التفاصيل البيبلوغرافية
| العنوان: |
Endomyocardial biopsy pathology in insulin-dependent diabetic patients with abnormal ventricular function. |
| المؤلفون: |
Sutherland CG; Department of Pathology, Royal Infirmary, Glasgow, Scotland., Fisher BM, Frier BM, Dargie HJ, More IA, Lindop GB |
| المصدر: |
Histopathology [Histopathology] 1989 Jun; Vol. 14 (6), pp. 593-602. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 7704136 Publication Model: Print Cited Medium: Print ISSN: 0309-0167 (Print) Linking ISSN: 03090167 NLM ISO Abbreviation: Histopathology Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: |
Coronary Vessels/*ultrastructure , Diabetes Mellitus, Type 1/*pathology , Heart Ventricles/*physiopathology, Adult ; Biopsy ; Diabetes Mellitus, Type 1/physiopathology ; Heart Ventricles/pathology ; Humans ; Microscopy, Electron ; Middle Aged |
| مستخلص: |
We have previously shown impaired ventricular function in asymptomatic middle-aged type 1 (insulin-dependent) diabetic patients who had no evidence of coronary artery disease. The diabetic patients had normal coronary angiograms but reduced ventricular ejection fraction on exercise. To examine the possible contribution of small vessel disease to this functional abnormality, we compared endomyocardial biopsies from seven symptom-free type 1 diabetic patients with biopsies from seven age- and sex-matched non-diabetic subjects. Interstitial fibrosis was present in three diabetic patients, arteriolar hyalinization in three patients and arteriolar thickening was observed in five patients. Morphometry performed on electron micrographs showed no significant difference in the thickness of the capillary basal lamina between diabetics and controls. While the functional significance of the abnormalities on light microscopy is unclear, our findings indicate that the abnormality of cardiac function described in diabetes is not associated with thickening of the myocardial capillary basal lamina. |
| تواريخ الأحداث: |
Date Created: 19890601 Date Completed: 19890908 Latest Revision: 20190820 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1111/j.1365-2559.1989.tb02200.x |
| PMID: |
2759556 |
| قاعدة البيانات: |
MEDLINE |
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