دورية أكاديمية
أعرض في EDS

An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.

التفاصيل البيبلوغرافية
العنوان: An expanding toolkit for preclinical pre-erythrocytic malaria vaccine development: bridging traditional mouse malaria models and human trials.
المؤلفون: Steel RW; Center for Infectious Disease Research, Formerly Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA., Kappe SH; Center for Infectious Disease Research, Formerly Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA., Sack BK; Center for Infectious Disease Research, Formerly Seattle Biomedical Research Institute, 307 Westlake Avenue North, Suite 500, Seattle, WA 98109, USA.
المصدر: Future microbiology [Future Microbiol] 2016 Dec; Vol. 11, pp. 1563-1579. Date of Electronic Publication: 2016 Nov 18.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101278120 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1746-0921 (Electronic) Linking ISSN: 17460913 NLM ISO Abbreviation: Future Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine
مواضيع طبية MeSH: Erythrocytes/*immunology , Malaria/*prevention & control , Malaria Vaccines/*immunology, Animals ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Erythrocytes/parasitology ; Humans ; Malaria/immunology ; Malaria/parasitology ; Malaria/transmission ; Malaria Vaccines/administration & dosage ; Malaria Vaccines/genetics ; Mice ; Plasmodium/genetics ; Plasmodium/immunology ; Translational Research, Biomedical
مستخلص: Malaria remains a significant public health burden with 214 million new infections and over 400,000 deaths in 2015. Elucidating relevant Plasmodium parasite biology can lead to the identification of novel ways to control and ultimately eliminate the parasite within geographic areas. Particularly, the development of an effective vaccine that targets the clinically silent pre-erythrocytic stages of infection would significantly augment existing malaria elimination tools by preventing both the onset of blood-stage infection/disease as well as spread of the parasite through mosquito transmission. In this Perspective, we discuss the role of small animal models in pre-erythrocytic stage vaccine development, highlighting how human liver-chimeric and human immune system mice are emerging as valuable components of these efforts.
Competing Interests: Financial & competing interests disclosure Work by the authors is funded by the National Institute of Allergy and Infectious Diseases (NIAID) (grant numbers NIH 5 F32 AI114113-03 and R01AI117234), the Malaria Vaccine Initiative (MVI), the Bill & Melinda Gates Foundation (BMGF) and the US Department of Defense (DoD). The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding institutions. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
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معلومات مُعتمدة: F32 AI114113 United States AI NIAID NIH HHS; R01 AI117234 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Plasmodium; antigen identification; cellular and humoral immunity; human immune system mice; human liver-chimeric mice; in vitro assays; malaria; pre-erythrocytic vaccine; whole-sporozoite immunization
المشرفين على المادة: 0 (Malaria Vaccines)
تواريخ الأحداث: Date Created: 20161119 Date Completed: 20170707 Latest Revision: 20211204
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5131654
DOI: 10.2217/fmb-2016-0077
PMID: 27855488
قاعدة البيانات: MEDLINE
الوصف
تدمد:1746-0921
DOI:10.2217/fmb-2016-0077