دورية أكاديمية
Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis.
| العنوان: | Computer-Aided Drug Discovery Approaches against the Tropical Infectious Diseases Malaria, Tuberculosis, Trypanosomiasis, and Leishmaniasis. |
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| المؤلفون: | Njogu PM; Department of Pharmaceutical Chemistry and ‡Division of Pharmacology, School of Pharmacy, University of Nairobi , P.O. Box 19676-00202, Nairobi, Kenya.; Department of Chemistry, ⊗Institute of Infectious Disease and Molecular Medicine, and ΘSouth African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town , Rondebosch 7701, South Africa., Guantai EM; Department of Pharmaceutical Chemistry and ‡Division of Pharmacology, School of Pharmacy, University of Nairobi , P.O. Box 19676-00202, Nairobi, Kenya.; Department of Chemistry, ⊗Institute of Infectious Disease and Molecular Medicine, and ΘSouth African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town , Rondebosch 7701, South Africa., Pavadai E; Department of Pharmaceutical Chemistry and ‡Division of Pharmacology, School of Pharmacy, University of Nairobi , P.O. Box 19676-00202, Nairobi, Kenya.; Department of Chemistry, ⊗Institute of Infectious Disease and Molecular Medicine, and ΘSouth African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town , Rondebosch 7701, South Africa., Chibale K; Department of Pharmaceutical Chemistry and ‡Division of Pharmacology, School of Pharmacy, University of Nairobi , P.O. Box 19676-00202, Nairobi, Kenya.; Department of Chemistry, ⊗Institute of Infectious Disease and Molecular Medicine, and ΘSouth African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town , Rondebosch 7701, South Africa. |
| المصدر: | ACS infectious diseases [ACS Infect Dis] 2016 Jan 08; Vol. 2 (1), pp. 8-31. Date of Electronic Publication: 2015 Nov 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : ACS Publications, [2015]- |
| مواضيع طبية MeSH: | Drug Design*, Computer-Aided Design/*trends , Leishmaniasis/*drug therapy , Malaria/*drug therapy , Molecular Targeted Therapy/*trends , Trypanosomiasis/*drug therapy , Tuberculosis/*drug therapy, Antimalarials/chemistry ; Antiprotozoal Agents/chemistry ; Antitubercular Agents/chemistry ; Global Health ; Humans ; Program Development ; Structure-Activity Relationship |
| مستخلص: | Despite the tremendous improvement in overall global health heralded by the adoption of the Millennium Declaration in the year 2000, tropical infections remain a major health problem in the developing world. Recent estimates indicate that the major tropical infectious diseases, namely, malaria, tuberculosis, trypanosomiasis, and leishmaniasis, account for more than 2.2 million deaths and a loss of approximately 85 million disability-adjusted life years annually. The crucial role of chemotherapy in curtailing the deleterious health and economic impacts of these infections has invigorated the search for new drugs against tropical infectious diseases. The research efforts have involved increased application of computational technologies in mainstream drug discovery programs at the hit identification, hit-to-lead, and lead optimization stages. This review highlights various computer-aided drug discovery approaches that have been utilized in efforts to identify novel antimalarial, antitubercular, antitrypanosomal, and antileishmanial agents. The focus is largely on developments over the past 5 years (2010-2014). |
| فهرسة مساهمة: | Keywords: computer-aided drug discovery; leishmaniasis; malaria; tropical infections; trypanosomiasis; tuberculosis |
| المشرفين على المادة: | 0 (Antimalarials) 0 (Antiprotozoal Agents) 0 (Antitubercular Agents) |
| تواريخ الأحداث: | Date Created: 20160914 Date Completed: 20180131 Latest Revision: 20180131 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/acsinfecdis.5b00093 |
| PMID: | 27622945 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 2373-8227 |
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| DOI: | 10.1021/acsinfecdis.5b00093 |