دورية أكاديمية
أعرض في EDS

Waterborne aripiprazole blunts the stress response in zebrafish.

التفاصيل البيبلوغرافية
العنوان: Waterborne aripiprazole blunts the stress response in zebrafish.
المؤلفون: Barcellos HH; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., Kalichak F; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil., da Rosa JG; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil., Oliveira TA; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil., Koakoski G; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil., Idalencio R; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., de Abreu MS; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil., Giacomini AC; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., Fagundes M; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., Variani C; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., Rossini M; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil., Piato AL; Programa de Pós-Graduação em Farmacologia e Terapêutica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90050-170, Brasil., Barcellos LJ; Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria (UFSM), Av. Roraima, 1000, Cidade Universitária, Camobi, Santa Maria, RS, 97105-900, Brazil.; Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.; Programa de Pós-Graduação em Bioexperimentação, Universidade de Passo Fundo (UPF), BR 285, São José, Passo Fundo, RS, 99052-900, Brazil.
المصدر: Scientific reports [Sci Rep] 2016 Nov 22; Vol. 6, pp. 37612. Date of Electronic Publication: 2016 Nov 22.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Aripiprazole/*toxicity , Stress, Physiological/*drug effects , Water Pollutants, Chemical/*toxicity , Zebrafish/*physiology, Animals ; Female ; Hydrocortisone/metabolism ; Male
مستخلص: Here we provide, at least to our knowledge, the first evidence that aripiprazole (APPZ) in the water blunts the stress response of exposed fish in a concentration ten times lower than the concentration detected in the environment. Although the mechanism of APPZ in the neuroendocrine axis is not yet determined, our results highlight that the presence of APPZ residues in the environment may interfere with the stress responses in fish. Since an adequate stress response is crucial to restore fish homeostasis after stressors, fish with impaired stress response may have trouble to cope with natural and/or imposed stressors with consequences to their welfare and survival.
References: CNS Drugs. 2006;20(5):389-409. (PMID: 16696579)
PLoS Biol. 2004 May;2(5):E148. (PMID: 15138510)
Expert Opin Pharmacother. 2016;17(7):937-52. (PMID: 26891879)
Fish Physiol Biochem. 2008 Mar;34(1):95-101. (PMID: 18649027)
PLoS One. 2013 Oct 07;8(10):e75780. (PMID: 24116073)
Chemosphere. 2013 Mar;90(10):2520-5. (PMID: 23228908)
Am J Psychiatry. 2007 Sep;164(9):1411-7. (PMID: 17728427)
Schizophr Res. 2016 Jul;174(1-3):99-105. (PMID: 27112637)
Sci Total Environ. 2015 May 1;514:273-80. (PMID: 25666287)
Curr Pharm Des. 2010;16(5):488-501. (PMID: 19909227)
J Psychopharmacol. 2006 Jul;20(4):536-46. (PMID: 16401666)
N Engl J Med. 2005 Sep 22;353(12):1209-23. (PMID: 16172203)
Neuropharmacology. 1992 Jul;31(7):671-8. (PMID: 1328919)
Environ Toxicol Pharmacol. 2015 Nov;40(3):704-7. (PMID: 26414864)
PLoS One. 2014 Jul 23;9(7):e103232. (PMID: 25054216)
Schizophr Res. 2003 Jun 1;61(2-3):123-36. (PMID: 12729864)
Nat Rev Drug Discov. 2003 Jun;2(6):427-8. (PMID: 12790153)
J Med Invest. 2005 Nov;52 Suppl:284-90. (PMID: 16366516)
J Appl Toxicol. 2013 Jun;33(6):466-70. (PMID: 22120642)
Am J Psychiatry. 2003 Sep;160(9):1651-8. (PMID: 12944341)
Environ Toxicol Pharmacol. 2016 Jan;41:89-94. (PMID: 26667671)
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Jan 10;36(1):60-70. (PMID: 21871520)
Chemosphere. 2009 Nov;77(10):1257-74. (PMID: 19815251)
J Affect Disord. 2014 Jun;162:20-5. (PMID: 24766999)
Iran J Basic Med Sci. 2015 Sep;18(9):938-41. (PMID: 26523226)
Psychopharmacology (Berl). 2016 Apr;233(7):1311-22. (PMID: 26856855)
J Clin Psychiatry. 2015 Apr;76(4):e487-98. (PMID: 25919841)
Curr Drug Targets CNS Neurol Disord. 2002 Apr;1(2):141-7. (PMID: 12769623)
Environ Sci Technol. 2013;47(23):13321-9. (PMID: 24164172)
Schizophr Res. 2009 Jan;107(1):1-12. (PMID: 19027269)
Behav Brain Res. 2016 Jan 1;296:301-310. (PMID: 26403161)
J Pharmacol Exp Ther. 2002 Jul;302(1):381-9. (PMID: 12065741)
PLoS One. 2015 Oct 16;10(10):e0140800. (PMID: 26473477)
المشرفين على المادة: 0 (Water Pollutants, Chemical)
82VFR53I78 (Aripiprazole)
WI4X0X7BPJ (Hydrocortisone)
تواريخ الأحداث: Date Created: 20161123 Date Completed: 20180521 Latest Revision: 20240326
رمز التحديث: 20240326
مُعرف محوري في PubMed: PMC5118712
DOI: 10.1038/srep37612
PMID: 27874070
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/srep37612