دورية أكاديمية
أعرض في EDS

Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.

التفاصيل البيبلوغرافية
العنوان: Mannose-Binding Lectin Levels in Critically Ill Children With Severe Infections.
المؤلفون: Madsen EC; 1Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Boston, MA. 2Division of Critical Care Medicine, Department of Pediatrics, Duke University, Durham, NC. 3Department of Anesthesia, Harvard Medical School, Boston, MA. 4Department of Pediatrics, Harvard Medical School, Boston, MA. 5Department of Pediatrics, Center for Patient Safety and Quality Research, Boston Children's Hospital, Boston, MA., Levy ER, Madden K, Agan AA, Sullivan RM, Graham DA, Randolph AG
المصدر: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2017 Feb; Vol. 18 (2), pp. 103-111.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Baltimore, MD : Lippincott Williams & Wilkins, c2000-
مواضيع طبية MeSH: Haplotypes* , Immunity, Innate* , Polymorphism, Single Nucleotide*, Mannose-Binding Lectin/*blood , Sepsis/*immunology, Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Critical Illness ; Female ; Genetic Markers ; Genotyping Techniques ; Humans ; Infant ; Infant, Newborn ; Male ; Mannose-Binding Lectin/genetics ; Prospective Studies ; Sepsis/blood ; Sepsis/diagnosis ; Sepsis/genetics ; Severity of Illness Index ; Young Adult
مستخلص: Objectives: Low mannose-binding lectin levels and haplotypes associated with low mannose-binding lectin production have been associated with infection and severe sepsis. We tested the hypothesis that mannose-binding lectin levels would be associated with severe infection in a large cohort of critically ill children.
Design: Prospective cohort study.
Setting: Medical and Surgical PICUs, Boston Children's Hospital.
Patients: Children less than 21 years old admitted to the ICUs from November 2009 to November 2010.
Interventions: None.
Measurements and Main Results: We measured mannose-binding lectin levels in 479 of 520 consecutively admitted children (92%) with severe or life-threatening illness. We genotyped 213 Caucasian children for mannose-binding lectin haplotype tagging variants and assigned haplotypes. In the univariate analyses of mannose-binding lectin levels with preadmission characteristics, levels were higher in patients with preexisting renal disease. Patients who received greater than 100 mL/kg of fluids in the first 24 hours after admission had markedly lower mannose-binding lectin, as did patients who underwent spinal fusion surgery. Mannose-binding lectin levels had no association with infection status at admission, or with progression from systemic inflammatory response syndrome to sepsis or septic shock. Although mannose-binding lectin haplotypes strongly influenced mannose-binding lectin levels in the predicted relationship, low mannose-binding lectin-producing haplotypes were not associated with increased risk of infection.
Conclusions: Mannose-binding lectin levels are largely genetically determined. This relationship was preserved in children during critical illness, despite the effect of large-volume fluid administration on mannose-binding lectin levels. Previous literature evaluating an association between mannose-binding lectin levels and severe infection is inconsistent; we found no relationship in our PICU cohort. We found that mannose-binding lectin levels were lower after aggressive fluid resuscitation and suggest that studies of mannose-binding lectin in critically ill patients should assess mannose-binding lectin haplotypes to reflect preillness levels.
التعليقات: Comment in: Pediatr Crit Care Med. 2017 Feb;18(2):190-191. (PMID: 28157794)
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معلومات مُعتمدة: R01 AI084011 United States AI NIAID NIH HHS; R56 AI084011 United States AI NIAID NIH HHS; UL1 RR025758 United States RR NCRR NIH HHS
المشرفين على المادة: 0 (Biomarkers)
0 (Genetic Markers)
0 (MBL2 protein, human)
0 (Mannose-Binding Lectin)
تواريخ الأحداث: Date Created: 20161108 Date Completed: 20171102 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5366242
DOI: 10.1097/PCC.0000000000001000
PMID: 27820718
قاعدة البيانات: MEDLINE
الوصف
تدمد:1529-7535
DOI:10.1097/PCC.0000000000001000