دورية أكاديمية
أعرض في EDS

Multi-institutional phase II study on the feasibility of liver resection following preoperative mFOLFOX6 therapy for resectable liver metastases from colorectal cancers.

التفاصيل البيبلوغرافية
العنوان: Multi-institutional phase II study on the feasibility of liver resection following preoperative mFOLFOX6 therapy for resectable liver metastases from colorectal cancers.
المؤلفون: Nagayama S; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan. nagayama@kuhp.kyoto-u.ac.jp., Hasegawa S; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Hida K; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Kawada K; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Hatano E; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Nakamura K; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Seo S; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Taura K; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Yasuchika K; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Matsuo T; Department of Surgery, Shiga Medical Center for Adults, 5-4-30 Moriyama, Moriyama City, Shiga, Japan., Zaima M; Department of Surgery, Shiga Medical Center for Adults, 5-4-30 Moriyama, Moriyama City, Shiga, Japan., Kanazawa A; Department of Surgery, Osaka Red Cross Hospital, 5-30 Fudegasaki-cho, Ten-noji-ku, Osaka, Japan., Terajima H; Department of Surgery, Kitano Hospital, 2-4-20 Oogimachi, Kita-ku, Osaka, Japan., Tada M; Department of Surgery, Kitano Hospital, 2-4-20 Oogimachi, Kita-ku, Osaka, Japan., Adachi Y; Department of Surgery, Saiseikai Noe Hospital, 1-3-25 Furuichi, Joto-ku, Osaka, Japan., Nishitai R; Department of Surgery, Kyoto Katsura Hospital, 17 Hirao-cho, Yamada, Nishikyo-ku, Kyoto, Japan., Manaka D; Department of Surgery, Kyoto Katsura Hospital, 17 Hirao-cho, Yamada, Nishikyo-ku, Kyoto, Japan., Yoshimura T; Department of Surgery, Tenri Yorozu Hospital, 200 Mishima-cho, Tenri, Nara, Japan., Doi K; Department of Surgery, Fukui Red Cross Hospital, 2-4-1 Tsukimi, Fukui, Japan., Horimatsu T; Department of Medical Oncology, Kyoto University Hospital, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, Japan., Mitsuyoshi A; Department of Surgery, Mitsubishi Kyoto Hospital, 1 Gosho-cho, Katsura, Sakyo-ku, Kyoto, Japan., Yoshimura K; Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, Japan., Niimi M; Translational Research Center, Kyoto University Hospital, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, Japan., Matsumoto S; Department of Medical Oncology, Kyoto University Hospital, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, Japan., Sakai Y; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan., Uemoto S; Department of Surgery, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Sho-go-in, Sakyo-ku, Kyoto, 606-8507, Japan.
المصدر: International journal of clinical oncology [Int J Clin Oncol] 2017 Apr; Vol. 22 (2), pp. 316-323. Date of Electronic Publication: 2016 Oct 17.
نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Tokyo Country of Publication: Japan NLM ID: 9616295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1437-7772 (Electronic) Linking ISSN: 13419625 NLM ISO Abbreviation: Int J Clin Oncol Subsets: MEDLINE
أسماء مطبوعة: Publication: 1998- : Tokyo : Springer-Verlag Tokyo
Original Publication: Tokyo : Published for the Japan Society of Clinical Oncology by Churchill Livingstone, c1996-
مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Colorectal Neoplasms/*therapy , Liver Neoplasms/*therapy, Adult ; Aged ; Aged, 80 and over ; Colorectal Neoplasms/pathology ; Combined Modality Therapy ; Feasibility Studies ; Female ; Fluorouracil/administration & dosage ; Hepatectomy ; Humans ; Leucovorin/administration & dosage ; Liver Neoplasms/secondary ; Male ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Organoplatinum Compounds/administration & dosage ; Oxaliplatin ; Prognosis ; Prospective Studies ; Survival Rate ; Young Adult
مستخلص: Background: Although liver resection combined with preoperative chemotherapy is expected to improve outcomes of patients with resectable colorectal liver metastasis (CRLM), there is as yet insufficient clinical evidence supporting the efficacy of preoperative systemic chemotherapy. The aim of this phase II study was to assess the feasibility and efficacy of preoperative FOLFOX systemic chemotherapy for patients with initially resectable CRLM.
Methods: A prospective multi-institutional phase II study was conducted to evaluate the feasibility and efficacy of preoperative chemotherapy for resectable CRLM (ClinicalTrials.gov identifier number NCT00594529). Patients were scheduled to receive 6 cycles of mFOLFOX6 therapy before liver surgery. The primary endpoint was the macroscopic curative resection rate.
Results: A total of 30 patients were included in this study. Two patients who were diagnosed with hepatocellular and intrahepatic cholangiocellular carcinoma based on pathology were excluded from the analysis. More than half of the patients (57 %) had solitary liver metastasis. The completion rate of preoperative chemotherapy was 64.3 % and the response rate was 53.6 %. Two patients were unable to proceed to liver resections due to disease progression and severe postoperative complications following primary tumor resection. Macroscopic curative resection was obtained in 89.3 % of eligible patients. Postoperative mortality and severe complication (≥Gr. 3) rates were 0 and 11 %, respectively. The 3-year overall and progression-free survival rates were 81.9 and 47.4 %, respectively.
Conclusion: Our phase II study demonstrated the feasibility of liver resection combined with preoperative mFOLFOX6 therapy in patients with initially resectable CRLM. Further study is warranted to address the oncological effects of preoperative chemotherapy.
References: J Clin Oncol. 1997 Mar;15(3):938-46. (PMID: 9060531)
Br J Surg. 2007 Mar;94(3):274-86. (PMID: 17315288)
Ann Surg. 2008 Jan;247(1):118-24. (PMID: 18156931)
J Natl Cancer Inst. 2000 Feb 2;92 (3):205-16. (PMID: 10655437)
Br J Surg. 1990 Nov;77(11):1241-6. (PMID: 2253003)
Lancet Oncol. 2013 Nov;14(12):1208-15. (PMID: 24120480)
Ann Surg Oncol. 2013 Dec;20(13):4312-21. (PMID: 23897009)
J Hepatobiliary Pancreat Sci. 2014 Dec;21(12):881-8. (PMID: 25155418)
J Clin Oncol. 2006 Nov 1;24(31):4983-90. (PMID: 17075116)
PLoS One. 2014 Jan 21;9(1):e86543. (PMID: 24466143)
Eur J Surg Oncol. 2013 Apr;39(4):380-5. (PMID: 23351680)
J Surg Oncol. 2012 Jan;105(1):55-9. (PMID: 21842519)
J Am Coll Surg. 2005 Jun;200(6):845-53. (PMID: 15922194)
Surgeon. 2015 Apr;13(2):83-90. (PMID: 25257725)
Ann Surg. 2006 Jan;243(1):1-7. (PMID: 16371728)
Ann Surg. 2002 Jun;235(6):759-66. (PMID: 12035031)
J Surg Oncol. 2012 May;105(6):511-9. (PMID: 22065486)
Lancet. 2008 Mar 22;371(9617):1007-16. (PMID: 18358928)
Ann Surg. 2006 Aug;244(2):254-9. (PMID: 16858188)
Oncologist. 2009 Nov;14 (11):1095-105. (PMID: 19880627)
J Clin Oncol. 2006 May 1;24(13):2065-72. (PMID: 16648507)
Ann Oncol. 2004 Mar;15(3):460-6. (PMID: 14998849)
Br J Surg. 2006 Apr;93(4):465-74. (PMID: 16523446)
World J Surg. 2012 Jan;36(1):157-63. (PMID: 22086255)
J Am Coll Surg. 2014 Mar;218(3):412-22. (PMID: 24468222)
J Clin Oncol. 2006 Nov 1;24(31):4976-82. (PMID: 17075115)
Ann Surg. 2010 Nov;252(5):774-87. (PMID: 21037433)
Cancer. 1996 Apr 1;77(7):1254-62. (PMID: 8608500)
J Clin Oncol. 2008 Oct 20;26(30):4906-11. (PMID: 18794541)
Cancer. 2007 Feb 15;109(4):718-26. (PMID: 17238180)
Ann Surg. 2004 Aug;240(2):205-13. (PMID: 15273542)
J Gastrointest Surg. 2003 Dec;7(8):1082-8. (PMID: 14675719)
Br J Cancer. 2006 Apr 10;94(7):982-99. (PMID: 16538219)
Chemotherapy. 2008;54(5):395-403. (PMID: 18781065)
Hepatogastroenterology. 2001 Nov-Dec;48(42):1680-4. (PMID: 11813600)
Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21. (PMID: 10493478)
J Am Coll Surg. 2007 May;204(5):753-61; discussion 761-3. (PMID: 17481478)
Langenbecks Arch Surg. 2012 Mar;397(3):397-405. (PMID: 22198370)
فهرسة مساهمة: Keywords: Colorectal liver metastasis; Liver resection; Preoperative mFOLFOX6 therapy
سلسلة جزيئية: ClinicalTrials.gov NCT00594529
المشرفين على المادة: 0 (Organoplatinum Compounds)
04ZR38536J (Oxaliplatin)
Q573I9DVLP (Leucovorin)
U3P01618RT (Fluorouracil)
تواريخ الأحداث: Date Created: 20161019 Date Completed: 20170523 Latest Revision: 20181202
رمز التحديث: 20231215
DOI: 10.1007/s10147-016-1050-5
PMID: 27752787
قاعدة البيانات: MEDLINE
الوصف
تدمد:1437-7772
DOI:10.1007/s10147-016-1050-5