دورية أكاديمية
أعرض في EDS

Long-term follow-up of HTLV-1 proviral load in asymptomatic carriers and in incident cases of HAM/TSP: what is its relevance as a prognostic marker for neurologic disease?

التفاصيل البيبلوغرافية
العنوان: Long-term follow-up of HTLV-1 proviral load in asymptomatic carriers and in incident cases of HAM/TSP: what is its relevance as a prognostic marker for neurologic disease?
المؤلفون: Martins ML; Research Department, Minas Gerais State Blood Center (Fundação Hemominas), Belo Horizonte, Brazil. marina.martins@hemominas.mg.gov.br.; Interdisciplinary HTLV Research Group (GIPH), Belo Horizonte, Brazil. marina.martins@hemominas.mg.gov.br.; Serviço de Pesquisa, Fundação Centro de Hematologia e Hemoterapia de Minas Gerais, Fundação HEMOMINAS, Alameda Ezequiel Dias, 321, Bairro Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-110, Brazil. marina.martins@hemominas.mg.gov.br., Guimarães JC; Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil., Ribas JG; Interdisciplinary HTLV Research Group (GIPH), Belo Horizonte, Brazil., Romanelli LC; Research Department, Minas Gerais State Blood Center (Fundação Hemominas), Belo Horizonte, Brazil.; Interdisciplinary HTLV Research Group (GIPH), Belo Horizonte, Brazil., de Freitas Carneiro-Proietti AB; Research Department, Minas Gerais State Blood Center (Fundação Hemominas), Belo Horizonte, Brazil.; Interdisciplinary HTLV Research Group (GIPH), Belo Horizonte, Brazil.
المصدر: Journal of neurovirology [J Neurovirol] 2017 Feb; Vol. 23 (1), pp. 125-133. Date of Electronic Publication: 2016 Sep 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 9508123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-2443 (Electronic) Linking ISSN: 13550284 NLM ISO Abbreviation: J Neurovirol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Springer
Original Publication: Houndmills, Basingstoke, Hampshire ; New York, NY : Stockton Press, c1995-
مواضيع طبية MeSH: Host-Parasite Interactions*, DNA, Viral/*genetics , Human T-lymphotropic virus 1/*growth & development , Paraparesis, Tropical Spastic/*diagnosis , Proviruses/*growth & development , Viral Load/*genetics, Adult ; Aged ; Asymptomatic Diseases ; Biomarkers/analysis ; Carrier State ; DNA, Viral/blood ; Female ; Human T-lymphotropic virus 1/genetics ; Humans ; Male ; Middle Aged ; Paraparesis, Tropical Spastic/blood ; Paraparesis, Tropical Spastic/pathology ; Paraparesis, Tropical Spastic/virology ; Prognosis ; Prospective Studies ; Proviruses/genetics
مستخلص: HTLV-1 proviral load (pvl) is an important risk marker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), but its value as prognostic marker is not well defined. Long-term prospective cohort studies are necessary to clarify this question. Here, we analyzed HTLV-1 pvl in the peripheral blood of 82 asymptomatic carriers (AC; 351 samples), 12 HAM/TSP patients (HAM; 46 samples), and six incident cases of HAM/TSP (iHAM), with serial samples collected before (n = 10) and after (n = 20) the disease onset. The mean interval of follow-up was 10 years in the AC group and 8 years in HAM and iHAM groups. pvl was not significantly different between the first and last measurements in the three groups, but there was a trend to decrease over time. Coefficient of variation of pvl was significantly lower in the AC group than in HAM (p = 0.015) and iHAM (p = 0.022) patients. AC and HAM individuals showed a significant and strong positive correlation between the first and last measurements of pvl, but not iHAM subjects. All individuals who developed HAM/TSP during the follow-up had high pvl level (>1 %) before the onset of disease, but a typical increase in pvl was not observed in that period. The data suggest that there is a trend to reach an equilibrium plateau of pvl over time, characteristic of each individual. A significant rate of AC keeps high pvl levels for a long time without developing clinical symptoms associated to HTLV-1 infection. Thus, serial quantification of pvl in the peripheral blood does not seem to be a good prognostic marker for HAM/TSP.
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فهرسة مساهمة: Keywords: HAM/TSP; HTLV-1; Marker; Prognosis; Progression; Proviral load
المشرفين على المادة: 0 (Biomarkers)
0 (DNA, Viral)
تواريخ الأحداث: Date Created: 20160929 Date Completed: 20180206 Latest Revision: 20181113
رمز التحديث: 20221213
DOI: 10.1007/s13365-016-0484-x
PMID: 27678093
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-2443
DOI:10.1007/s13365-016-0484-x