دورية أكاديمية
Insulin-like peptide DILP6 regulates juvenile hormone and dopamine metabolism in Drosophila females.
| العنوان: | Insulin-like peptide DILP6 regulates juvenile hormone and dopamine metabolism in Drosophila females. |
|---|---|
| المؤلفون: | Rauschenbach IY; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Karpova EK; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Burdina EV; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Adonyeva NV; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Bykov RA; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Ilinsky YY; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Menshanov PN; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia., Gruntenko NE; Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia. Electronic address: nataly@bionet.nsc.ru. |
| المصدر: | General and comparative endocrinology [Gen Comp Endocrinol] 2017 Mar 01; Vol. 243, pp. 1-9. Date of Electronic Publication: 2016 Nov 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6840 (Electronic) Linking ISSN: 00166480 NLM ISO Abbreviation: Gen Comp Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Dopamine/*metabolism , Drosophila Proteins/*metabolism , Drosophila melanogaster/*metabolism , Juvenile Hormones/*metabolism , Reproduction/*physiology , Somatomedins/*metabolism, Animals ; Female ; Signal Transduction |
| مستخلص: | Insulin-like peptide DILP6 is a component of the insulin/insulin-like growth factor signalling pathway of Drosophila. Juvenile hormone (JH) and dopamine (DA) are involved in the stress response and in the control of reproduction. In this study, we investigate whether DILP6 regulates the JH and DA levels by studying the effect of a strong hypomorphic mutation dilp6 41 on JH and DA metabolism in D. melanogaster females. We show that DILP6 regulates JH and DA metabolism: the mutation dilp6 41 results in a reduction in JH-hydrolysing activity and an increase in the activities of DA synthesis enzymes (alkaline phosphatase (ALP) and tyrosine hydroxylase (TH)). In the mutant females, we also found increased fecundity in addition to the intensity of the response (stress reactivity) of ALP and TH to heat stress. As we showed previously, this suggests an increased level of JH synthesis. We confirm this suggestion by treating the mutant females with the JH inhibitor, precocene, which restors the activity and stress reactivity of ALP and TH as well as fecundity to levels similar to those in the control flies. The data suggest a feedback system in the interaction between JH and DILP6 in which DILP6 negatively regulates the JH titre via an increase in the hormone degradation and a decrease in its synthesis. (Copyright © 2016 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dopamine; Drosophila; Fecundity; Heat stress; Insulin-like peptides; Juvenile hormone |
| المشرفين على المادة: | 0 (Drosophila Proteins) 0 (Ilp6 protein, Drosophila) 0 (Juvenile Hormones) 0 (Somatomedins) VTD58H1Z2X (Dopamine) |
| تواريخ الأحداث: | Date Created: 20161109 Date Completed: 20170928 Latest Revision: 20190617 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ygcen.2016.11.004 |
| PMID: | 27823956 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1095-6840 |
|---|---|
| DOI: | 10.1016/j.ygcen.2016.11.004 |