11823-31. (PMID: 2943732)
J Biol Chem. 2010 Aug 20;285(34):26674-84. (PMID: 20554527)
J Histochem Cytochem. 2007 Apr;55(4):315-25. (PMID: 17164410)
Mol Immunol. 2009 Aug;46(13):2539-47. (PMID: 19540596)
Curr Opin Immunol. 2003 Dec;15(6):639-46. (PMID: 14630197)
J Immunol. 2007 Feb 15;178(4):2549-55. (PMID: 17277164)
Ann Neurol. 2003 May;53(5):570-9. (PMID: 12730990)
Mol Cell. 2000 Sep;6(3):539-50. (PMID: 11030334)
J Immunol. 1998 Aug 15;161(4):1795-802. (PMID: 9712046)
J Immunol. 1998 Oct 15;161(8):4366-74. (PMID: 9780214)
J Allergy Clin Immunol. 2003 May;111(5):1062-8. (PMID: 12743571)
Cancer Biother Radiopharm. 2006 Dec;21(6):553-60. (PMID: 17257070)
J Immunol. 2006 Nov 15;177(10):6667-74. (PMID: 17082579)
J Allergy Clin Immunol. 2006 Sep;118(3):749-55. (PMID: 16950297)
J Immunol. 2009 Apr 1;182(7):4036-45. (PMID: 19299701)
Front Oncol. 2016 Jan 07;5:300. (PMID: 26779443)
J Neurosci. 2007 Jul 11;27(28):7447-58. (PMID: 17626205)
Mol Immunol. 1997 Feb;34(3):227-35. (PMID: 9224965)
J Biol Chem. 2007 Dec 28;282(52):37669-77. (PMID: 17977829)
PLoS Negl Trop Dis. 2015 Aug 28;9(8):e0004032. (PMID: 26317855)
Adv Immunol. 2008;98:85-120. (PMID: 18772004)
Front Immunol. 2014 Nov 14;5:569. (PMID: 25452755)
J Oleo Sci. 2011;60(10):537-44. (PMID: 21937853)
J Biol Chem. 2004 Aug 27;279(35):36210-8. (PMID: 15229217)
Am J Pathol. 2016 Feb;186(2):212-24. (PMID: 26776074)
Cell Immunol. 1989 Apr 1;119(2):263-78. (PMID: 2784717)
Immunol Rev. 2007 Jun;217:168-85. (PMID: 17498059)
J Dermatol Sci. 2008 Jan;49(1):7-19. (PMID: 18024086)
Nat Rev Immunol. 2006 Mar;6(3):218-30. (PMID: 16470226)
J Biol Chem. 1994 Jul 29;269(30):19466-73. (PMID: 8034715)
J Biochem. 1998 Jul;124(1):194-9. (PMID: 9644263)
J Biol Chem. 1989 Aug 5;264(22):13267-72. (PMID: 2526814)
Front Immunol. 2014 Sep 22;5:453. (PMID: 25295038)
Immunol Rev. 2007 Jun;217:65-78. (PMID: 17498052)
Food Chem Toxicol. 2012 Dec;50(12 ):4382-8. (PMID: 22982805)
J Cell Biol. 1990 Aug;111(2):625-33. (PMID: 2166054)
J Biol Chem. 1997 Feb 7;272(6):3231-7. (PMID: 9013559)
Eur J Immunol. 1981 Apr;11(4):317-23. (PMID: 6166481)
Adv Exp Med Biol. 2002;507:41-6. (PMID: 12664562)
Immunobiology. 2006;211(10):815-20. (PMID: 17113919)
Biochim Biophys Acta. 2000 Oct 31;1488(1-2):124-38. (PMID: 11080682)
J Immunol. 1994 Jan 15;152(2):485-95. (PMID: 8283032)
J Cell Biol. 1992 Feb;116(3):635-46. (PMID: 1370498)
Exp Cell Res. 2008 Aug 1;314(13):2515-28. (PMID: 18585706)
المشرفين على المادة: 0 (Cytokines)
0 (Gangliosides)
0 (Interleukin-6)
0 (Leukotrienes)
0 (NF-kappa B)
0 (NFATC Transcription Factors)
0 (Prostaglandins D)
0 (Prostaglandins E)
0 (Tumor Necrosis Factor-alpha)
207137-56-2 (Interleukin-4)
EC 2.7.1.24 (Mitogen-Activated Protein Kinase 9)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
EC 2.7.11.24 (Mitogen-Activated Protein Kinase 8)
EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases)
EC 3.1.1.4 (Group IV Phospholipases A2)
تواريخ الأحداث: Date Created: 20160901 Date Completed: 20170515 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC4992799
DOI: 10.1155/2016/9160540
PMID: 27578923
قاعدة البيانات: MEDLINE
الوصف
تدمد:1466-1861
DOI:10.1155/2016/9160540