دورية أكاديمية
أعرض في EDS

When β-cells fail: lessons from dedifferentiation.

التفاصيل البيبلوغرافية
العنوان: When β-cells fail: lessons from dedifferentiation.
المؤلفون: Accili D; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York. da230@cumc.columbia.edu., Talchai SC; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Kim-Muller JY; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Cinti F; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Ishida E; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Ordelheide AM; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Kuo T; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Fan J; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York., Son J; Department of Medicine and Berrie Diabetes Center, Columbia University, New York, New York.
المصدر: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2016 Sep; Vol. 18 Suppl 1, pp. 117-22.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 100883645 Publication Model: Print Cited Medium: Internet ISSN: 1463-1326 (Electronic) Linking ISSN: 14628902 NLM ISO Abbreviation: Diabetes Obes Metab Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell, c1999-
مواضيع طبية MeSH: Cell Dedifferentiation*, Diabetes Mellitus, Type 2/*metabolism , Forkhead Transcription Factors/*metabolism , Insulin/*metabolism , Insulin-Secreting Cells/*cytology, Animals ; Humans ; Insulin Secretion ; Insulin-Secreting Cells/metabolism ; Mice
مستخلص: Diabetes is caused by a combination of impaired responsiveness to insulin and reduced production of insulin by the pancreas. Until recently, the decline of insulin production had been ascribed to β-cell death. But recent research has shown that β-cells do not die in diabetes, but undergo a silencing process, termed "dedifferentiation." The main implication of this discovery is that β-cells can be revived by appropriate treatments. We have shown that mitochondrial abnormalities are a key step in the progression of β-cell dysfunction towards dedifferentiation. In normal β-cells, mitochondria generate energy required to sustain insulin production and its finely timed release in response to the body's nutritional status. A normal β-cell can adapt its mitochondrial fuel source based on substrate availability, a concept known as "metabolic flexibility." This capability is the first casualty in the progress of β-cell failure. β-Cells lose the ability to select the right fuel for mitochondrial energy production. Mitochondria become overloaded, and accumulate by-products derived from incomplete fuel utilization. Energy production stalls, and insulin production drops, setting the stage for dedifferentiation. The ultimate goal of these investigations is to explore novel treatment paradigms that will benefit people with diabetes.
Competing Interests: statement The authors declare that they have no conflict, financial or otherwise, with the content of this article.
(© 2016 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: P30 DK026687 United States DK NIDDK NIH HHS; P30 DK063608 United States DK NIDDK NIH HHS; R01 DK057539 United States DK NIDDK NIH HHS; R01 DK064819 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: aldehyde dehydrogenase; biomarker; genetics; human disease; lineage marker; progenitor cells; regeneration; therapeutic failure
المشرفين على المادة: 0 (Forkhead Transcription Factors)
0 (Insulin)
تواريخ الأحداث: Date Created: 20160913 Date Completed: 20171031 Latest Revision: 20220312
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5021187
DOI: 10.1111/dom.12723
PMID: 27615140
قاعدة البيانات: MEDLINE
الوصف
تدمد:1463-1326
DOI:10.1111/dom.12723