دورية أكاديمية
أعرض في EDS

Beta-cyclodextrin enhanced gastroprotective effect of (-)-linalool, a monoterpene present in rosewood essential oil, in gastric lesion models.

التفاصيل البيبلوغرافية
العنوان: Beta-cyclodextrin enhanced gastroprotective effect of (-)-linalool, a monoterpene present in rosewood essential oil, in gastric lesion models.
المؤلفون: da Silva FV; Postgraduate Program in Biotechnology - RENORBIO, Focal Point - Federal University of Piauí, Teresina, Piauí, Brazil., de Barros Fernandes H; Postgraduate Program in Biotechnology - RENORBIO, Focal Point - Federal University of Piauí, Teresina, Piauí, Brazil., Oliveira IS; Postgraduate Program in Biotechnology - RENORBIO, Focal Point - Federal University of Piauí, Teresina, Piauí, Brazil., Viana AF; Postgraduate Program in Pharmacology, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil., da Costa DS; Postgraduate Program in Biotechnology - RENORBIO, Focal Point - Federal University of Piauí, Teresina, Piauí, Brazil., Lopes MT; Laboratory of Tumoral Cell, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., de Lira KL; Medicinal Plants Research Center, Health Sciences Center, Federal University of Piauí, Av. Nossa Senhora de Fátima s/n, Teresina, Piauí, 64049-550, Brazil., Quintans-Júnior LJ; Department of Physiology, Federal University of Sergipe, Aracaju, Sergipe, Brazil., de Sousa AA; Department of Pharmacia, Federal University of Sergipe, Aracaju, Sergipe, Brazil., de Cássia Meneses Oliveira R; Postgraduate Program in Biotechnology - RENORBIO, Focal Point - Federal University of Piauí, Teresina, Piauí, Brazil. menesesoliveira@gmail.com.; Medicinal Plants Research Center, Health Sciences Center, Federal University of Piauí, Av. Nossa Senhora de Fátima s/n, Teresina, Piauí, 64049-550, Brazil. menesesoliveira@gmail.com.
المصدر: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2016 Nov; Vol. 389 (11), pp. 1245-1251. Date of Electronic Publication: 2016 Sep 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer Verlag.
مواضيع طبية MeSH: Magnoliopsida*/chemistry, Anti-Ulcer Agents/*pharmacology , Monoterpenes/*pharmacology , Oils, Volatile/*pharmacology , Plant Oils/*pharmacology , Stomach/*drug effects , Stomach Ulcer/*prevention & control , beta-Cyclodextrins/*pharmacology, Acetic Acid ; Acyclic Monoterpenes ; Animals ; Anti-Ulcer Agents/chemistry ; Anti-Ulcer Agents/isolation & purification ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Cytoprotection ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Stability ; Drug Therapy, Combination ; Ethanol ; Female ; Gastric Mucosa/metabolism ; Lipid Peroxidation/drug effects ; Male ; Mice ; Monoterpenes/chemistry ; Monoterpenes/isolation & purification ; Oils, Volatile/isolation & purification ; Peroxidase/metabolism ; Phytotherapy ; Plant Oils/isolation & purification ; Plants, Medicinal ; Rats, Wistar ; Solubility ; Stomach/pathology ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; Stomach Ulcer/pathology ; Sulfhydryl Compounds/metabolism
مستخلص: (-)-Linalool is a monoterpene constituent of many essential oils. This particular monoterpene has both anti-inflammatory and antimicrobial activity. Moreover, this compound has been shown to be antinociceptive. However, the poor chemical stability and short half-life prevents the clinical application of (-)-linalool and many other essential oils. Important to the topic of this study, β-cyclodextrin (β-CD) has been used to increase the solubility, stability, and pharmacological effects of numerous lipophilic compounds in vivo. In this study, the gastroprotective activities of (-)-linalool (LIN) and linalool incorporated into inclusion complex containing β-cyclodextrin (LIN-βCD) were evaluated using models of acute and chronic gastric ulcers in rodents. LIN and LIN-βCD showed strong gastroprotective activity (p < 0.001). The LIN-βCD complex revealed that the gastroprotective effect was significantly improved compared with LIN uncomplexed, suggesting that this improvement is related to increased solubility and stability. Taking together the potentiation of the antioxidant profile of this monoterpene, our results suggest that β-CD may represent an important tool for improved gastroprotective activity of (-)-linalool and other water-insoluble compounds.
References: Expert Opin Ther Pat. 2015;25(8):897-907. (PMID: 25960079)
Phytomedicine. 2013 Mar 15;20(5):436-40. (PMID: 23357360)
Expert Opin Drug Deliv. 2015;12(9):1425-41. (PMID: 26098975)
Phytomedicine. 2002 Dec;9(8):721-6. (PMID: 12587692)
Molecules. 2009 Mar 03;14(3):979-1012. (PMID: 19305355)
J Pain. 2010 Nov;11(11):1222-9. (PMID: 20452289)
Gastroenterology. 1979 Sep;77(3):433-43. (PMID: 456839)
Blood. 1982 Sep;60(3):618-22. (PMID: 6286012)
Gastroenterology. 1984 Dec;87(6):1344-50. (PMID: 6092199)
Phytother Res. 2012 Jan;26(1):73-7. (PMID: 21544884)
Anal Biochem. 1978 May;86(1):271-8. (PMID: 655387)
Anal Biochem. 1968 Oct 24;25(1):192-205. (PMID: 4973948)
Mol Microbiol. 2001 Sep;41(5):1037-51. (PMID: 11555285)
Eur J Pharmacol. 2004 Aug 30;497(3):279-84. (PMID: 15336945)
Microsc Res Tech. 2001 Jun 15;53(6):396-408. (PMID: 11525257)
Am J Dig Dis. 1972 Jul;17(7):619-29. (PMID: 5032686)
Int Rev Neurobiol. 2009;85:221-35. (PMID: 19607973)
Arthritis Res Ther. 2007;9(3):R52. (PMID: 17521422)
Chem Biol Interact. 2015 Feb 5;227:69-76. (PMID: 25557507)
Expert Opin Drug Deliv. 2015;12(10):1677-88. (PMID: 26159048)
Expert Opin Drug Deliv. 2005 Mar;2(2):335-51. (PMID: 16296758)
Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):167-72. (PMID: 23692366)
Eur J Pharmacol. 2003 Jan 26;460(1):37-41. (PMID: 12535857)
J Ethnopharmacol. 2010 Jul 6;130(1):85-92. (PMID: 20420892)
Toxicol Appl Pharmacol. 2013 Oct 1;272(1):21-9. (PMID: 23769714)
Scand J Gastroenterol Suppl. 1995;210:9-14. (PMID: 8578218)
Microb Pathog. 2001 Jul;31(1):29-36. (PMID: 11427034)
Food Chem Toxicol. 2008 Feb;46(2):446-75. (PMID: 17996351)
Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):935-42. (PMID: 24958161)
Eur J Pharmacol. 1973 May;22(2):191-5. (PMID: 4514976)
Life Sci. 2006 Apr 18;78(21):2471-4. (PMID: 16343551)
J Ethnopharmacol. 2013 Jun 21;148(1):175-81. (PMID: 23608239)
فهرسة مساهمة: Keywords: Acetic acid; Ethanol; Gastric damage; Linalool; β-cyclodextrin
المشرفين على المادة: 0 (Acyclic Monoterpenes)
0 (Anti-Ulcer Agents)
0 (Antioxidants)
0 (Monoterpenes)
0 (Oils, Volatile)
0 (Plant Oils)
0 (Sulfhydryl Compounds)
0 (beta-Cyclodextrins)
3K9958V90M (Ethanol)
D81QY6I88E (linalool)
EC 1.11.1.7 (Peroxidase)
Q40Q9N063P (Acetic Acid)
تواريخ الأحداث: Date Created: 20160916 Date Completed: 20170221 Latest Revision: 20191210
رمز التحديث: 20231215
DOI: 10.1007/s00210-016-1298-3
PMID: 27629579
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1912
DOI:10.1007/s00210-016-1298-3