دورية أكاديمية
أعرض في EDS

In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium.

التفاصيل البيبلوغرافية
العنوان: In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium.
المؤلفون: Eraky MA; Department Parasitology, Faculty of Medicine, Benha University, Benha 13518, Egypt., Aly NS; Department Parasitology, Faculty of Medicine, Benha University, Benha 13518, Egypt., Selem RF; Department Parasitology, Faculty of Medicine, Benha University, Benha 13518, Egypt., El-Kholy AA; Department Parasitology, Faculty of Medicine, Benha University, Benha 13518, Egypt., Rashed GA; Department Parasitology, Faculty of Medicine, Benha University, Benha 13518, Egypt.
المصدر: The Korean journal of parasitology [Korean J Parasitol] 2016 Aug; Vol. 54 (4), pp. 477-84. Date of Electronic Publication: 2016 Aug 31.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: The Korean Society for Parasitology and Tropical Medicine Country of Publication: Korea (South) NLM ID: 9435800 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1738-0006 (Electronic) Linking ISSN: 00234001 NLM ISO Abbreviation: Korean J Parasitol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015-2022: Sŏul : The Korean Society for Parasitology and Tropical Medicine
Original Publication: Seoul, Korea : Korean Society for Parasitology, c1993-2022.
مواضيع طبية MeSH: Integumentary System*, Anthelmintics/*pharmacology , Phytol/*pharmacology , Schistosoma haematobium/*drug effects , Schistosoma haematobium/*ultrastructure, Animals ; Dose-Response Relationship, Drug ; Female ; Locomotion/drug effects ; Male ; Mesocricetus ; Microscopy, Electron, Scanning ; Schistosoma haematobium/physiology ; Snails ; Survival Analysis ; Time Factors
مستخلص: There is renewed interest in natural products as a starting point for discovery of drugs for schistosomiasis. Recent studies have shown that phytol reveals interesting in vivo and in vitro antischistosomal properties against Schistosoma mansoni adult worms. Here, we report the in vitro antischistosomal activity of phytol against Schistosoma haematobium juvenile and adult worms and alterations on the tegumental surface of the worms by means of scanning electron microscopy. The assay, which was carried out with 6 concentrations (25, 50, 75, 100, 125, and 150 μg/ml) of phytol, has shown a promising activity in a dose and time-dependent manner. There was a significant decline in the motility of the worms and a mortality rate of 100% was found at 48 hr after they had been exposed to phytol in the concentration of 150 μg/ml. Male worms were more susceptible. On the ultrastructural level, phytol also induced tegumental peeling, disintegration of tubercles and spines in addition to morphological disfiguring of the oral and ventral suckers. This report provides the first evidence that phytol is able to kill S. haematobium of different ages, and emphasizes that it is a promising natural product that could be used for development of a new schistosomicidal agent.
Competing Interests: The authors declare that there is no conflict of interest.
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فهرسة مساهمة: Keywords: Schistosoma haematobium; adult; in vitro; juvenile; phytol; schistosomicidal activity
المشرفين على المادة: 0 (Anthelmintics)
150-86-7 (Phytol)
تواريخ الأحداث: Date Created: 20160924 Date Completed: 20170404 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5040092
DOI: 10.3347/kjp.2016.54.4.477
PMID: 27658600
قاعدة البيانات: MEDLINE
الوصف
تدمد:1738-0006
DOI:10.3347/kjp.2016.54.4.477