دورية أكاديمية
Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort.
| العنوان: | Vitamin D supplementation, cord 25-hydroxyvitamin D and birth weight: Findings from the Odense Child Cohort. |
|---|---|
| المؤلفون: | Lykkedegn S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Beck-Nielsen SS; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Sorensen GL; Institute of Molecular Medicine, Department of Cancer and Inflammation, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Andersen LB; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Fruekilde PBN; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark., Nielsen J; Research Unit of Clinical Epidemiology, Institute of Clinical Research, University of Southern Denmark, Region Southern Denmark, Denmark., Kyhl HB; Odense Child Cohort, Hans Christian Andersen Children's Hospital, Odense, Denmark; Odense Patient data Explorative Network (OPEN), Denmark., Joergensen JS; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark., Husby S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Christesen HT; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark; Clinical Institute, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. Electronic address: henrik.christesen@rsyd.dk. |
| المصدر: | Clinical nutrition (Edinburgh, Scotland) [Clin Nutr] 2017 Dec; Vol. 36 (6), pp. 1621-1627. Date of Electronic Publication: 2016 Oct 27. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8309603 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1983 (Electronic) Linking ISSN: 02615614 NLM ISO Abbreviation: Clin Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004->: Kidlington, Oxford, U.K. : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1982- |
| مواضيع طبية MeSH: | Birth Weight* , Dietary Supplements*, Vitamin D/*administration & dosage , Vitamin D Deficiency/*epidemiology, Adolescent ; Adult ; Body Mass Index ; Denmark/epidemiology ; Female ; Fetal Blood/chemistry ; Humans ; Male ; Maternal Nutritional Physiological Phenomena ; Prevalence ; Prospective Studies ; Risk Factors ; Seasons ; Treatment Outcome ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Young Adult |
| مستخلص: | Background & Aims: Hypovitaminosis D, defined as serum 25-hydroxyvitamin D (s-25(OH)D) <50 nmol/L, is frequent in pregnant women and neonates worldwide and has been associated with both low birth weight (BW) and placental weight (PW) as well as reduced placental development. We aimed to assess the prevalence and the risk factors of cord vitamin D deficiency (s-25(OH)D <25 nmol/L) and insufficiency (s-25(OH)D 25-50 nmol/L) and to evaluate the association between cord s-25(OH)D levels and neonatal outcomes (BW, PW and PW/BW ratio). Methods: Women enrolled in Odense Child Cohort, a Danish observational prospective population-based cohort, who gave birth to singletons and donated a blood sample for s-25(OH)D measurements were included (n = 2082). Results: The prevalence of cord vitamin D deficiency was 16.7% and 41.0% for insufficiency. White skin, winter season at birth, maternal supplementation dose of <15 μg/day, non-western ethnicity and high body mass index (BMI) were identified as independent risk factors of both vitamin D deficiency and insufficiency. Adherence to the recommended vitamin D supplementation dose (10 μg/day) was reported by 87% (primipara 91% vs. multipara 81%, p < 0.0001). An U-shaped relationship between cord s-25(OH)D and BW was visualized by spline regression (p = 0.003). After adjustment, cord s-25(OH)D was positively associated with BW (β = 1.522, p = 0.026), PW (β = 0.927, p < 0.001) and PW/BW ratio (β = 0.018, p < 0.001), largely driven by positive associations for cord s-25(OH)D >60 nmol/L. Conclusion: Cord hypovitaminosis D was present in 57.7%. Multipara was identified as a novel risk factor of non-adherence to vitamin D supplementation recommendations; and a maternal supplementation dose <15 μg/day as a novel, independent risk factor of cord hypovitaminosis D. Higher BW, PW, and PW/BW ratio were associated to higher cord s-25(OH)D levels with a suggested cut-off at 60 nmol/L. More studies are encouraged to elucidate the impact of cord s-25(OH)D levels on offspring health and to establish optimal cut-offs for these outcomes. (Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Birth weight; Supplementation; Vitamin D |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20161108 Date Completed: 20180717 Latest Revision: 20220316 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clnu.2016.10.008 |
| PMID: | 27817876 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1983 |
|---|---|
| DOI: | 10.1016/j.clnu.2016.10.008 |