دورية أكاديمية
Topical application of tranexamic acid in anticoagulated patients undergoing minor oral surgery: A systematic review and meta-analysis of randomized clinical trials.
| العنوان: | Topical application of tranexamic acid in anticoagulated patients undergoing minor oral surgery: A systematic review and meta-analysis of randomized clinical trials. |
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| المؤلفون: | de Vasconcellos SJ; Universidade Federal de Sergipe, Sergipe, Brazil., de Santana Santos T; Universidade Federal de Sergipe, Sergipe, Brazil., Reinheimer DM; Universidade Federal de Sergipe, Sergipe, Brazil., Faria-E-Silva AL; Universidade Federal de Sergipe, Sergipe, Brazil., de Melo MF; Universidade Federal de Sergipe, Sergipe, Brazil., Martins-Filho PR; Universidade Federal de Sergipe, Sergipe, Brazil. Electronic address: martins-filho@ufs.br. |
| المصدر: | Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery [J Craniomaxillofac Surg] 2017 Jan; Vol. 45 (1), pp. 20-26. Date of Electronic Publication: 2016 Oct 13. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Scotland NLM ID: 8704309 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4119 (Electronic) Linking ISSN: 10105182 NLM ISO Abbreviation: J Craniomaxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Edinburgh : Elsevier Original Publication: Stuttgart ; New York : Thieme, [c1986- |
| مواضيع طبية MeSH: | Anticoagulants/*adverse effects , Antifibrinolytic Agents/*therapeutic use , Oral Surgical Procedures/*methods , Postoperative Hemorrhage/*prevention & control , Tranexamic Acid/*therapeutic use, Administration, Topical ; Antifibrinolytic Agents/administration & dosage ; Humans ; Oral Surgical Procedures/adverse effects ; Tranexamic Acid/administration & dosage |
| مستخلص: | Purpose: To perform a systematic review and meta-analysis of randomized clinical trials (RCTs) investigating the efficacy and safety of topical tranexamic acid (TXA) to prevent postoperative bleeding in anticoagulated patients undergoing minor oral surgery. Material and Methods: We analyzed RCTs comparing the use of topical TXA versus other topical hemostatic agents or placebo solutions for minor oral surgeries. We assessed the risk of bias and strength of evidence according to the Cochrane guidelines and GRADE rating system, respectively. The pooled relative risk (RR) was calculated for the effect of topical application of TXA on postsurgical bleeding. Results: Five RCTs were included in the study. The combined RR for the number of patients receiving TXA in comparison to the control group was 0.13 (95% CI 0.05-0.36; P = 0.01), indicating a protective effect of topical TXA on bleeding after minor oral surgeries. Subgroup analysis revealed that topical TXA was effective in preventing postsurgical bleeding compared to placebo and epsilon-aminocaproic acid. No cases of thromboembolic events were reported. Conclusions: Currently available evidence suggests that surgical site irrigation with TXA followed by mouthwash during the first postoperative week is safe and may reduce the risk of bleeding after minor oral surgeries in anticoagulated patients. (Copyright © 2016. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Evidence-based dentistry; Hemorrhage; Oral surgical procedures; Tranexamic acid |
| المشرفين على المادة: | 0 (Anticoagulants) 0 (Antifibrinolytic Agents) 6T84R30KC1 (Tranexamic Acid) |
| تواريخ الأحداث: | Date Created: 20161115 Date Completed: 20171212 Latest Revision: 20181202 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jcms.2016.10.001 |
| PMID: | 27840121 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1878-4119 |
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| DOI: | 10.1016/j.jcms.2016.10.001 |