دورية أكاديمية
Rho GTPases: Regulation and roles in cancer cell biology.
العنوان: | Rho GTPases: Regulation and roles in cancer cell biology. |
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المؤلفون: | Haga RB; a Randall Division of Cell and Molecular Biophysics, King's College London , London , UK., Ridley AJ; a Randall Division of Cell and Molecular Biophysics, King's College London , London , UK. |
المصدر: | Small GTPases [Small GTPases] 2016 Oct; Vol. 7 (4), pp. 207-221. Date of Electronic Publication: 2016 Sep 14. |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101530974 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2154-1256 (Electronic) Linking ISSN: 21541248 NLM ISO Abbreviation: Small GTPases Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Austin, TX : Landes Bioscience |
مواضيع طبية MeSH: | Neoplasms/*metabolism , rho GTP-Binding Proteins/*genetics , rho GTP-Binding Proteins/*metabolism, Amino Acid Substitution ; Animals ; Cell Movement ; Disease Progression ; Humans ; Neoplasms/genetics ; Signal Transduction |
مستخلص: | Rho GTPases are well known for their roles in regulating cell migration, and also contribute to a variety of other cellular responses. They are subdivided into 2 groups: typical and atypical. The typical Rho family members, including RhoA, Rac1 and Cdc42, cycle between an active GTP-bound and inactive GDP-bound conformation, and are regulated by GEFs, GAPs and GDIs, whereas atypical Rho family members have amino acid substitutions that alter their ability to interact with GTP/GDP and hence are regulated by different mechanisms. Both typical and atypical Rho GTPases contribute to cancer progression. In a few cancers, RhoA or Rac1 are mutated, but in most cancers expression levels and/or activity of Rho GTPases is altered. Rho GTPase signaling could therefore be therapeutically targeted in cancer treatment. |
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معلومات مُعتمدة: | 15961 United Kingdom CRUK_ Cancer Research UK |
فهرسة مساهمة: | Keywords: Rho GTPases; cancer progression; cell migration; signal transduction |
المشرفين على المادة: | EC 3.6.5.2 (rho GTP-Binding Proteins) |
تواريخ الأحداث: | Date Created: 20160916 Date Completed: 20171016 Latest Revision: 20240210 |
رمز التحديث: | 20240210 |
مُعرف محوري في PubMed: | PMC5129894 |
DOI: | 10.1080/21541248.2016.1232583 |
PMID: | 27628050 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2154-1256 |
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DOI: | 10.1080/21541248.2016.1232583 |