دورية أكاديمية
Safety evaluation (acute and sub-acute studies) of the aqueous extract of the leaves of Myrianthus arboreus P. Beauv. (Cecropiaceae) in Wistar rats.
| العنوان: | Safety evaluation (acute and sub-acute studies) of the aqueous extract of the leaves of Myrianthus arboreus P. Beauv. (Cecropiaceae) in Wistar rats. |
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| المؤلفون: | Awounfack CF; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon., Ateba SB; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon., Zingue S; Laboratory of Physiology, Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon., Mouchili OR; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon., Njamen D; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: dnjamen@gmail.com. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2016 Dec 24; Vol. 194, pp. 169-178. Date of Electronic Publication: 2016 Aug 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Plant Extracts/*pharmacology , Plant Leaves/*chemistry , Urticaceae/*chemistry, Animals ; Body Weight/drug effects ; Dose-Response Relationship, Drug ; Female ; Male ; Organ Size/drug effects ; Plant Extracts/toxicity ; Rats ; Rats, Wistar ; Toxicity Tests, Acute ; Toxicity Tests, Subacute |
| مستخلص: | Ethnopharmacological Relevance: Myrianthus arboreus P. Beauv (Cecropiaceae) is a medicinal plant distributed in forests and damp places of tropical Africa. Its leaves are widely used as food and/or for the treatment of various ailments including dysmenorrhoea, female infertility, tumors and diarrhea. However, to the best of our knowledge, no safety assessment of this plant has been reported yet. Aim of Study: The present study aimed at evaluating the safety of the aqueous extract of leaves of Myrianthus arboreus (MAA) in Wistar rats through an acute and sub-acute oral administration. Material and Methods: In acute oral toxicity, the test was performed according to the Organization for Economic Cooperation and Development (OECD) guidelines Nr. 423 (acute toxicity class method, ATC) with slight modifications. Female Wistar rats were orally treated with the aqueous extract of M. arboreus at the doses of 2000 and 5000mg/kg. In sub-acute toxicity study, using the OECD guidelines Nr. 407, the extract was administered by gavage at the doses of 20, 110 and 200mg/kg/day for 28 consecutive days. Results: A single oral administration of 2000 or 5000mg/kg of the extract induced neither mortality nor exterior signs of toxicity indicating a LD Conclusion: The aqueous extract of Myrianthus arboreus leaves was non-toxic in acute administration and exhibited a relatively low toxicity potential on accessory sex organs in both sexes, and leukocytes in males following the repeated 28-days oral administration of the dose 200mg/kg. (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acute toxicity; Aqueous extract; Myrianthus arboreus; Sub-acute toxicity; Wistar rats |
| المشرفين على المادة: | 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20160905 Date Completed: 20170421 Latest Revision: 20220331 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.jep.2016.08.052 |
| PMID: | 27592311 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2016.08.052 |