دورية أكاديمية
Enhancing Stent Effectiveness with Nanofeatures.
| العنوان: | Enhancing Stent Effectiveness with Nanofeatures. |
|---|---|
| المؤلفون: | Bassous N; Northeastern University, Boston, Massachusetts., Cooke JP; Houston Methodist Research Institute, Houston, Texas., Webster TJ; Northeastern University, Boston, Massachusetts. |
| المصدر: | Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2016 Sep; Vol. 12 (3), pp. 163-168. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Methodist DeBakey Heart & Vascular Center Country of Publication: United States NLM ID: 101508600 Publication Model: Print Cited Medium: Internet ISSN: 1947-6108 (Electronic) Linking ISSN: 19476108 NLM ISO Abbreviation: Methodist Debakey Cardiovasc J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Houston, TX : Methodist DeBakey Heart & Vascular Center |
| مواضيع طبية MeSH: | Drug-Eluting Stents* , Nanoparticles*, Coronary Occlusion/*surgery , Coronary Restenosis/*prevention & control, Humans |
| مستخلص: | Drug-eluting stents are an effective therapy for symptomatic arterial obstructions, substantially reducing the incidence of restenosis by suppressing the migration and proliferation of vascular smooth muscle cells into the intima. However, current drug-eluting stents also inhibit the growth of endothelial cells, which are required to cover the vascular stent to reduce an excessive inflammatory response. As a result, the endothelial lining of the lumen is not regenerated. Since the loss of this homeostatic monolayer increases the risk of thrombosis, patients with drug-eluting stents require long-term antithrombotic therapy. Thus, there is a need for improved devices with enhanced effectiveness and physiological compatibility towards endothelial cells. Current developments in nanomaterials may enhance the function of commercially available vascular devices. In particular, modified design schemes might incorporate nanopatterns or nanoparticle-eluting features that reduce restenosis and enhance re-endothelialization. The intent of this review is to discuss emerging nanotechnologies that will improve the performance of vascular stents. |
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| معلومات مُعتمدة: | U01 HL100397 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: bare-metal stents; drug-eluting stents; nanoparticle-eluting stents; nanopatterning; nanotechnology |
| تواريخ الأحداث: | Date Created: 20161110 Date Completed: 20170509 Latest Revision: 20240326 |
| رمز التحديث: | 20240326 |
| مُعرف محوري في PubMed: | PMC5098574 |
| DOI: | 10.14797/mdcj-12-3-163 |
| PMID: | 27826371 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1947-6108 |
|---|---|
| DOI: | 10.14797/mdcj-12-3-163 |