دورية أكاديمية
In vitro and ex vivo activity of Melaleuca alternifolia against protoscoleces of Echinococcus ortleppi.
| العنوان: | In vitro and ex vivo activity of Melaleuca alternifolia against protoscoleces of Echinococcus ortleppi. |
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| المؤلفون: | Monteiro DU; Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., Azevedo MI; Department of Industrial Pharmacy,Postgraduation Program in Veterinary Medicine, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., Weiblen C; Department of Industrial Pharmacy,Postgraduation Program in Veterinary Medicine, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., DE Avila Botton S; Department of Industrial Pharmacy,Postgraduation Program in Veterinary Medicine, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., Funk NL; Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., DE Bona DA Silva C; Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., Zanette RA; Postgraduation Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul,Porto Alegre,Brazil., Schwanz TG; Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil., DE LA Rue ML; Postgraduation Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria, UFSM,Santa Maria,Brazil. |
| المصدر: | Parasitology [Parasitology] 2017 Feb; Vol. 144 (2), pp. 214-219. Date of Electronic Publication: 2016 Oct 20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 0401121 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8161 (Electronic) Linking ISSN: 00311820 NLM ISO Abbreviation: Parasitology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, New York, Cambridge University Press. |
| مواضيع طبية MeSH: | Melaleuca*, Anthelmintics/*pharmacology , Echinococcus/*drug effects , Tea Tree Oil/*pharmacology, Animals |
| مستخلص: | Cystic echinococcosis is a zoonotic disease of difficult diagnosis and treatment. The use of protoscolicidal agents in procedures is of utmost importance for treatment success. This study was aimed at analysing the in vitro and ex vivo activity of Melaleuca alternifolia oil (tea tree oil - TTO), its nanoemulsion formulation (NE-TTO) and its major component (terpinen-4-ol) against Echinococcus ortleppi protoscoleces obtained from cattle. Concentrations of 2·5, 5 and 10 mg mL-1 of TTO, 10 mg mL-1 of NE-TTO and 1, 1·5 and 2 mg mL-1 of terpinen-4-ol were evaluated in vitro against protoscoleces at 5, 10, 15 and 30 min. TTO was also injected directly into hydatid cysts (ex vivo analysis, n = 20) and the viability of protoscoleces was evaluated at 5, 15 and 30 min. The results indicated protoscolicidal effect at all tested formulations and concentrations. Terpinen-4-ol (2 mg mL-1) activity was superior when compared with the highest concentration of TTO. NE-TTO reached a gradual protoscolicidal effect. TTO at 20 mg mL-1 showed 90% protoscolicidal action in hydatid cysts at 5 min. The results showed that TTO affects the viability of E. ortleppi protoscoleces, suggesting a new protoscolicidal option to the treatment of cystic equinococcosis. |
| فهرسة مساهمة: | Keywords: Echinococcus ortleppi; nanoemulsions; protoscolicidal; tea tree oil |
| المشرفين على المادة: | 0 (Anthelmintics) 68647-73-4 (Tea Tree Oil) |
| تواريخ الأحداث: | Date Created: 20161021 Date Completed: 20171006 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1017/S0031182016001621 |
| PMID: | 27762176 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1469-8161 |
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| DOI: | 10.1017/S0031182016001621 |