دورية أكاديمية
Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity.
| العنوان: | Galloylquinic acid derivatives from Copaifera langsdorffii leaves display gastroprotective activity. |
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| المؤلفون: | Motta EV; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil., Lemos M; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil., Costa JC; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil., Banderó-Filho VC; School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland., Sasse A; School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland., Sheridan H; School of Pharmacy and Pharmaceutical Sciences and Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin 2, Ireland., Bastos JK; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903, Ribeirão Preto, SP, Brazil. Electronic address: jkbastos@fcfrp.usp.br. |
| المصدر: | Chemico-biological interactions [Chem Biol Interact] 2017 Jan 05; Vol. 261, pp. 145-155. Date of Electronic Publication: 2016 Nov 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Fabaceae/*chemistry , Gastric Mucosa/*drug effects , Plant Leaves/*chemistry , Protective Agents/*pharmacology , Quinic Acid/*pharmacology, 2-Pyridinylmethylsulfinylbenzimidazoles/pharmacology ; Administration, Oral ; Animals ; Carbon-13 Magnetic Resonance Spectroscopy ; Cell Death/drug effects ; Chemical Fractionation ; Chromatography, High Pressure Liquid ; Flow Cytometry ; Gallic Acid/administration & dosage ; Gallic Acid/pharmacology ; Inhibitory Concentration 50 ; Male ; Mice, Inbred BALB C ; Pantoprazole ; Protective Agents/administration & dosage ; Proton Magnetic Resonance Spectroscopy ; Quinic Acid/administration & dosage ; Quinic Acid/chemistry ; Quinic Acid/isolation & purification |
| مستخلص: | Nine new methylated galloylquinic acids were isolated from an aqueous fraction of Copaifera langsdorffii (Fabaceae-Caesalpinioideae) leaf hydroalcoholic extract (3-8, 11, 12, and 14), along with three known methylated galloylquinic acids (1, 2, and 15) and four galloylquinic acids (9, 10, 13, and 16). These compounds were characterized by nuclear magnetic resonance spectroscopy and mass spectrometry. They were further tested in a gastroprotection assay (Ethanol-HCl induced ulcer model in mice), in which all of them significantly reduced the total lesion area, and increased the cure ratio in comparison with pantoprazole. Also, the tested compounds displayed cytotoxicity against gastric adenocarcinoma cells. (Copyright © 2016. Published by Elsevier Ireland Ltd.) |
| فهرسة مساهمة: | Keywords: Adenocarcinoma; Copaiba; Galloylquinic acid; Gastroprotection; Phenol; Ulcer |
| المشرفين على المادة: | 0 (2-Pyridinylmethylsulfinylbenzimidazoles) 0 (Protective Agents) 058C04BGYI (Quinic Acid) 632XD903SP (Gallic Acid) D8TST4O562 (Pantoprazole) |
| تواريخ الأحداث: | Date Created: 20161130 Date Completed: 20170207 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cbi.2016.11.028 |
| PMID: | 27894855 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7786 |
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| DOI: | 10.1016/j.cbi.2016.11.028 |