دورية أكاديمية
An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.
العنوان: | An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer. |
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المؤلفون: | Kedage V; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Selvaraj N; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Nicholas TR; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Budka JA; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Plotnik JP; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Jerde TJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA. Electronic address: pchollen@indiana.edu. |
المصدر: | Cell reports [Cell Rep] 2016 Oct 25; Vol. 17 (5), pp. 1289-1301. |
نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
مواضيع طبية MeSH: | Oncogenes*, Gene Rearrangement/*genetics , Prostatic Neoplasms/*genetics , Prostatic Neoplasms/*pathology , Proto-Oncogene Protein c-ets-1/*metabolism , RNA-Binding Protein EWS/*metabolism , Sarcoma, Ewing/*pathology, Animals ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Nude ; Phenotype ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; Transcription Factors/metabolism |
مستخلص: | More than 50% of prostate tumors have a chromosomal rearrangement resulting in aberrant expression of an oncogenic ETS family transcription factor. However, mechanisms that differentiate the function of oncogenic ETS factors expressed in prostate tumors from non-oncogenic ETS factors expressed in normal prostate are unknown. Here, we find that four oncogenic ETS (ERG, ETV1, ETV4, and ETV5), and no other ETS, interact with the Ewing's sarcoma breakpoint protein, EWS. This EWS interaction was necessary and sufficient for oncogenic ETS functions including gene activation, cell migration, clonogenic survival, and transformation. Significantly, the EWS interacting region of ERG has no homology with that of ETV1, ETV4, and ETV5. Therefore, this finding may explain how divergent ETS factors have a common oncogenic function. Strikingly, EWS is fused to various ETS factors by the chromosome translocations that cause Ewing's sarcoma. Therefore, these findings link oncogenic ETS function in both prostate cancer and Ewing's sarcoma. (Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.) |
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معلومات مُعتمدة: | K01 DK092366 United States DK NIDDK NIH HHS; P30 CA082709 United States CA NCI NIH HHS |
فهرسة مساهمة: | Keywords: ERG; ETS; EWS; Ewing’s sarcoma; prostate cancer |
المشرفين على المادة: | 0 (Proto-Oncogene Protein c-ets-1) 0 (RNA-Binding Protein EWS) 0 (Transcription Factors) |
تواريخ الأحداث: | Date Created: 20161027 Date Completed: 20171120 Latest Revision: 20181113 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5123826 |
DOI: | 10.1016/j.celrep.2016.10.001 |
PMID: | 27783944 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2211-1247 |
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DOI: | 10.1016/j.celrep.2016.10.001 |