دورية أكاديمية
Nephroprotective effects of remote ischemic preconditioning in coronary angiography.
| العنوان: | Nephroprotective effects of remote ischemic preconditioning in coronary angiography. |
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| المؤلفون: | Zagidullin NS; Department of Internal Diseases, Bashkir State Medical University, Ufa, Russian Federation., Dunayeva AR; Department of Internal Diseases, Bashkir State Medical University, Ufa, Russian Federation., Plechev VV; Department of Surgery, Bashkir State Medical University, Ufa, Russian Federation., Gilmanov AZ; Department of Laboratory Diagnostics, Bashkir State Medical University, Ufa, Russian Federation., Zagidullin SZ; Department of Internal Diseases, Bashkir State Medical University, Ufa, Russian Federation., Er F; Department of Internal Diseases, Klinikum Gütersloh, Department of Cardiology and Electrophysiology, Gutersloch, Germany., Pavlov VN; Department of Urology, Bashkir State Medical University, Ufa, Russian Federation. |
| المصدر: | Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2017; Vol. 65 (3), pp. 299-307. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Ios Press Country of Publication: Netherlands NLM ID: 9709206 Publication Model: Print Cited Medium: Internet ISSN: 1875-8622 (Electronic) Linking ISSN: 13860291 NLM ISO Abbreviation: Clin Hemorheol Microcirc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Ios Press Original Publication: Amsterdam ; Washington, DC : IOS Press, c1997- |
| مواضيع طبية MeSH: | Acute Kidney Injury/*etiology , Coronary Angiography/*adverse effects , Ischemic Preconditioning/*methods, Acute Kidney Injury/pathology ; Coronary Angiography/methods ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies |
| مستخلص: | Background: Contrast-induced nephropathy (CIN) is a formidable side effect of iodinated contrast medium use in subjects undergoing coronary angiogram (CAG). Remote ischemic preconditioning (RIPC) may reduce the risk of CIN. Aim: The aim of the study was to investigate the nephroprotective effects of RIPC in coronary heart disease (CHD) in patients, undergoing CAG, with mild to moderate lowered estimated glomerular filtration rate (eGFR). Materials: In the randomized, blinded, sham RIPC (sRIPC) controlled study 51 patients with CHD and GFR less than 80 mL/min/m2, undergoing CAG, were investigated. The patients were randomized for RIPC (n = 26, 60.5±2.0 years) or sRIPC (n = 25, 62.96±1.7). RIPC was performed before the CAG by means of 3-5-minute cycle cuff pumped on the upper arm + 50 mm Hg above the systolic blood pressure (BP), while in sRIPC it corresponded to diastolic BP. The primary endpoint was the development of CIN and secondary - change of biomarkers (creatinine, urea, neutrophil gelatinase-associated lipocalin (NGAL), cystatin-C). Results: In RIPC group, CIN occurred in 28% of cases, while in sRIPC - 3.8%. All investigated markers increased in sRIPC and declined in RIPC; the difference was significant in markers between the groups before and after CAG. Conclusions: RIPC proved nephroprotective effect in prevention of contrast-induced nephropathy in CHD subjects with mild to moderate lowered eGFR. |
| فهرسة مساهمة: | Keywords: CIN; NGAL; RIPC; cystatin |
| تواريخ الأحداث: | Date Created: 20161105 Date Completed: 20170512 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3233/CH-16184 |
| PMID: | 27814282 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-8622 |
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| DOI: | 10.3233/CH-16184 |