دورية أكاديمية
أعرض في EDS

Vitamin D Deficiency Increases the Risk of Adverse Neonatal Outcomes in Gestational Diabetes.

التفاصيل البيبلوغرافية
العنوان: Vitamin D Deficiency Increases the Risk of Adverse Neonatal Outcomes in Gestational Diabetes.
المؤلفون: Weinert LS; Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Reichelt AJ; Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Schmitt LR; Medical School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Boff R; Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil., Oppermann ML; Obstetrics Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Camargo JL; Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Silveiro SP; Postgraduate Program in Endocrinology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; Endocrine Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
المصدر: PloS one [PLoS One] 2016 Oct 20; Vol. 11 (10), pp. e0164999. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Diabetes, Gestational/*blood , Vitamin D/*analogs & derivatives , Vitamin D Deficiency/*complications, Adult ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Risk ; Vitamin D/blood
مستخلص: Background: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM.
Methods: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated.
Results: Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039requiring ICU, 15.3 vs 3.6%, P = 0.008), and were more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017). After adjustment, relative risk (RR) for hypoglycemia requiring ICU was 3.63 (95%CI 1.09-12.11) and for SGA was 4.32 (95%CI 1.75-10.66). The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups.
Conclusions: In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 1406-16-2 (Vitamin D)
A288AR3C9H (25-hydroxyvitamin D)
تواريخ الأحداث: Date Created: 20161021 Date Completed: 20170606 Latest Revision: 20220331
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5072629
DOI: 10.1371/journal.pone.0164999
PMID: 27764194
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0164999