دورية أكاديمية
Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.
العنوان: | Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections. |
---|---|
المؤلفون: | Madsen EC; 1Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Boston, MA. 2Division of Critical Care Medicine, Department of Pediatrics, Duke University, Durham, NC. 3Department of Anesthesia, Harvard Medical School, Boston, MA. 4Department of Pediatrics, Harvard Medical School, Boston, MA. 5Department of Pediatrics, Center for Patient Safety and Quality Research, Boston Children's Hospital, Boston, MA., Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG |
المصدر: | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2017 Feb; Vol. 18 (2), pp. 103-111. |
نوع المنشور: | Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Baltimore, MD : Lippincott Williams & Wilkins, c2000- |
مواضيع طبية MeSH: | Haplotypes* , Immunity, Innate* , Polymorphism, Single Nucleotide*, Mannose-Binding Lectin/*blood , Sepsis/*immunology, Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Critical Illness ; Female ; Genetic Markers ; Genotyping Techniques ; Humans ; Infant ; Infant, Newborn ; Male ; Mannose-Binding Lectin/genetics ; Prospective Studies ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/genetics ; Severity of Illness Index ; Young Adult |
مستخلص: | Objectives: Low mannose-binding lectin levels and haplotypes associated with low mannose-binding lectin production have been associated with infection and severe sepsis. We tested the hypothesis that mannose-binding lectin levels would be associated with severe infection in a large cohort of critically ill children. Design: Prospective cohort study. Setting: Medical and Surgical PICUs, Boston Children's Hospital. Patients: Children less than 21 years old admitted to the ICUs from November 2009 to November 2010. Interventions: None. Measurements and Main Results: We measured mannose-binding lectin levels in 479 of 520 consecutively admitted children (92%) with severe or life-threatening illness. We genotyped 213 Caucasian children for mannose-binding lectin haplotype tagging variants and assigned haplotypes. In the univariate analyses of mannose-binding lectin levels with preadmission characteristics, levels were higher in patients with preexisting renal disease. Patients who received greater than 100 mL/kg of fluids in the first 24 hours after admission had markedly lower mannose-binding lectin, as did patients who underwent spinal fusion surgery. Mannose-binding lectin levels had no association with infection status at admission, or with progression from systemic inflammatory response syndrome to sepsis or septic shock. Although mannose-binding lectin haplotypes strongly influenced mannose-binding lectin levels in the predicted relationship, low mannose-binding lectin-producing haplotypes were not associated with increased risk of infection. Conclusions: Mannose-binding lectin levels are largely genetically determined. This relationship was preserved in children during critical illness, despite the effect of large-volume fluid administration on mannose-binding lectin levels. Previous literature evaluating an association between mannose-binding lectin levels and severe infection is inconsistent; we found no relationship in our PICU cohort. We found that mannose-binding lectin levels were lower after aggressive fluid resuscitation and suggest that studies of mannose-binding lectin in critically ill patients should assess mannose-binding lectin haplotypes to reflect preillness levels. |
التعليقات: | Comment in: Pediatr Crit Care Med. 2017 Feb;18(2):190-191. (PMID: 28157794) |
References: | Scand J Immunol. 2004 Dec;60(6):615-24. (PMID: 15584973) Scand J Immunol. 2004 Jan;59(1):97-102. (PMID: 14723627) Transfus Med. 2002 Dec;12(6):335-52. (PMID: 12473150) Hum Mol Genet. 2007 Dec 15;16(24):3071-80. (PMID: 17872904) Crit Care. 2014 Jun 20;18(3):R127. (PMID: 24950659) Eur J Cancer. 2006 May;42(7):909-16. (PMID: 16517152) Transpl Int. 2008 Jan;21(1):57-64. (PMID: 17883369) Epidemiol Infect. 2014 Oct;142(10):2195-206. (PMID: 24398289) Clin Vaccine Immunol. 2008 Jan;15(1):65-70. (PMID: 17978009) Inflammation. 2015 Feb;38(1):338-47. (PMID: 25323207) J Infect Dis. 2012 Jan 1;205(1):44-53. (PMID: 22080095) Pediatr Crit Care Med. 2010 Sep;11(5):561-7. (PMID: 20351616) Clin Infect Dis. 2009 Nov 1;49(9):1380-6. (PMID: 19793001) J Immunol. 1995 Sep 15;155(6):3013-20. (PMID: 7673719) Crit Care. 2008;12(6):R161. (PMID: 19091120) Clin Infect Dis. 2008 Aug 15;47(4):510-6. (PMID: 18611155) Immunol Rev. 2004 Apr;198:185-202. (PMID: 15199963) Pediatr Blood Cancer. 2011 Jul 15;57(1):89-96. (PMID: 21557458) Pediatrics. 2012 Sep;130(3):421-8. (PMID: 22869836) Intensive Care Med. 2004 Jul;30(7):1438-45. (PMID: 15127191) Mol Immunol. 2006 May;43(13):2051-60. (PMID: 16499969) Transfusion. 2008 Apr;48(4):601-8. (PMID: 18194386) J Infect Dis. 2003 Nov 1;188(9):1394-403. (PMID: 14593599) Br J Surg. 2013 Dec;100(13):1818-26. (PMID: 24227370) Crit Care Med. 1996 May;24(5):743-52. (PMID: 8706448) J Biochem. 1999 Dec;126(6):1004-12. (PMID: 10578050) APMIS. 2014 Feb;122(2):136-9. (PMID: 23755909) Crit Care. 2009;13(6):R176. (PMID: 19891773) Lancet. 2001 Aug 25;358(9282):637-8. (PMID: 11530153) Transplantation. 2011 May 15;91(9):1044-9. (PMID: 21394075) Clin Immunol. 2012 Jul;144(1):80-2. (PMID: 22673492) Mediators Inflamm. 2013;2013:625803. (PMID: 24223476) Hum Immunol. 2010 Nov;71(11):1084-8. (PMID: 20732365) Clin Infect Dis. 2015 Sep 1;61(5):695-703. (PMID: 25969530) Clin Exp Immunol. 2011 Jul;165(1):51-9. (PMID: 21488869) Pediatr Crit Care Med. 2005 Jan;6(1):2-8. (PMID: 15636651) Biochem Soc Trans. 2003 Aug;31(Pt 4):768-9. (PMID: 12887300) Scand J Immunol. 2002 Dec;56(6):630-41. (PMID: 12472676) Int J Clin Exp Pathol. 2015 Nov 01;8(11):15123-7. (PMID: 26823854) PLoS One. 2013 Sep 27;8(9):e76218. (PMID: 24086711) J Allergy Clin Immunol. 2008 Aug;122(2):368-74, 374.e1-2. (PMID: 18582923) Clin Infect Dis. 2011 Oct;53(7):e25-76. (PMID: 21880587) Eur J Cancer. 2009 Mar;45(4):505-12. (PMID: 19121580) Clin Exp Immunol. 2007 Nov;150(2):255-62. (PMID: 17711490) Clin Infect Dis. 2003 Dec 1;37(11):1496-505. (PMID: 14614673) Clin Vaccine Immunol. 2010 Mar;17(3):447-53. (PMID: 20042521) Eur J Haematol. 2006 Jun;76(6):481-7. (PMID: 16494622) Pediatr Res. 2007 Mar;61(3):325-8. (PMID: 17314691) J Pediatric Infect Dis Soc. 2013 Jun;2(2):155-61. (PMID: 26619462) FEMS Immunol Med Microbiol. 2006 Nov;48(2):274-82. (PMID: 17064281) Pediatr Res. 2014 Jan;75(1-1):99-108. (PMID: 24129551) Clin Microbiol Infect. 2014 Dec;20(12):1337-42. (PMID: 24977653) Transpl Immunol. 2012 Mar;26(2-3):123-7. (PMID: 22198424) Clin Infect Dis. 1999 Aug;29(2):414-9. (PMID: 10476751) Pediatrics. 2015 Jul;136(1):44-52. (PMID: 26101356) Shock. 2006 Jan;25(1):88-93. (PMID: 16369192) |
معلومات مُعتمدة: | R01 AI084011 United States AI NIAID NIH HHS; R56 AI084011 United States AI NIAID NIH HHS; UL1 RR025758 United States RR NCRR NIH HHS |
المشرفين على المادة: | 0 (Biomarkers) 0 (Genetic Markers) 0 (MBL2 protein, human) 0 (Mannose-Binding Lectin) |
تواريخ الأحداث: | Date Created: 20161108 Date Completed: 20171102 Latest Revision: 20181113 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5366242 |
DOI: | 10.1097/PCC.0000000000001000 |
PMID: | 27820718 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1529-7535 |
---|---|
DOI: | 10.1097/PCC.0000000000001000 |