دورية أكاديمية
أعرض في EDS

Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure.

التفاصيل البيبلوغرافية
العنوان: Salivary Biomarkers, Oral Inflammation, and Functional Status in Patients With Heart Failure.
المؤلفون: Dekker RL; 1 University of Kentucky College of Nursing, Lexington, KY, USA., Lennie TA; 1 University of Kentucky College of Nursing, Lexington, KY, USA., Moser DK; 1 University of Kentucky College of Nursing, Lexington, KY, USA., Miller CS; 2 University of Kentucky College of Dentistry, Lexington, KY, USA., Ebersole JL; 2 University of Kentucky College of Dentistry, Lexington, KY, USA., Chung ML; 1 University of Kentucky College of Nursing, Lexington, KY, USA., Campbell CL; 3 University of Tennessee/Erlanger Health Systems in Chattanooga Division of Cardiology, Chattanooga, TN, USA., Bailey A; 3 University of Tennessee/Erlanger Health Systems in Chattanooga Division of Cardiology, Chattanooga, TN, USA., Tovar EG; 1 University of Kentucky College of Nursing, Lexington, KY, USA.
المصدر: Biological research for nursing [Biol Res Nurs] 2017 Mar; Vol. 19 (2), pp. 153-161. Date of Electronic Publication: 2016 Sep 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications, Inc Country of Publication: United States NLM ID: 9815758 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4175 (Electronic) Linking ISSN: 10998004 NLM ISO Abbreviation: Biol Res Nurs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Thousand Oaks, CA : Sage Publications, Inc., c1999-
مواضيع طبية MeSH: Biomarkers/*analysis , Heart Failure/*physiopathology , Inflammation/*chemically induced , Saliva/*chemistry, Adult ; Aged ; Female ; Humans ; Interleukin-10/blood ; Interleukin-6/blood ; Kentucky ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Salivary Proteins and Peptides/analysis
مستخلص: Aims: To describe correlations and agreement between salivary and serum B-type natriuretic peptide (BNP), C-reactive protein (CRP), interleukin (IL)-6, and IL-10 and determine which biomarkers predict worse functional class in patients with heart failure (HF).
Methods: Serum and saliva were collected from 75 hospitalized patients with HF (57 ± 12 years, 43% female, New York Heart Association [NYHA] Classes I [4%], II [43%], and III [53%]). Oral inflammation was rated as good, fair, or poor. Spearman's ρ and Bland-Altman were used to determine correlations and agreement of the salivary and serum forms of each biomarker. Logistic regressions were used to determine which biomarkers predicted worse NYHA functional class, controlling for depression, body mass index, smoking, and oral inflammation.
Results: Median biomarker concentrations were as follows: BNP (serum 361 pg/ml, saliva 9 pg/ml), CRP (serum 13 ng/ml, saliva 25.6 ng/ml), IL-6 (serum 19.3 pg/ml, saliva 10.5 pg/ml), and IL-10 (serum 64.1 pg/ml, saliva 4.7 pg/ml). There was a moderate-to-strong correlation for serum-salivary CRP, weak correlation for serum-salivary IL-6, and no correlations for serum-salivary BNP and IL-10. The Bland-Altman test showed good salivary-serum agreement for all biomarkers, but as serum concentrations rose, salivary measures underestimated serum levels. Visible oral inflammation was the only predictor of worse NYHA class.
References: Am J Cardiol. 2010 Sep 15;106(6):830-5. (PMID: 20816124)
Biomark Med. 2010 Feb;4(1):171-89. (PMID: 20387312)
PLoS One. 2012;7(10):e48452. (PMID: 23119023)
Clin Transl Med. 2012 Sep 05;1(1):19. (PMID: 23369566)
Am J Cardiol. 2008 Feb 1;101(3):370-3. (PMID: 18237602)
Lab Chip. 2005 Mar;5(3):261-9. (PMID: 15726202)
Ann N Y Acad Sci. 1993 Sep 20;694:72-7. (PMID: 8215087)
Gen Hosp Psychiatry. 2005 Sep-Oct;27(5):338-43. (PMID: 16168794)
J Periodontol. 2010 Jun;81(6):870-6. (PMID: 20350152)
J Int Oral Health. 2014 Jul;6(4):95-103. (PMID: 25214743)
Oral Dis. 2011 Sep;17(6):597-600. (PMID: 21635668)
Int J Crit Illn Inj Sci. 2014 Jul;4(3):209-15. (PMID: 25337482)
Lancet. 1986 Feb 8;1(8476):307-10. (PMID: 2868172)
Heart Fail Rev. 2010 Jul;15(4):331-41. (PMID: 19363700)
BMJ. 1989 Mar 25;298(6676):779-81. (PMID: 2496855)
Periodontol 2000. 2016 Feb;70(1):164-83. (PMID: 26662489)
Stat Methods Med Res. 1999 Jun;8(2):135-60. (PMID: 10501650)
Clin Chem. 2011 May;57(5):675-87. (PMID: 21383043)
J Clin Periodontol. 2004 Jul;31(7):574-80. (PMID: 15191595)
Med Care. 1996 Jan;34(1):73-84. (PMID: 8551813)
J Dent Res. 2014 Jul;93(7 Suppl):72S-79S. (PMID: 24879575)
J Chronic Dis. 1987;40(5):373-83. (PMID: 3558716)
Jpn Circ J. 1999 Dec;63(12):951-6. (PMID: 10614840)
J Periodontol. 2014 Jun;85(6):761-4. (PMID: 24875011)
BMJ. 1993 Mar 13;306(6879):688-91. (PMID: 8471920)
Thromb Res. 1994 Sep 1;75(5):503-11. (PMID: 7992251)
Br Dent J. 2003 Feb 22;194(4):215-8; discussion 205. (PMID: 12627201)
Heart Vessels. 2009 Jul;24(4):271-6. (PMID: 19626399)
J Immunol Methods. 2011 Oct 28;373(1-2):19-25. (PMID: 21821037)
Clin Cardiol. 1996 Jun;19(6):455-60. (PMID: 8790948)
J Periodontol. 1996 Oct;67(10 Suppl):1123-37. (PMID: 8910831)
J Gen Intern Med. 2001 Sep;16(9):606-13. (PMID: 11556941)
معلومات مُعتمدة: K23 NR013480 United States NR NINR NIH HHS; P20 NR010679 United States NR NINR NIH HHS; P30 GM110788 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: B-type natriuretic peptide; cytokines; inflammatory biomarkers; periodontal disease
المشرفين على المادة: 0 (Biomarkers)
0 (Interleukin-6)
0 (Salivary Proteins and Peptides)
114471-18-0 (Natriuretic Peptide, Brain)
130068-27-8 (Interleukin-10)
تواريخ الأحداث: Date Created: 20160909 Date Completed: 20170606 Latest Revision: 20231112
رمز التحديث: 20231112
مُعرف محوري في PubMed: PMC5942485
DOI: 10.1177/1099800416665197
PMID: 27605566
قاعدة البيانات: MEDLINE
الوصف
تدمد:1552-4175
DOI:10.1177/1099800416665197