دورية أكاديمية
Cortical flow aligns actin filaments to form a furrow.
| العنوان: | Cortical flow aligns actin filaments to form a furrow. |
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| المؤلفون: | Reymann AC; Biotechnology Center, Technische Universität Dresden, Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany., Staniscia F; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany., Erzberger A; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany., Salbreux G; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; The Francis Crick Institute, London, United Kingdom., Grill SW; Biotechnology Center, Technische Universität Dresden, Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany. |
| المصدر: | ELife [Elife] 2016 Oct 10; Vol. 5. Date of Electronic Publication: 2016 Oct 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012- |
| مواضيع طبية MeSH: | Cytokinesis* , Protein Multimerization*, Actomyosin/*metabolism , Caenorhabditis elegans/*physiology , Zygote/*physiology, Animals |
| مستخلص: | Cytokinesis in eukaryotic cells is often accompanied by actomyosin cortical flow. Over 30 years ago, Borisy and White proposed that cortical flow converging upon the cell equator compresses the actomyosin network to mechanically align actin filaments. However, actin filaments also align via search-and-capture, and to what extent compression by flow or active alignment drive furrow formation remains unclear. Here, we quantify the dynamical organization of actin filaments at the onset of ring assembly in the C. elegans zygote, and provide a framework for determining emergent actomyosin material parameters by the use of active nematic gel theory. We characterize flow-alignment coupling, and verify at a quantitative level that compression by flow drives ring formation. Finally, we find that active alignment enhances but is not required for ring formation. Our work characterizes the physical mechanisms of actomyosin ring formation and highlights the role of flow as a central organizer of actomyosin network architecture. Competing Interests: The authors declare that no competing interests exist. |
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| معلومات مُعتمدة: | 21144 United Kingdom CRUK_ Cancer Research UK; FC001317 United Kingdom MRC_ Medical Research Council; FC001317 United Kingdom ARC_ Arthritis Research UK; FC001317 United Kingdom CRUK_ Cancer Research UK; FC001317 United Kingdom CRUK_ Cancer Research UK; FC001317 United Kingdom WT_ Wellcome Trust; FC001317 United Kingdom MRC_ Medical Research Council; FC001317 United Kingdom WT_ Wellcome Trust; United Kingdom WT_ Wellcome Trust; 281903 International ERC_ European Research Council |
| فهرسة مساهمة: | Keywords: C. elegans; actin; active matter; biophysics; cell biology; cytokinesis; cytoskeleton; nematic gel; structural biology |
| المشرفين على المادة: | 9013-26-7 (Actomyosin) |
| تواريخ الأحداث: | Date Created: 20161011 Date Completed: 20171031 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC5117871 |
| DOI: | 10.7554/eLife.17807 |
| PMID: | 27719759 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2050-084X |
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| DOI: | 10.7554/eLife.17807 |