دورية أكاديمية
Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish.
| العنوان: | Developmental bisphenol A exposure impairs sperm function and reproduction in zebrafish. |
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| المؤلفون: | Chen J; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Saili KS; Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97333, USA., Liu Y; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Li L; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Zhao Y; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Jia Y; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Bai C; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Tanguay RL; Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center, Oregon State University, Corvallis, OR 97333, USA., Dong Q; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China., Huang C; Institute of Environmental Safety and Human Health, Wenzhou Medical University, Wenzhou 325035, China. Electronic address: cjhuang5711@163.com. |
| المصدر: | Chemosphere [Chemosphere] 2017 Feb; Vol. 169, pp. 262-270. Date of Electronic Publication: 2016 Nov 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Benzhydryl Compounds/*toxicity , Fertilization/*physiology , Free Radical Scavengers/*toxicity , Phenols/*toxicity , Reproduction/*physiology , Spermatozoa/*physiology , Water Pollutants, Chemical/*toxicity , Zebrafish/*growth & development, Animals ; Dose-Response Relationship, Drug ; Fertilization/drug effects ; Male ; Reproduction/drug effects ; Spermatozoa/drug effects |
| مستخلص: | The developmental and reproductive toxicity of bisphenol A (BPA) has been demonstrated in a variety of model systems. Zebrafish (Danio rerio) were waterborne-exposed to BPA during three different developmental stages: embryonic period:6 h post fertilization (hpf) to 5 months post fertilization (mpf); larval period: 6 days post fertilization (dpf) to 5 mpf; and sexually mature period: 3 mpf to 5 mpf. Evaluations included F0 adult growth, reproduction parameters, and F1 offspring development. BPA exposure did not affect zebrafish growth in any of exposure groups. Testis weight was decreased only following the 6 hpf to 5 mpf 0.001 μM BPA exposure. The lowest effect level indicated by a reduction in sperm volume, density, motility, and velocity across a range of exposure durations was 0.001 μM, with all but sperm density significant for the longest exposure duration, which was also the only significant endpoint for the lowest exposure concentration in the 3-5 mpf exposure group. Nonmonotonic concentration-response curves were noted for all F0 reproductive endpoints for at least one of the two longest exposure durations. For the F1 offspring of fish exposed from 6 hpf to 5 mpf, malformations and mortality were increased following 0.001 μM BPA exposure, while egg production and fertilization were reduced in higher concentration treatment groups. Overall, BPA exposure during three different developmental periods impaired zebrafish reproductive development, with most significance changes found in the lowest concentration treatment groups. Genetic impacts on gamete development may underlie the secondary effects of reduced fertilization rate, embryonic mortality, and malformations. (Copyright © 2016 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bisphenol A; Chronic exposure; Procreation ability; Reproduction; Sperm motility; Zebrafish |
| المشرفين على المادة: | 0 (Benzhydryl Compounds) 0 (Free Radical Scavengers) 0 (Phenols) 0 (Water Pollutants, Chemical) MLT3645I99 (bisphenol A) |
| تواريخ الأحداث: | Date Created: 20161124 Date Completed: 20170124 Latest Revision: 20181202 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.chemosphere.2016.11.089 |
| PMID: | 27880925 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2016.11.089 |