دورية أكاديمية
A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome.
| العنوان: | A continuum of admixture in the Western Hemisphere revealed by the African Diaspora genome. |
|---|---|
| المؤلفون: | Mathias RA; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.; Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA., Taub MA; Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA., Gignoux CR; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., Fu W; Department of Genomic Sciences, University of Washington, Seattle, Washington 98195, USA., Musharoff S; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Vergara C; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Torgerson DG; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA., Pino-Yanes M; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.; CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid 28029, Spain., Shringarpure SS; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., Huang L; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Rafaels N; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Boorgula MP; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Johnston HR; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA., Ortega VE; Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Levin AM; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan 48202, USA., Song W; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA., Torres R; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California 94158, USA., Padhukasahasram B; Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan 48202, USA., Eng C; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA., Mejia-Mejia DA; Centro de Neumologia y Alergias, San Pedro Sula 21102, Honduras.; Faculty of Medicine, Centro Medico de la Familia, San Pedro Sula 21102, Honduras., Ferguson T; Tropical Medicine Research Institute, The University of the West Indies, St. Michael BB11115, Barbados., Qin ZS; Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322, USA., Scott AF; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Yazdanbakhsh M; Department of Parasitology, Leiden University Medical Center, Leiden 2333ZA, The Netherlands., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA., Marrugo J; Instituto de Investigaciones Immunologicas, Universidad de Cartagena, Cartagena 130000, Colombia., Lange LA; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA., Kumar R; Department of Pediatrics, Northwestern University, Chicago, Illinois 60637, USA.; The Ann &Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois 60637, USA., Avila PC; Department of Medicine, Northwestern University, Chicago, Illinois 60637, USA., Williams LK; Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan 48202, USA.; Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan 48202, USA., Watson H; Faculty of Medical Sciences Cave Hill Campus, The University of the West Indies, Bridgetown BB11000, Barbados.; Queen Elizabeth Hospital, The University of the West Indies, St. Michael BB11115, Barbados., Ware LB; Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA.; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee 37232, USA., Olopade C; Department of Medicine and Center for Global Health, University of Chicago, Chicago, Illinois 60637, USA., Olopade O; Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA., Oliveira R; Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz, Salvador 40296-710, Brazil., Ober C; Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA., Nicolae DL; Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA.; Department of Statistics, University of Chicago, Chicago, Illinois 60637, USA., Meyers D; Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Mayorga A; Centro de Neumologia y Alergias, San Pedro Sula 21102, Honduras., Knight-Madden J; Tropical Medicine Research Institute, The University of the West Indies, St. Michael BB11115, Barbados., Hartert T; Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA., Hansel NN; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA., Foreman MG; Pulmonary and Critical Care Medicine, Morehouse School of Medicine, Atlanta, Georgia 30310, USA., Ford JG; Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA.; Department of Medicine, The Brooklyn Hospital Center, Brooklyn, New York 11201, USA., Faruque MU; National Human Genome Center, Howard University College of Medicine, Washington DC 20059, USA., Dunston GM; National Human Genome Center, Howard University College of Medicine, Washington DC 20059, USA.; Department of Microbiology, Howard University College of Medicine, Washington DC 20059, USA., Caraballo L; Institute for Immunological Research, Universidad de Cartagena, Cartagena 130000, Colombia., Burchard EG; Department of Medicine, University of California, San Francisco, San Francisco, California 94143, USA.; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA., Bleecker E; Center for Human Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA., Araujo MI; Immunology Service, Universidade Federal da Bahia, Salvador 401110170, Brazil., Herrera-Paz EF; Centro de Neumologia y Alergias, San Pedro Sula 21102, Honduras.; Faculty of Medicine, Centro Medico de la Familia, San Pedro Sula 21102, Honduras.; Facultad de Medicina, Universidad Catolica de Honduras, San Pedro Sula 21102, Honduras., Gietzen K; Illumina, Inc., San Diego, California 92122, USA., Grus WE; Knome Inc., Cambridge, Massachusetts 02141, USA., Bamshad M; Department of Pediatrics, University of Washington, Seattle, Washington 98195, USA., Bustamante CD; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., Kenny EE; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA.; Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143, USA.; California Institute for Quantitative Biosciences, University of California, San Francisco, California 94143, USA., Beaty TH; Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA., Ruczinski I; Department of Biostatistics, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA., Akey J; Department of Genomic Sciences, University of Washington, Seattle, Washington 98195, USA., Barnes KC; Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21224, USA.; Department of Epidemiology, Bloomberg School of Public Health, JHU, Baltimore, Maryland 21205, USA. |
| مؤلفون مشاركون: | CAAPA |
| المصدر: | Nature communications [Nat Commun] 2016 Oct 11; Vol. 7, pp. 12522. Date of Electronic Publication: 2016 Oct 11. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Gene Flow* , Genome, Human* , Human Migration*, Black People/*genetics, Base Sequence ; DNA, Intergenic/genetics ; Female ; Genetic Heterogeneity ; Geography ; Humans ; Male ; Phylogeny ; Polymorphism, Single Nucleotide/genetics ; Sexism |
| مستخلص: | The African Diaspora in the Western Hemisphere represents one of the largest forced migrations in history and had a profound impact on genetic diversity in modern populations. To date, the fine-scale population structure of descendants of the African Diaspora remains largely uncharacterized. Here we present genetic variation from deeply sequenced genomes of 642 individuals from North and South American, Caribbean and West African populations, substantially increasing the lexicon of human genomic variation and suggesting much variation remains to be discovered in African-admixed populations in the Americas. We summarize genetic variation in these populations, quantifying the postcolonial sex-biased European gene flow across multiple regions. Moreover, we refine estimates on the burden of deleterious variants carried across populations and how this varies with African ancestry. Our data are an important resource for empowering disease mapping studies in African-admixed individuals and will facilitate gene discovery for diseases disproportionately affecting individuals of African ancestry. Competing Interests: Nadia N. Hansel has a consulting relationship with GSK (Advisory Board). All other authors declare no competing financial interests. |
| References: | Am Rev Respir Dis. 1990 Dec;142(6 Pt 1):1351-8. (PMID: 2252253) Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5154-62. (PMID: 21383195) Balkan J Med Genet. 2012 Dec;15(2):7-14. (PMID: 24052726) PLoS One. 2011 Jan 06;6(1):e14495. (PMID: 21253579) Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):786-91. (PMID: 20080753) PLoS Genet. 2006 Dec;2(12):e190. (PMID: 17194218) Annu Rev Genet. 2007;41:539-64. (PMID: 18076332) Science. 2012 Jul 6;337(6090):64-9. (PMID: 22604720) Hum Biol. 1981 Feb;53(1):87-103. (PMID: 7239494) Nat Genet. 2004 Nov;36(11 Suppl):S21-7. (PMID: 15507999) Nat Protoc. 2009;4(7):1073-81. (PMID: 19561590) J Allergy Clin Immunol. 2010 Feb;125(2):336-346.e4. (PMID: 19910028) Am J Hum Genet. 2013 Aug 8;93(2):278-88. (PMID: 23910464) Science. 2012 Jul 6;337(6090):100-4. (PMID: 22604722) Am J Hum Genet. 2015 Sep 3;97(3):404-18. (PMID: 26299365) Proc Biol Sci. 1997 Aug 22;264(1385):1217-24. (PMID: 9308194) Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8696-701. (PMID: 26124090) Am J Hum Genet. 2007 Nov;81(5):1084-97. (PMID: 17924348) Am J Hum Genet. 2007 Jun;80(6):1171-8. (PMID: 17503334) Nature. 2010 Oct 28;467(7319):1061-73. (PMID: 20981092) Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2:8954-61. (PMID: 20445096) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):E440-9. (PMID: 26712023) Am J Hum Genet. 2014 Oct 2;95(4):421-36. (PMID: 25279984) Forensic Sci Int Genet. 2008 Dec;3(1):e5-10. (PMID: 19083858) Nature. 2007 Oct 18;449(7164):913-8. (PMID: 17943131) Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):757-62. (PMID: 24379384) Science. 2014 Jun 20;344(6190):1346-8. (PMID: 24948725) Nat Genet. 2014 Mar;46(3):220-4. (PMID: 24509481) PLoS Med. 2008 Apr 22;5(4):e66. (PMID: 18433290) Science. 2012 May 11;336(6082):740-3. (PMID: 22582263) Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11983-8. (PMID: 21730125) PLoS Genet. 2013 Nov;9(11):e1003925. (PMID: 24244192) Hum Mutat. 2009 Feb;30(2):E386-94. (PMID: 18853457) Pediatr Pulmonol. 2014 Aug;49(8):800-6. (PMID: 24167151) PLoS Genet. 2015 Dec 04;11(12):e1005602. (PMID: 26636962) PLoS Genet. 2016 May 27;12(5):e1006059. (PMID: 27232753) Am J Respir Crit Care Med. 2008 Jun 1;177(11):1194-200. (PMID: 18310477) Hum Biol. 2004 Feb;76(1):77-86. (PMID: 15222681) Nat Genet. 2015 Feb;47(2):126-31. (PMID: 25581429) Am J Epidemiol. 2021 Oct 1;190(10):1977-1992. (PMID: 33861317) Nat Commun. 2010 Nov 30;1:131. (PMID: 21119644) Hum Mutat. 2011 Jan;32(1):25-32. (PMID: 20960467) Nat Genet. 2014 Mar;46(3):310-5. (PMID: 24487276) Genome Biol. 2009;10(12):R141. (PMID: 20025784) Mol Biol Evol. 2009 Sep;26(9):2109-24. (PMID: 19535740) Nat Methods. 2010 Apr;7(4):248-9. (PMID: 20354512) Am J Hum Genet. 2013 Nov 7;93(5):840-51. (PMID: 24207118) Genome Res. 2009 Sep;19(9):1655-64. (PMID: 19648217) Science. 2013 Aug 2;341(6145):562-5. (PMID: 23908239) Am J Phys Anthropol. 2005 Dec;128(4):855-60. (PMID: 16047324) Genome Res. 2010 Jan;20(1):110-21. (PMID: 19858363) PLoS Genet. 2013 May;9(5):e1003520. (PMID: 23737753) |
| معلومات مُعتمدة: | R01 ES015794 United States ES NIEHS NIH HHS; K24 AI077930 United States AI NIAID NIH HHS; G12 RR003048 United States RR NCRR NIH HHS; P50 CA125183 United States CA NCI NIH HHS; U01 CA161032 United States CA NCI NIH HHS; RC2 HL101543 United States HL NHLBI NIH HHS; R01 AI079139 United States AI NIAID NIH HHS; HHSN268201300048C United States HL NHLBI NIH HHS; R01 HL089856 United States HL NHLBI NIH HHS; R01 HL087699 United States HL NHLBI NIH HHS; R21 HG004751 United States HG NHGRI NIH HHS; U01 HL049596 United States HL NHLBI NIH HHS; U19 AI095227 United States AI NIAID NIH HHS; R37 HL068546 United States HL NHLBI NIH HHS; P30 DK020595 United States DK NIDDK NIH HHS; R01 HL069167 United States HL NHLBI NIH HHS; R01 HL089897 United States HL NHLBI NIH HHS; UL1 TR000445 United States TR NCATS NIH HHS; U54 MD007588 United States MD NIMHD NIH HHS; K23 HL004464 United States HL NHLBI NIH HHS; R21 HG007233 United States HG NHGRI NIH HHS; U01 HL089897 United States HL NHLBI NIH HHS; R21 CA178706 United States CA NCI NIH HHS; U19 AI095230 United States AI NIAID NIH HHS; R01 HG007644 United States HG NHGRI NIH HHS; R01 AI114555 United States AI NIAID NIH HHS; U01 HL089856 United States HL NHLBI NIH HHS; RC2 HL101651 United States HL NHLBI NIH HHS; HHSN268201300049C United States HL NHLBI NIH HHS; HHSN268201300047C United States HL NHLBI NIH HHS; R01 HL104608 United States HL NHLBI NIH HHS; HHSN268201300050C United States HL NHLBI NIH HHS; U10 HL109164 United States HL NHLBI NIH HHS; T32 HG000044 United States HG NHGRI NIH HHS; R01 HL117004 United States HL NHLBI NIH HHS; P60 MD006902 United States MD NIMHD NIH HHS; R01 HL072414 United States HL NHLBI NIH HHS; UL1 RR024975 United States RR NCRR NIH HHS; United Kingdom WT_ Wellcome Trust; HHSN268201300046C United States HL NHLBI NIH HHS; S06 GM008016 United States GM NIGMS NIH HHS; K01 HL092601 United States HL NHLBI NIH HHS; R21 HL112656 United States HL NHLBI NIH HHS; R01 HL088133 United States HL NHLBI NIH HHS; U01 HL081332 United States HL NHLBI NIH HHS; T32 GM007175 United States GM NIGMS NIH HHS; R01 HL118267 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Investigator: M Campbell; S Chavan; C Foster; L Gao; E Horowitz; R Ortiz; J Potee; J Gao; Y Hu; M Hansen; A Deshpande; DP Locke; L Grammer; KY Kim; R Schleimer; FM De La Vega; ZA Szpiech; O Oluwole; G Arinola; A Correa; S Musani; J Chong; D Nickerson; A Reiner; P Maul; T Maul; B Martinez; C Meza; G Ayestas; P Landaverde-Torres; SO Erazo; R Martinez; LF Mayorga; H Ramos; A Saenz; G Varela; OM Vasquez; M Samms-Vaughan; RJ Wilks; A Adegnika; U Ateba-Ngoa |
| المشرفين على المادة: | 0 (DNA, Intergenic) |
| تواريخ الأحداث: | Date Created: 20161012 Date Completed: 20180905 Latest Revision: 20240326 |
| رمز التحديث: | 20240326 |
| مُعرف محوري في PubMed: | PMC5062574 |
| DOI: | 10.1038/ncomms12522 |
| PMID: | 27725671 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/ncomms12522 |