دورية أكاديمية
Rapid Induction of Therapeutic Hypothermia Using Transnasal High Flow Dry Air.
| العنوان: | Rapid Induction of Therapeutic Hypothermia Using Transnasal High Flow Dry Air. |
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| المؤلفون: | Chava R; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Zviman M; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Raghavan MS; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Halperin H; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Maqbool F; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Geocadin R; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Quinones-Hinojosa A; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Kolandaivelu A; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Rosen BA; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland., Tandri H; Division of Cardiology, Departments of Neuroanesthesia and Neurosurgery, The Johns Hopkins University School of Medicine , Baltimore, Maryland. |
| المصدر: | Therapeutic hypothermia and temperature management [Ther Hypothermia Temp Manag] 2017 Mar; Vol. 7 (1), pp. 50-56. Date of Electronic Publication: 2016 Sep 16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101543518 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2153-7933 (Electronic) Linking ISSN: 21537658 NLM ISO Abbreviation: Ther Hypothermia Temp Manag Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: | Air* , Body Temperature Regulation*, Brain/*physiology , Hypothermia, Induced/*methods , Nasal Mucosa/*physiology , Respiration, Artificial/*methods, Animals ; Female ; Humidity ; Models, Animal ; Sus scrofa ; Time Factors |
| مستخلص: | Early induction of therapeutic hypothermia (TH) is recommended in out-of-hospital cardiac arrest (CA); however, currently no reliable methods exist to initiate cooling. We investigated the effect of high flow transnasal dry air on brain and body temperatures in adult porcine animals. Adult porcine animals (n = 23) under general anesthesia were subject to high flow of transnasal dry air. Mouth was kept open to create a unidirectional airflow, in through the nostrils and out through the mouth. Brain, internal jugular, and aortic temperatures were recorded. The effect of varying airflow rate and the air humidity (0% or 100%) on the temperature profiles were recorded. The degree of brain cooling was measured as the differential temperature from baseline. A 10-minute exposure of high flow dry air caused rapid cooling of brain and gradual cooling of the jugular and the aortic temperatures in all animals. The degree of brain cooling was flow dependent and significantly higher at higher airflow rates (0.8°C ± 0.3°C, 1.03°C ± 0.6°C, and 1.3°C ± 0.7°C for 20, 40, and 80 L, respectively, p < 0.05 for all comparisons). Air temperature had minimal effect on the brain cooling over 10 minutes with similar decrease in temperature at 4°C and 30°C. At a constant flow rate (40 LPM) and temperature, the degree of cooling over 10 minutes during dry air exposure was significantly higher compared to humid air (100% saturation) (1.22°C ± 0.35°C vs. 0.21°C ± 0.12°C, p < 0.001). High flow transnasal dry air causes flow dependent cooling of the brain and the core temperatures in intubated porcine animals. The mechanism of cooling appears to be evaporation of nasal mucus as cooling is mitigated by humidifying the air. This mechanism may be exploited to initiate TH in CA. |
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| فهرسة مساهمة: | Keywords: cardiac arrest; neuroprotection; out-of-hospital cardiac arrest; survival; therapeutic hypothermia |
| تواريخ الأحداث: | Date Created: 20160917 Date Completed: 20170717 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5346959 |
| DOI: | 10.1089/ther.2016.0016 |
| PMID: | 27635468 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2153-7933 |
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| DOI: | 10.1089/ther.2016.0016 |