دورية أكاديمية
أعرض في EDS

Circulating interleukin-6 is not altered while γ-tocopherol is increased in subjects scheduled for knee surgery with low vitamin D.

التفاصيل البيبلوغرافية
العنوان: Circulating interleukin-6 is not altered while γ-tocopherol is increased in subjects scheduled for knee surgery with low vitamin D.
المؤلفون: Barker T; The Orthopedic Specialty Hospital, Murray, UT 84107, USA. Electronic address: tyler.barker@imail.org., Henriksen VT; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Rogers VE; The Orthopedic Specialty Hospital, Murray, UT 84107, USA., Momberger NG; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Rasmussen GL; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA., Trawick RH; The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.
المصدر: Cytokine [Cytokine] 2016 Dec; Vol. 88, pp. 108-114. Date of Electronic Publication: 2016 Sep 01.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0023 (Electronic) Linking ISSN: 10434666 NLM ISO Abbreviation: Cytokine Subsets: MEDLINE
أسماء مطبوعة: Publication: <2001- > : Oxford : Elsevier Science Ltd.
Original Publication: [Philadelphia, PA] : Saunders Scientific Publications, W.B. Saunders, [c1989-
مواضيع طبية MeSH: Interleukin-6/*blood , Knee Injuries/*blood , Knee Injuries/*surgery , Knee Joint/*surgery , Vitamin D Deficiency/*blood , gamma-Tocopherol/*blood, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Vitamin D Deficiency/surgery
مستخلص: The purpose of this study was to identify if circulating interleukin (IL)-6 and γ-tocopherol (γT) fluctuate with vitamin D status in subjects with an underlying knee joint injury or disease. We hypothesized that low vitamin D associates with an increase in plasma γT while serum IL-6 remains unchanged in subjects with an underlying knee joint trauma or disease. Fifty-four subjects scheduled to undergo primary, unilateral anterior cruciate ligament reconstructive surgery (ACL; n=27) or total knee arthroplasty (TKA; n=27) were studied. Circulating γT, α-tocopherol (αT), lipids (cholesterol and triglycerides), IL-6, and 25-hydroxyvitamin D (25(OH)D) were measured in fasting blood samples obtained prior to surgery. Subjects were classified as vitamin D deficient, insufficient, or sufficient if they had a serum 25(OH)D concentration <50, 50-75, or >75nM, respectively. The majority (57%) of the subjects possessed a serum 25(OH)D less than 50nM. Circulating cholesterol, triglycerides, and IL-6 were not significantly (all p>0.05) different between vitamin D status groups. However, lipid corrected αT was significantly (p<0.05) decreased and both lipid- and non-lipid-corrected plasma γT concentrations were significantly (both p<0.05) increased with low serum 25(OH)D (i.e., <50nM). A significant (p<0.05) multi-variate analysis revealed that an increase in plasma γT per lipids was significantly (p<0.05) predicted by a decrease in serum 25(OH)D but not by a decrease in plasma αT per lipids. We conclude that low vitamin D associates with an increase in plasma γT but not IL-6 in subjects with an underlying joint injury or disease.
(Copyright © 2016 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Interleukin-6; Orthopedics; Vitamin D; Vitamin E
المشرفين على المادة: 0 (IL6 protein, human)
0 (Interleukin-6)
8EF1Z1238F (gamma-Tocopherol)
تواريخ الأحداث: Date Created: 20160905 Date Completed: 20180104 Latest Revision: 20180210
رمز التحديث: 20221213
DOI: 10.1016/j.cyto.2016.08.025
PMID: 27591823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0023
DOI:10.1016/j.cyto.2016.08.025