دورية أكاديمية
Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study.
| العنوان: | Association of vitamin D levels and risk of ovarian cancer: a Mendelian randomization study. |
|---|---|
| المؤلفون: | Ong JS; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia., Cuellar-Partida G; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia., Lu Y; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Fasching PA; Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles.; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany., Hein A; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany., Burghaus S; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany., Beckmann MW; University Hospital Erlangen, Department of Gynecology and Obstetrics, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, Germany., Lambrechts D; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium.; Vesalius Research Center, VIB, Leuven, Belgium., Van Nieuwenhuysen E; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Vergote I; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Vanderstichele A; Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium., Anne Doherty J; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; School of Medicine, University of Queensland, St Lucia, QLD 4072, Australia., Anne Rossing M; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Chang-Claude J; German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany., Eilber U; German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany., Rudolph A; German Cancer Research Center, Division of Cancer Epidemiology, Heidelberg, Germany., Wang-Gohrke S; Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany., Goodman MT; Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.; Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Bogdanova N; Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Dürst M; Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany., Hillemanns P; Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany., Runnebaum IB; Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany., Antonenkova N; N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus., Butzow R; Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Leminen A; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Nevanlinna H; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Pelttari LM; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Edwards RP; Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA., Kelley JL; Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Modugno F, Moysich KB; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA., Ness RB; The University of Texas School of Public Health, Houston, TX, USA., Cannioto R; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA., Høgdall E; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark., Høgdall CK; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Jensen A; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark., Giles GG, Bruinsma F; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia., Kjaer SK; Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Hildebrandt MA; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang D; College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA., Lu KH; Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wu X; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bisogna M; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Dao F; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Levine DA; Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cramer DW; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA., Terry KL; Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA., Tworoger SS; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Stampfer M; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Missmer S, Bjorge L; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Salvesen HB; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Kopperud RK; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Bischof K; Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.; Centre for Cancer Biomarkers, Department of Clinical Science, University of Bergen, Bergen, Norway., Aben KK; Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands.; Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands., Kiemeney LA; Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands., Massuger LF; Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands., Brooks-Wilson A; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada., Olson SH; Memorial Sloan Kettering Cancer Center, Department of Epidemiology and Biostatistics, New York, NY, USA., McGuire V; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA., Rothstein JH; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA., Sieh W; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA., Whittemore AS; Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford CA, USA., Cook LS; Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA., Le ND; Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada., Gilks CB; Pathology and Laboratory Medicine, University of British Columbia, Vancouver BC, Canada., Gronwald J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Jakubowska A; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Lubiński J; International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland., Kluz T; Institute of Midwifery and Emergency Medicine, Clinic of Obstetrics and Gynecology, Frederick Chopin Clinical Provincial Hospital No 1, Faculty of Medicine, University of Rzeszów, Poland., Song H; The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Tyrer JP; The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Wentzensen N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Brinton L; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Trabert B; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Lissowska J; Department of Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland., McLaughlin JR; Public Health Ontario, Toronto, ON, Canada., Narod SA; Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada., Phelan C; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA., Anton-Culver H; Department of Epidemiology, University of California Irvine, Irvine, CA, USA.; Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA., Ziogas A; Department of Epidemiology, University of California Irvine, Irvine, CA, USA., Eccles D; Faculty of Medicine, University of Southampton, Southampton, UK., Campbell I; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Australia., Gayther SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA., Gentry-Maharaj A; Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom., Menon U; Women's Cancer, Institute for Women's Health, University College London, London, United Kingdom., Ramus SJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA., Wu AH; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA., Dansonka-Mieszkowska A; Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Kupryjanczyk J; Department of Obstetrics, Gynaecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland., Timorek A; Department of Obstetrics, Gynaecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland., Szafron L; Department of Pathology and Laboratory Diagnostics, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland., Cunningham JM; Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA., Fridley BL; Department of Biostatistics, University of Kansas, Kansas City, KS, USA., Winham SJ; Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Bandera EV; Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Poole EM; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Morgan TK; Departments of Pathology and Obstetrics & Gynaecology, OHSU, Portland, OR, USA., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA., Goode EL; Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA., Schildkraut JM; Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA.; Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA., Pearce CL; Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Berchuck A; Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA and., Pharoah PD; The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Chenevix-Trench G; Cancer Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Gharahkhani P; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Neale RE; Gynaecological Cancers laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.; Cancer Aetiology and Prevention laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., Webb PM; Gynaecological Cancers laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia., MacGregor S; Statistical Genetics laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia, stuart.macgregor@qimrberghofer.edu.au. |
| مؤلفون مشاركون: | Australian Ovarian Cancer Study |
| المصدر: | International journal of epidemiology [Int J Epidemiol] 2016 Oct; Vol. 45 (5), pp. 1619-1630. Date of Electronic Publication: 2016 Sep 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7802871 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3685 (Electronic) Linking ISSN: 03005771 NLM ISO Abbreviation: Int J Epidemiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] Oxford University Press. |
| مواضيع طبية MeSH: | Mendelian Randomization Analysis* , Polymorphism, Single Nucleotide*, Neoplasms, Glandular and Epithelial/*blood , Neoplasms, Glandular and Epithelial/*epidemiology , Ovarian Neoplasms/*blood , Ovarian Neoplasms/*epidemiology , Vitamin D/*analogs & derivatives, Carcinoma, Ovarian Epithelial ; Female ; Genetic Predisposition to Disease ; Humans ; Neoplasms, Glandular and Epithelial/genetics ; Odds Ratio ; Ovarian Neoplasms/genetics ; Risk Factors ; Vitamin D/blood |
| مستخلص: | Background: In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between vitamin D and ovarian cancer is uncertain, with observational studies generating conflicting findings. A potential limitation of observational studies is inadequate control of confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate the association between single nucleotide polymorphisms (SNPs) associated with circulating 25-hydroxyvitamin D [25(OH)D] concentration and risk of ovarian cancer. Methods: We employed SNPs with well-established associations with 25(OH)D concentration as instrumental variables for MR: rs7944926 (DHCR7), rs12794714 (CYP2R1) and rs2282679 (GC). We included 31 719 women of European ancestry (10 065 cases, 21 654 controls) from the Ovarian Cancer Association Consortium, who were genotyped using customized Illumina Infinium iSelect (iCOGS) arrays. A two-sample (summary data) MR approach was used and analyses were performed separately for all ovarian cancer (10 065 cases) and for high-grade serous ovarian cancer (4121 cases). Results: The odds ratio for epithelial ovarian cancer risk (10 065 cases) estimated by combining the individual SNP associations using inverse variance weighting was 1.27 (95% confidence interval: 1.06 to 1.51) per 20 nmol/L decrease in 25(OH)D concentration. The estimated odds ratio for high-grade serous epithelial ovarian cancer (4121 cases) was 1.54 (1.19, 2.01). Conclusions: Genetically lowered 25-hydroxyvitamin D concentrations were associated with higher ovarian cancer susceptibility in Europeans. These findings suggest that increasing plasma vitamin D levels may reduce risk of ovarian cancer. (© The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.) |
| التعليقات: | Comment in: Int J Epidemiol. 2016 Oct;45(5):1631-1633. (PMID: 27892412) |
| References: | Int J Cancer. 2015 Mar 1;136(5):E359-86. (PMID: 25220842) Front Oncol. 2014 Oct 20;4:286. (PMID: 25368842) PLoS Med. 2008 Aug 26;5(8):e177. (PMID: 18752343) Hum Mol Genet. 2015 Oct 15;24(20):5955-64. (PMID: 26231222) Lancet Diabetes Endocrinol. 2014 Apr;2(4):298-306. (PMID: 24703048) Endocrinol Metab Clin North Am. 2010 Jun;39(2):333-46, table of contents. (PMID: 20511055) Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):783-8. (PMID: 17416771) PLoS One. 2012;7(6):e37662. (PMID: 22701574) Nat Biotechnol. 2010 Dec;28(12):1248-50. (PMID: 21139605) BMJ. 2014 Nov 18;349:g6330. (PMID: 25406188) Nat Genet. 2007 Jul;39(7):906-13. (PMID: 17572673) Eur J Epidemiol. 2015 Jul;30(7):543-52. (PMID: 25773750) Clin Chem. 2013 May;59(5):793-7. (PMID: 23319826) Ginekol Pol. 2013 Apr;84(4):305-8. (PMID: 23700865) Curr Med Res Opin. 2008 Jan;24(1):139-49. (PMID: 18034918) Annu Rev Pharmacol Toxicol. 2011;51:311-36. (PMID: 20936945) PLoS Med. 2015 Aug 25;12(8):e1001866. (PMID: 26305103) Nat Genet. 2013 Apr;45(4):362-70, 370e1-2. (PMID: 23535730) Am J Obstet Gynecol. 2010 Jul;203(1):70.e1-8. (PMID: 20227054) J Oncol. 2009;2009:672492. (PMID: 19727412) Am J Clin Nutr. 2015 Jul;102(1):109-14. (PMID: 25971716) Am J Epidemiol. 2010 Jul 1;172(1):70-80. (PMID: 20562186) J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):301-21. (PMID: 18368558) Hum Mol Genet. 2010 Jul 1;19(13):2739-45. (PMID: 20418485) PLoS One. 2012;7(5):e37465. (PMID: 22629401) Gynecol Oncol. 2011 May 1;121(2):369-75. (PMID: 21324518) Proc Natl Acad Sci U S A. 2004 May 18;101(20):7711-5. (PMID: 15128933) Clin Exp Immunol. 2014 Jul;177(1):366-72. (PMID: 24730464) Anticancer Agents Med Chem. 2013 Jan;13(1):70-82. (PMID: 23094923) Gynecol Oncol. 2010 Nov;119(2):314-8. (PMID: 20684976) N Engl J Med. 2013 Nov 21;369(21):1991-2000. (PMID: 24256378) Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10 ):1990-9. (PMID: 17932346) Eur J Cancer. 2010 Jan;46(2):364-9. (PMID: 19713101) CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90. (PMID: 21296855) Genet Epidemiol. 2013 Nov;37(7):658-65. (PMID: 24114802) Stat Methods Med Res. 2015 Aug 17;:null. (PMID: 26282889) Cancers (Basel). 2013 Nov 22;5(4):1577-600. (PMID: 24351671) Biochem J. 2012 Jan 1;441(1):61-76. (PMID: 22168439) Lancet. 2010 Jul 17;376(9736):180-8. (PMID: 20541252) Sci Rep. 2016 May 24;6:26496. (PMID: 27215954) Int J Epidemiol. 2015 Apr;44(2):512-25. (PMID: 26050253) Gynecol Oncol. 2014 May;133(2):147-54. (PMID: 24556058) Rocz Panstw Zakl Hig. 2014;65(4):273-9. (PMID: 25526571) |
| معلومات مُعتمدة: | P01 CA017054 United States CA NCI NIH HHS; P50 CA159981 United States CA NCI NIH HHS; N01 PC067010 United States PC NCI NIH HHS; R01 CA122443 United States CA NCI NIH HHS; United Kingdom DH_ Department of Health; P30 CA076292 United States CA NCI NIH HHS; R01 CA067262 United States CA NCI NIH HHS; K22 CA138563 United States CA NCI NIH HHS; R03 CA115195 United States CA NCI NIH HHS; C490/A6187 United Kingdom CRUK_ Cancer Research UK; 10119 United Kingdom CRUK_ Cancer Research UK; R01 CA063682 United States CA NCI NIH HHS; 10124 United Kingdom CRUK_ Cancer Research UK; P30 CA016672 United States CA NCI NIH HHS; R01 CA049449 United States CA NCI NIH HHS; R01 CA083918 United States CA NCI NIH HHS; U01 CA069417 United States CA NCI NIH HHS; U19 CA148112 United States CA NCI NIH HHS; N01 PC035137 United States PC NCI NIH HHS; R01 CA058860 United States CA NCI NIH HHS; P01 CA087969 United States CA NCI NIH HHS; K07 CA143047 United States CA NCI NIH HHS; P50 CA105009 United States CA NCI NIH HHS; P30 CA046592 United States CA NCI NIH HHS; R01 CA095023 United States CA NCI NIH HHS; R01 CA136924 United States CA NCI NIH HHS; R01 CA126841 United States CA NCI NIH HHS; K07 CA095666 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; R01 CA054419 United States CA NCI NIH HHS; R01 CA112523 United States CA NCI NIH HHS; P30 CA072720 United States CA NCI NIH HHS; R01 CA114343 United States CA NCI NIH HHS; R01 CA063678 United States CA NCI NIH HHS; 16561 United Kingdom CRUK_ Cancer Research UK; UM1 CA176726 United States CA NCI NIH HHS; UM1 CA186107 United States CA NCI NIH HHS; R01 CA074850 United States CA NCI NIH HHS; R01 CA058598 United States CA NCI NIH HHS; R01 CA050385 United States CA NCI NIH HHS; P50 CA136393 United States CA NCI NIH HHS; R01 CA087538 United States CA NCI NIH HHS; R03 CA113148 United States CA NCI NIH HHS; R01 CA149429 United States CA NCI NIH HHS |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) A288AR3C9H (25-hydroxyvitamin D) |
| تواريخ الأحداث: | Date Created: 20160906 Date Completed: 20180205 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC5100621 |
| DOI: | 10.1093/ije/dyw207 |
| PMID: | 27594614 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3685 |
|---|---|
| DOI: | 10.1093/ije/dyw207 |