دورية أكاديمية
[Relationship between serum erythropoietin levels and brain injury in preterm infants].
| العنوان: | [Relationship between serum erythropoietin levels and brain injury in preterm infants]. |
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| المؤلفون: | Chen GF; Department of Pediatrics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518035, China. szchengf@163.com., Li HT, Huang JJ, Wang ZX, Li Y, Yang CZ, Wu BQ, Liu WL, Liu LH, Kong Q, Liu RT |
| المصدر: | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics [Zhongguo Dang Dai Er Ke Za Zhi] 2016 Oct; Vol. 18 (10), pp. 947-952. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Zhongguo dang dai er ke za zhi she Country of Publication: China NLM ID: 100909956 Publication Model: Print Cited Medium: Print ISSN: 1008-8830 (Print) Linking ISSN: 10088830 NLM ISO Abbreviation: Zhongguo Dang Dai Er Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Changsha : Zhongguo dang dai er ke za zhi she, 1999- |
| مواضيع طبية MeSH: | Brain Injuries/*blood , Erythropoietin/*blood , Infant, Premature/*blood, Brain Injuries/epidemiology ; Female ; Humans ; Infant, Newborn ; Male ; Myelin Basic Protein/blood |
| مستخلص: | Objective: To study the relationship between the levels of erythropoietin (EPO) in serum and brain injury in preterm infants. Methods: Three hundred and four preterm infants (gestational age: 28-34 weeks) born between October 2014 and September 2015 were enrolled in this study. Brain injury was diagnosed using cerebral ultrasound and MRI. The levels of EPO, S100 protein, neuron-specific enolase (NSE) and myelin basic protein (MBP) in serum were detected using ELISA. To compare the incidence of brain injury in different serum EPO levels in preterm infants, and the relationship between brain injury and serum EPO levels was analyzed. Results: The incidence rate of brain injury in preterm infants was 41.1% (125/304). The incidence rate of brain injury in the low EPO level group was significantly higher than that in the middle-high EPO level groups (P<0.01). The serum levels of S100 protein, NSE, and MBP in the brain injury groups were significantly higher than in the control group (P<0.01). The serum EPO levels were negatively correlated with serum S100 protein concentration and NSE levels (P<0.05). According to the multiple logistic regression analysis, low gestational age, low birth weight, asphyxia, prolonged mechanical ventilation, anemia and low serum EPO levels were the risk factor for brain injury in preterm infants. Conclusions: There is a higher incidence rate of brain injury in preterm infants with lower serum EPO levels. The serum EPO levels may be correlated with brain injury in preterm infants. |
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| المشرفين على المادة: | 0 (Myelin Basic Protein) 11096-26-7 (Erythropoietin) |
| تواريخ الأحداث: | Date Created: 20161019 Date Completed: 20170308 Latest Revision: 20231111 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7389545 |
| PMID: | 27751209 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1008-8830 |
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