دورية أكاديمية
أعرض في EDS

Factors predicting survival in ALS: a multicenter Italian study.

التفاصيل البيبلوغرافية
العنوان: Factors predicting survival in ALS: a multicenter Italian study.
المؤلفون: Calvo A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Torino, Turin, Italy., Moglia C; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Torino, Turin, Italy., Lunetta C; NEuroMuscular Omnicentre (NEMO), Serena Onlus Foundation, Milan, Italy.; NEMO Sud Clinical Center for Neuromuscular Diseases, Aurora Onlus Foundation, Messina, Italy., Marinou K; Department of Neurorehabilitation ALS Center Scientific Institute of Milan, Salvatore Maugeri Foundation IRCCS, Milan, Italy., Ticozzi N; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Pathophysiology and Transplantation 'Dino Ferrari' Center, University of Milan, Milan, Italy., Ferrante GD; Neurorehabilitation Unit/ALS Center, Salvatore Maugeri Foundation, IRCCS, Mistretta, Messina, Italy., Scialo C; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics Maternal and Child Health (DINOGMI), University of Genova, IRCCS AOU San Martino-IST, Genoa, Italy., Sorarù G; Department of Neurosciences Neuromuscular Center, University of Padova, Padua, Italy., Trojsi F; Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy., Conte A; NEuroMuscular Omnicentre (NEMO), Serena Onlus Foundation: Pol. A. Gemelli Foundation, Rome, Italy., Falzone YM; Department of Neurology Division of Neuroscience Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy., Tortelli R; Department of Clinical Research in Neurology, University of Bari 'A. Moro', at Pia Fondazione 'Card. G. Panico' Tricase, Lecce, Italy., Russo M; Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center for Neuromuscular Diseases, Aurora Foundation, Messina, Italy., Chiò A; 'Rita Levi Montalcini' Department of Neuroscience, ALS Center, University of Torino, Turin, Italy., Sansone VA; NEuroMuscular Omnicentre (NEMO), Serena Onlus Foundation, Milan, Italy.; Department Biomedical Sciences for Health, University of Milan, Milan, Italy., Mora G; Department of Neurorehabilitation ALS Center Scientific Institute of Milan, Salvatore Maugeri Foundation IRCCS, Milan, Italy., Silani V; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy.; Department of Pathophysiology and Transplantation 'Dino Ferrari' Center, University of Milan, Milan, Italy., Volanti P; Neurorehabilitation Unit/ALS Center, Salvatore Maugeri Foundation, IRCCS, Mistretta, Messina, Italy., Caponnetto C; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics Maternal and Child Health (DINOGMI), University of Genova, IRCCS AOU San Martino-IST, Genoa, Italy., Querin G; Department of Neurosciences Neuromuscular Center, University of Padova, Padua, Italy., Monsurrò MR; Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, MRI Research Center SUN-FISM, Second University of Naples, Naples, Italy., Sabatelli M; NEuroMuscular Omnicentre (NEMO), Serena Onlus Foundation: Pol. A. Gemelli Foundation, Rome, Italy.; Institute of Neurology, Catholic University of Sacred Heart, Rome, Italy., Riva N; Department of Neurology Division of Neuroscience Institute of Experimental Neurology, San Raffaele Scientific Institute, Milan, Italy., Logroscino G; Department of Clinical Research in Neurology, University of Bari 'A. Moro', at Pia Fondazione 'Card. G. Panico' Tricase, Lecce, Italy., Messina S; NEMO Sud Clinical Center for Neuromuscular Diseases, Aurora Onlus Foundation, Messina, Italy.; Department of Clinical and Experimental Medicine, University of Messina and Nemo Sud Clinical Center for Neuromuscular Diseases, Aurora Foundation, Messina, Italy., Fini N; Department of Neuroscience, S. Agostino-Estense Hospital and University of Modena and Reggio Emilia, Via Pietro Giardini n. 1355, 41100, Modena, Italy., Mandrioli J; Department of Neuroscience, S. Agostino-Estense Hospital and University of Modena and Reggio Emilia, Via Pietro Giardini n. 1355, 41100, Modena, Italy. j.mandrioli@ausl.mo.it.
المصدر: Journal of neurology [J Neurol] 2017 Jan; Vol. 264 (1), pp. 54-63. Date of Electronic Publication: 2016 Oct 24.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin ; New York, Springer-Verlag
مواضيع طبية MeSH: Amyotrophic Lateral Sclerosis/*diagnosis , Amyotrophic Lateral Sclerosis/*epidemiology, Age of Onset ; Aged ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/therapy ; Body Mass Index ; Delayed Diagnosis ; Female ; Follow-Up Studies ; Humans ; Italy/epidemiology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Phenotype ; Prognosis ; Retrospective Studies ; Tertiary Care Centers
مستخلص: The aim of this multicenter, retrospective study is to investigate the role of clinical characteristics and therapeutic intervention on ALS prognosis. The study included patients diagnosed from January 1, 2009 to December 31, 2013 in 13 Italian referral centers for ALS located in 10 Italian regions. Caring neurologists collected a detailed phenotypic profile and follow-up data until death into an electronic database. One center collected also data from a population-based registry for ALS. 2648 incident cases were collected. The median survival time from onset to death/tracheostomy was 44 months (SE 1.18, CI 42-46). According to univariate analysis, factors related to survival from onset to death/tracheostomy were: age at onset, diagnostic delay, site of onset, phenotype, degree of certainty at diagnosis according to revised El Escorial criteria (R-EEC), presence/absence of dementia, BMI at diagnosis, patients' provenance. In the multivariate analysis, age at onset, diagnostic delay, phenotypes but not site of onset, presence/absence of dementia, BMI, riluzole use, R-EEC criteria were independent prognostic factors of survival in ALS. We compared patients from an ALS Registry with patients from tertiary centers; the latter ones were younger, less frequently bulbar, but more frequently familial and definite at diagnosis. Our large, multicenter study demonstrated the role of some clinical and demographic factors on ALS survival, and showed some interesting differences between referral centers' patients and the general ALS population. These results can be helpful for clinical practice, in clinical trial design and to validate new tools to predict disease progression.
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فهرسة مساهمة: Keywords: ALS; Population-based registries; Prognostic factors; Referral centers; Survival
تواريخ الأحداث: Date Created: 20161026 Date Completed: 20170410 Latest Revision: 20220408
رمز التحديث: 20231215
DOI: 10.1007/s00415-016-8313-y
PMID: 27778156
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-1459
DOI:10.1007/s00415-016-8313-y