دورية أكاديمية
أعرض في EDS

An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.

التفاصيل البيبلوغرافية
العنوان: An Interaction with Ewing's Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer.
المؤلفون: Kedage V; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA., Selvaraj N; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Nicholas TR; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Budka JA; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA., Plotnik JP; Department of Biology, Indiana University, Bloomington, IN 47405, USA., Jerde TJ; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Hollenhorst PC; Medical Sciences, Indiana University School of Medicine, Bloomington, IN 47405, USA. Electronic address: pchollen@indiana.edu.
المصدر: Cell reports [Cell Rep] 2016 Oct 25; Vol. 17 (5), pp. 1289-1301.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Oncogenes*, Gene Rearrangement/*genetics , Prostatic Neoplasms/*genetics , Prostatic Neoplasms/*pathology , Proto-Oncogene Protein c-ets-1/*metabolism , RNA-Binding Protein EWS/*metabolism , Sarcoma, Ewing/*pathology, Animals ; Carcinogenesis/pathology ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice, Nude ; Phenotype ; Promoter Regions, Genetic/genetics ; Protein Binding ; Protein Interaction Domains and Motifs ; Transcription Factors/metabolism
مستخلص: More than 50% of prostate tumors have a chromosomal rearrangement resulting in aberrant expression of an oncogenic ETS family transcription factor. However, mechanisms that differentiate the function of oncogenic ETS factors expressed in prostate tumors from non-oncogenic ETS factors expressed in normal prostate are unknown. Here, we find that four oncogenic ETS (ERG, ETV1, ETV4, and ETV5), and no other ETS, interact with the Ewing's sarcoma breakpoint protein, EWS. This EWS interaction was necessary and sufficient for oncogenic ETS functions including gene activation, cell migration, clonogenic survival, and transformation. Significantly, the EWS interacting region of ERG has no homology with that of ETV1, ETV4, and ETV5. Therefore, this finding may explain how divergent ETS factors have a common oncogenic function. Strikingly, EWS is fused to various ETS factors by the chromosome translocations that cause Ewing's sarcoma. Therefore, these findings link oncogenic ETS function in both prostate cancer and Ewing's sarcoma.
(Copyright © 2016 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: Genes Chromosomes Cancer. 2012 Mar;51(3):240-9. (PMID: 22081504)
J Biol Chem. 2000 Dec 1;275(48):37612-8. (PMID: 10982800)
Genes Dev. 2011 Oct 15;25(20):2147-57. (PMID: 22012618)
Stem Cells. 2005 Jun-Jul;23(6):738-51. (PMID: 15917470)
Cell Commun Signal. 2015 Feb 19;13:12. (PMID: 25885538)
Oncogene. 2001 Sep 10;20(40):5747-54. (PMID: 11607824)
Blood. 2011 Apr 7;117(14 ):3858-68. (PMID: 21321361)
Nucleic Acids Res. 2014 Oct 29;42(19):11928-40. (PMID: 25294825)
Nat Genet. 2009 May;41(5):619-24. (PMID: 19396168)
Nature. 2010 Oct 14;467(7317):849-53. (PMID: 20927104)
Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):E3506-15. (PMID: 23918374)
Nat Genet. 2009 May;41(5):524-6. (PMID: 19396167)
Cell. 2015 Nov 5;163(4):1011-25. (PMID: 26544944)
Cell Rep. 2014 May 22;7(4):1211-26. (PMID: 24813895)
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10149-54. (PMID: 18626011)
Mol Cancer. 2014 Mar 19;13:61. (PMID: 24642271)
Dev Cell. 2013 Aug 26;26(4):393-404. (PMID: 23987512)
Mol Cell Biol. 1993 Dec;13(12):7393-8. (PMID: 8246959)
Cancer Discov. 2011 Jun;1(1):35-43. (PMID: 22140652)
J Biol Chem. 2003 Feb 14;278(7):5427-32. (PMID: 12459554)
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12465-70. (PMID: 19592505)
Neoplasia. 2008 Feb;10 (2):177-88. (PMID: 18283340)
Genes Cancer. 2011 Jan 1;1(10):1044-1052. (PMID: 21373373)
J Pathol. 2005 Dec;207(4):422-9. (PMID: 16175655)
Cancer Res. 2009 Apr 1;69(7):2734-8. (PMID: 19293179)
Mol Cell Biol. 1998 Mar;18(3):1489-97. (PMID: 9488465)
Cell Cycle. 2012 Sep 15;11(18):3380-3. (PMID: 22918253)
Genome Res. 2012 Feb;22(2):259-70. (PMID: 22086061)
Cancer Res. 2013 Oct 1;73(19):6068-79. (PMID: 23913826)
Cancer Cell. 2010 May 18;17 (5):443-54. (PMID: 20478527)
Differentiation. 2010 Jan;79(1):41-7. (PMID: 19773112)
J Proteome Res. 2009 Oct;8(10 ):4455-65. (PMID: 19673543)
Mol Cell. 2011 Aug 5;43(3):353-68. (PMID: 21816343)
Nature. 2007 Aug 2;448(7153):595-9. (PMID: 17671502)
Cell. 2015 May 21;161(5):1215-28. (PMID: 26000489)
Lab Invest. 2011 Mar;91(3):404-12. (PMID: 20975660)
Genes Dev. 2013 Mar 15;27(6):683-98. (PMID: 23512661)
Cancer Res. 2010 Mar 1;70(5):2075-84. (PMID: 20160028)
Annu Rev Biochem. 2011;80:437-71. (PMID: 21548782)
J Mol Cell Biol. 2009 Dec;1(2):82-92. (PMID: 19783543)
Nucleic Acids Res. 2004 Oct 21;32(18):5693-702. (PMID: 15498926)
Oncogene. 2007 Apr 19;26(18):2667-73. (PMID: 17043636)
Cancer Cell. 2014 Nov 10;26(5):668-81. (PMID: 25453903)
EMBO J. 2012 Jun 13;31(12):2810-23. (PMID: 22531786)
Cancer Res. 2001 May 1;61(9):3586-90. (PMID: 11325824)
Nature. 1992 Sep 10;359(6391):162-5. (PMID: 1522903)
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1307-16. (PMID: 25737553)
Science. 2005 Oct 28;310(5748):644-8. (PMID: 16254181)
J Biol Chem. 1998 Oct 23;273(43):27761-4. (PMID: 9774382)
Cancer Res. 2002 Oct 1;62(19):5408-12. (PMID: 12359745)
Dev Biol. 2014 Oct 1;394(1):181-90. (PMID: 25109552)
Biochim Biophys Acta. 2012 Aug;1826(1):1-12. (PMID: 22425584)
معلومات مُعتمدة: K01 DK092366 United States DK NIDDK NIH HHS; P30 CA082709 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: ERG; ETS; EWS; Ewing’s sarcoma; prostate cancer
المشرفين على المادة: 0 (Proto-Oncogene Protein c-ets-1)
0 (RNA-Binding Protein EWS)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20161027 Date Completed: 20171120 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5123826
DOI: 10.1016/j.celrep.2016.10.001
PMID: 27783944
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2016.10.001