دورية أكاديمية

Clinical protocol for the management of malignant hyperthermia.

التفاصيل البيبلوغرافية
العنوان: Clinical protocol for the management of malignant hyperthermia.
عنوان ترانسليتريتد: Protocolo clínico asistencial de manejo de la hipertermia maligna.
المؤلفون: Kollmann-Camaiora A; Departamento de Anestesiología y Reanimación, Hospital Universitario La Paz, Madrid, España. Electronic address: and_c@hotmail.com., Alsina E; Departamento de Anestesiología y Reanimación, Hospital Universitario La Paz, Madrid, España., Domínguez A; Departamento de Anestesiología y Reanimación, Hospital Universitario La Paz, Madrid, España., Del Blanco B; Departamento de Anestesiología y Reanimación, Hospital Clínico Universitario San Carlos, Madrid, España., Yepes MJ; Departamento de Anestesiología y Reanimación, Clínica Universidad de Navarra, Pamplona, Navarra, España., Guerrero JL; Departamento de Anestesiología y Reanimación, Hospital Virgen de la Victoria, Málaga, España., García A; Departamento de Anestesiología y Reanimación, Hospital Virgen de la Victoria, Málaga, España.
المصدر: Revista espanola de anestesiologia y reanimacion [Rev Esp Anestesiol Reanim] 2017 Jan; Vol. 64 (1), pp. 32-40. Date of Electronic Publication: 2016 Sep 12.
نوع المنشور: Journal Article; Review
اللغة: English; Spanish; Castilian
بيانات الدورية: Publisher: Elsevier Doyma Country of Publication: Spain NLM ID: 0134516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2340-3284 (Electronic) Linking ISSN: 00349356 NLM ISO Abbreviation: Rev Esp Anestesiol Reanim Subsets: MEDLINE
أسماء مطبوعة: Publication: <2012- > : Barcelona : Elsevier Doyma
Original Publication: Barcelona : Sociedad Espanola De Anestesiologia Y Reanimacion
مواضيع طبية MeSH: Clinical Protocols* , Disease Management*, Malignant Hyperthermia/*therapy, Adolescent ; Adult ; Caffeine/pharmacology ; Calcium Signaling/drug effects ; Child ; Child, Preschool ; Critical Care/methods ; Dantrolene/pharmacology ; Dantrolene/therapeutic use ; Diagnosis, Differential ; Female ; Halothane/pharmacology ; Humans ; Infant ; Infant, Newborn ; Male ; Malignant Hyperthermia/diagnosis ; Malignant Hyperthermia/epidemiology ; Malignant Hyperthermia/physiopathology ; Muscle Contraction/drug effects ; Muscle Fibers, Skeletal/drug effects ; Neuroleptic Malignant Syndrome/diagnosis ; Ryanodine Receptor Calcium Release Channel/drug effects ; Ryanodine Receptor Calcium Release Channel/physiology ; Serotonin Syndrome/diagnosis
مستخلص: Malignant hyperthermia is a hypermetabolic syndrome that appears in susceptible patients after exposure to certain anaesthetic drugs (succinylcholine, inhalation anaesthetics). Its incidence in Spain is 1 in 40,000 adults, with a 10% mortality rate. It is induced by an abnormal regulation of the ryanodine receptors, producing a massive release of calcium from the sarcoplasmic reticulum in the striate muscle. Clinical manifestations include: CO 2 increase, tachycardia, haemodynamic instability, metabolic and respiratory acidosis, profuse sweating, hyperpyrexia, CPK increase, myoglobinuria, kidney failure, disseminated intravascular coagulation (DIC), and ending in cardiac arrest. Dantrolene sodium is a ryanodine receptor antagonist, and inhibits the release of intracellular calcium. Definitive diagnosis is achieved by the exposure of muscle fibres to caffeine and halothane. Protocols can help guarantee a reliable and secure management when this severe event occurs.
(Copyright © 2016 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Publicado por Elsevier España, S.L.U. All rights reserved.)
فهرسة مساهمة: Keywords: Dantrolene sodium; Dantroleno sódico; Hipertermia maligna; Malignant hyperthermia; Receptor de rianodina; Ryanodine receptor
المشرفين على المادة: 0 (Ryanodine Receptor Calcium Release Channel)
3G6A5W338E (Caffeine)
F64QU97QCR (Dantrolene)
UQT9G45D1P (Halothane)
تواريخ الأحداث: Date Created: 20160917 Date Completed: 20180402 Latest Revision: 20180402
رمز التحديث: 20221213
DOI: 10.1016/j.redar.2016.06.004
PMID: 27633384
قاعدة البيانات: MEDLINE
الوصف
تدمد:2340-3284
DOI:10.1016/j.redar.2016.06.004