دورية أكاديمية
A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease.
| العنوان: | A Tol2 Gateway-Compatible Toolbox for the Study of the Nervous System and Neurodegenerative Disease. |
|---|---|
| المؤلفون: | Don EK; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Formella I; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Badrock AP; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Hall TE; 2 Institute for Molecular Bioscience, University of Queensland , Brisbane, Australia ., Morsch M; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Hortle E; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Hogan A; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Chow S; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Gwee SS; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Stoddart JJ; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Nicholson G; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia .; 3 ANZAC Research Institute, Concord Hospital, University of Sydney , Sydney, Australia ., Chung R; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia ., Cole NJ; 1 Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University , Sydney, Australia . |
| المصدر: | Zebrafish [Zebrafish] 2017 Feb; Vol. 14 (1), pp. 69-72. Date of Electronic Publication: 2016 Sep 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101225070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8542 (Electronic) Linking ISSN: 15458547 NLM ISO Abbreviation: Zebrafish Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004- |
| مواضيع طبية MeSH: | DNA Transposable Elements* , Gene Transfer Techniques*, Animals, Genetically Modified/*genetics , Nervous System Diseases/*genetics , Neurodegenerative Diseases/*genetics , Zebrafish/*genetics, Animals ; DNA, Recombinant/genetics ; Genetic Vectors ; Green Fluorescent Proteins/genetics ; Promoter Regions, Genetic ; Recombination, Genetic ; Zebrafish/metabolism |
| مستخلص: | Currently there is a lack in fundamental understanding of disease progression of most neurodegenerative diseases, and, therefore, treatments and preventative measures are limited. Consequently, there is a great need for adaptable, yet robust model systems to both investigate elementary disease mechanisms and discover effective therapeutics. We have generated a Tol2 Gateway-compatible toolbox to study neurodegenerative disorders in zebrafish, which includes promoters for astrocytes, microglia and motor neurons, multiple fluorophores, and compatibility for the introduction of genes of interest or disease-linked genes. This toolbox will advance the rapid and flexible generation of zebrafish models to discover the biology of the nervous system and the disease processes that lead to neurodegeneration. |
| فهرسة مساهمة: | Keywords: Tol2 gateway; disease model; neurodegenerative disease; transgenesis |
| المشرفين على المادة: | 0 (DNA Transposable Elements) 0 (DNA, Recombinant) 147336-22-9 (Green Fluorescent Proteins) |
| تواريخ الأحداث: | Date Created: 20160916 Date Completed: 20171011 Latest Revision: 20180116 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1089/zeb.2016.1321 |
| PMID: | 27631880 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1557-8542 |
|---|---|
| DOI: | 10.1089/zeb.2016.1321 |